N-sulfenylated pyrazolines, compositions and use

ABSTRACT

N-sulfenylated and N-acrylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their environment. The pyrazolines are selected from those of Formulae I to III wherein R 1 , R 2 , R 3 , Q, A, B, J, K, Y, m, n and p are as defined in the test: ##STR1##

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation-in-part via the PCT of U.S. Ser. No.07/249,881 filed Sept. 27, 1988 and U.S. Ser. No. 07/304,011, filed Jan.25, 1989 both now abandoned.

BACKGROUND OF THE INVENTION

The following publications disclose pyrazolines:

    ______________________________________                                        U.S. Pat. No. 4,070,365                                                                             EPA 21,506                                              U.S. Pat. No. 4,156,007                                                                             EPA 58,424                                              U.S. Pat. No. 4,174,393                                                                             EPA 65,334                                              U.S. Pat. No. 4,663,341                                                                             EPA 113,213                                             WO 88/05046           EPA 153,127                                             WO 88/07994           EPA 286,346                                             WO 89/00562           EPA 300,692                                             ______________________________________                                         Grosscurt et al., J. Agric Food Chem., Vol. 27, No. 2 (1979).            

SUMMARY OF THE INVENTION

This invention pertains to compounds of Formulae I, II and III,including all geometric and stereoisomers, agriculturally suitable saltsthereof, compositions containing them and their use as arthropodicidesin agricultural and home uses. Hereafter, the compounds, isomers andsalts are referred to as compound(s) for the sake of simplicity. Thecompounds are: ##STR2## wherein

A is a 1, 2 or 3-atom bridge comprising 0 to 3 carbon atoms, 0 to 1oxygen atoms, NR₆, or S(O)q, wherein each carbon individually can besubstituted with 1 to 2 substituents selected from 1 to 2 halogen, C₁ toC₆ alkyl, C₂ to C₄ alkoxycarbonyl or phenyl optionally substituted with1 to 3 substituents independently selected from W and one of the carbonatoms can be combined into the group C(O) or C(S);

B is H, C₁ to C₆ alkyl, C₄ to C₇ cycloalkyl alkyl, C₃ to C₆ cycloalkyloptionally substituted with 1 to 2 halogens or 1 to 2 CH₃ ; C₁ to C₆haloalkyl, C₂ to C₆ alkenyl, C₂ to C₆ haloalkenyl, C₂ to C₆ alkynyl,OR₇, C₂ to C₆ alkoxyalkyl, C₂ to C₆ cyanoalkyl, C₃ to C₈alkoxycarbonylalkyl, CO₂ R₄, C(O)R₄, C(O)NR₄ R₅, C(S)NR₄ R₅, C(S)R₄,C(S)SR₄, phenyl, phenyl substituted by (R₁₄)p, benzyl, or benzylsubstituted with 1 to 3 substituents independently selected from W;

J is H, C₁ to C₄ alkyl or phenyl optionally substituted with W;

K is H or CH₃ ;

q is 0, 1 or 2;

R₁, R₂, R₃ and R₁₄ are independently selected from R₄, halogen, CN, N₃,SCN, NO₂, OR₄, SR₄, S(O)R₄, S(O)₂ R₄, OC(O)R₄, OS(O)₂ R₄, CO₂ R₄,C(O)R₄, C(O)NR₄ R₅, S(O)₂ NR₄ R₅, NR₄ R₅, NR₅ C(O)R₄, OC(O)NHR₄, NR₅C(O)NHR₄ and NR₅ S(O)₂ R₄ ; or when m, n or p is 2, R₁, R₂, R₃ or R₁₄can independently be taken together as OCH₂ O, OCH₂ CH₂ O or CH₂ CH₂ O,to form a 5 or 6-membered ring, each of which can be independentlysubstituted with 1 to 4 halogen atoms or 1 to 2 methyl groups;

R₄ is selected from H, C₁ to C₆ alkyl, C₃ to C₆ cycloalkyl, C₃ to C₈alkoxycarbonylalkyl, C₃ to C₆ alkenyl, C₃ to C₆ alkynyl, C₁ to C₆haloalkyl, C₃ to C₆ haloalkenyl, C₁ to C₆ alkyl substituted with CN, CO₂CH₃, CO₂ CH₂ CH₃, OCH₃, OCH₂ CH₃, SCH₃, SCH₂ CH₃ or NO₂, or R₄ is phenylor benzyl, either optionally substituted with W; or R₄ and R₅ can betaken together as (CH₂)₄, (CH₂)₅ or CH₂ CH₂ OCH₂ CH₂ ;

R₅ is selected from H, C₁ to C₄ alkyl, C₃ to C₄ alkenyl, C₃ to C₄alkynyl or C₁ to C₄ haloalkyl;

m, n and p are independently 1 to 3;

W is halogen, CN, NO₂, C₁ to C₂ alkyl, C₁ to C₂ haloalkyl, C₁ to C₂alkoxy, C₁ to C₂ haloalkoxy, C₁ to C₂ alkylthio, C₁ to C₂ haloalkylthio,C₁ to C₂ alkylsulfonyl or C₁ to C₂ haloalkylsulfonyl;

R₆ is H, C₁ to C₄ alkyl, C₁ to C₄ haloalkyl, C₂ to C₄ alkenyl, C₂ to C₄haloalkenyl, phenyl optionally substituted with W or benzyl optionallysubstituted with W;

R₇ is H, C₁ to C₄ alkyl, C₂ to C₄ alkenyl, C₂ to C₄ alkynyl, C₂ to C₄alkylcarbonyl, C₂ to C₄ alkoxycarbonyl or C₁ -C₄ alkylsulfonyl;

Q is SX, C₂ to C₂₂ alkoxycarbonyl, C₂ to C₂₂ haloalkoxycarbonyl, C₇ toC₁₅ phenoxycarbonyl optionally substituted with 1 to 3 substituentsselected from W; C₇ to C₁₅ phenyl carbonyl optionally substituted with 1to 3 substituents independently selected from W; C₂ to C₂₂ alkylcarbonyl, C₂ to C₂₂ haloalkyl carbonyl, CHO, C(O)CO₂ R₅, or C₈ to C₁₂benzyloxycarbonyl optionally substituted with 1 to 3 substituentsindependently selected from W; when Q is other than SX, R₃ is other thanCO₂ R₄, C(O)R₄, SO₂ NR₄ R₅ or CONR₄ R₅ ;

Y is C₅ to C₂₂ alkyl, C₂ to C₂₂ haloalkyl, C₅ to C₂₂ alkoxyalkyl, C₄ toC₂₂ alkoxyalkoxyalkyl, C₅ to C₁₂ alkylthio, C₅ to C₁₂ haloalkylthio, C₅to C₂₂ alkylcarbonyl, C₅ to C₂₂ haloalkylcarbonyl, C₅ to C₂₂alkoxycarbonyl, C₃ to C₂₂ haloalkoxycarbonyl, or SX;

Z is C₇ to C₂₂ alkyl, C₂ to C₂₂ haloalkyl, C₇ to C₂₂ alkoxyalkyl, C₄ toC₂₂ alkoxyalkoxyalkyl, C₇ to C₁₂ alkylthio, C₇ to C₁₂ haloalkylthio, C₇to C₂₂ alkylcarbonyl, C₇ to C₂₂ haloalkylcarbonyl, C₇ to C₂₂alkoxycarbonyl, C₃ to C₂₂ haloalkyoxycarbonyl, C₇ to C₁₅ phenylcarbonyloptionally substituted by 1 to 3 substituents independently selectedfrom W; or SX; ##STR3##

R₈ and R₁₂ are independently C₁ to C₆ alkyl, C₁ to C₆ haloalkyl, C₃ toC₆ cycloalkyl, C₄ to C₇ cycloalkylalkyl, phenyl optionally substitutedby 1 to 2 substituents selected from W, benzyl optionally substituted by1 to 2 substituents independently selected from W, phenethyl optionallysubstituted by 1 to 2 substituents independently selected from W, C₂ toC₆ cyanoalky, C₂ to C₆ alkoxyalkyl, C₃ to C₈ alkoxycarbonylalkyl, C₄ toC₈ dialkylaminocarbonylalkyl; or R₈ and R₁₂ can be taken together as(CH₂)₄, (CH₂)₅ or (CH₂)₂ O(CH₂)₂,

R₉ is F, C₁ to C₂₂ alkyl, C₃ to C₆ cycloalkyl, C₃ to C₆ cycloalkoxy, C₂to C₈ dialkylamino, C₁ to C₆ haloalkyl, phenyl or phenoxy eitheroptionally substituted by 1 to 2 substituents independently selectedfrom W; C₁ to C₂₂ alkoxy, C₁ to C₄ alkoxy substituted by cyano, nitro,C₂ to C₄ alkoxy, C₄ to C₈ alkoxyalkoxy, C₁ to C₂ alkylthio, C₂ to C₃alkoxycarbonyl, C₃ to C₅ dialkylaminocarbonyl, phenyl or 1 to 6halogens; or R₉ is morpholino, piperidino or pyrrolidino, 1-naphthoxy,2,2-dimethyl-2,3-dihydrobenzofuranoxy-7 or ON=C(CH₃)SCH₃ ;

R₁₀ and R₁₁ are independently C₁ to C₄ alkyl, C₂ to C₄ haloalkyl orphenyl optionally substituted by 1 to 2 substituents independentlyselected from W; or R₁₀ and R₁₁ can be taken together as (CH₂)₂, (CH₂)₃or CH₂ C(CH₃)₂ CH₂ ;

Y' is S or O; and

a is 0 to 2.

Preferred compounds A are those of Formula I, II or III wherein:

R₁, R₂, R₃ and R₁₄ are independently R₄, CO₂ R₄, halogen, CN, NO₂, OR₄,SR₄, S(O)R₄, S(O)₂ R₄ or NR₄ R₅, or when m, n or p is 2;

R₁, R₂, R₃ or R₁₄ can be taken together as OCH₂ O, OCH₂ CH₂ O or CH₂ CH₂O, each of which can be substituted with 1 to 4 halogen atoms or 1 to 2methyl groups;

R₄ is C₁ to C₂ alkyl, C₃ to C₄ alkenyl, C₁ to C₂ haloalkyl, C₃ to C₄haloalkenyl or phenyl optionally substituted with halogen;

R₅ is H or C₁ to C₂ alkyl;

Q is SX, CHO, C₂ to C₆ alkoxycarbonyl, C₂ to C₆ haloalkoxycarbonyl, C₂to C₆ alkylcarbonyl, C₂ to C₄ haloalkylcarbonyl, C₇ to C₁₀phenoxycarbonyl, C₇ to C₁₀ phenylcarbonyl or C₈ to C₁₀ benzyloxycarbonyleach phenoxy, phenyl or benzyloxy group optionally substitutfed with 1to 2 substituents selected from W;

X is X₁, X₂, X₃, X₄ or X₅ ;

R₈ and R₁₂ are independently C₁ to C₆ alkyl, C₁ to C₆ haloalkyl, C₅ toC₆ cycloalkyl, C₃ to C₈ alkoxycarbonylalkyl, phenyl, benzyl orphenethyl, each optionally independently substituted with W; or R₈ andR₁₂ can be taken together as (CH₂)₄, (CH₂)₅ or (CH₂)₂ O(CH₂)₂ ;

R₁₀ and R₁₁ are independently C₁ to C₃ alkyl or phenyl;

a is 2;

Formula III is ##STR4##

X'is O or S;

t is 0, 1 or 2;

V is O, S(O)_(q), or NR₆ ;

Z' is O or NR₆ ;

R₁₃ is H, halogen, C₁ to C₆ alkyl, C₂ to C₄ alkoxycarbonyl, phenyl orphenyl substituted by 1 to 3 substituents independently selected from W;and

g is 0, 1 or 2.

Preferred compounds B are compounds A wherein:

R₁ is halogen, CN, NO₂, OCF₂ H, OCF₃, OCH₂ CF₃, OCF₂ CF₂ H, CF₃ or whenm is 2 then R₁ may be taken together as CH₂ C(CH₃)₂ O or CF₂ CF₂ O toform a 5 membered ring;

R₂ is H, halogen, CN, NO₂, OCH₃, OCF₂ H, OCH₂ CF₃, OCF₃, SCH₃, SCF₂ H,SCF₃ CF₃, OCF₂ CF₂ H or phenoxy;

R₃ and R₁₄ are independently R₂ of CO₂ R₄ ;

Q is SX, C₂ to C₄ alkoxycarbonyl, C₂ to C₄ alkylcarbonyl, C₇ to C₈phenylcarbonyl or CHO;

X is X₁, X₂ or X₃ ;

R₈ is C₁ to C₄ alkyl, CF₃, cyclohexyl, phenyl optionally substitutedwith W or benzyl optionally substituted by W;

R₉ is F, C₁ to C₂₂ alkyl, C₁ to C₆ haloalkyl, phenyl or phenoxyoptionally substituted by W; C₁ to C₂₂ alkoxy, dimethylamino or C₁ to C₄alkoxy substituted with NO₂, C₂ to C₄ alkoxy or 1 to 6 halogens;

m, n or p are independently 1 to 2 and one substituent is in the4-position and

B is H, C₁ -C₄ alkyl, CO₂ R₄, C(O)R₄ or phenyl optionally substituted by(R₁₄)p.

Preferred compounds C are preferred compounds B wherein:

X is X₁ ;

R₈ is C₁ to C₄ alkyl; R₉ is C₁ to C₂₂ alkoxy;

Formula III is III-1 or III-2;

V is O or CH₂ ;

t is 1; and

R₁₃ is H.

Preferred compounds D are preferred compounds B wherein:

X is X₂ ;

R₈ is C₁ to C₄ alkyl or phenyl optionally substituted with CH₃ or Cl;and

R₉ is C₁ to C₆ alkyl, C₁ to C₆ haloalkyl, dimethylamino or phenyloptionally substituted with CH₃ or Cl.

Preferred compounds E are preferred compounds C of Formula I.

Preferred compounds F are preferred compounds B of Formula II.

Preferred compounds G are preferred compounds B of Formula III.

Specifically preferred are the compounds:

H. methyl 3,4-di(4-chlorophenyl)-1-[[N-[[(ethoxycarbonyl)(1-methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazoleof preferred E;

I. N-acetyl-3,4-bis(4-chlorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-1-carboxamide of preferred F; and

J. methyl7-chloro-3,3a,4,5-tetrahydro-2-[[N-[[N-methyl-N-[octadecyloxy)carbonyl]amino]thio]-N-[4-(trifluoromethyl)-phenyl]amino]carbonyl]-2H-benz[g]indazole-3a-carboxylateof preferred G.

DETAILED OF THE INVENTION

Compounds of Formulae I, II and III can be prepared by the reaction of apyrazoline compound of Formula V, VI or VII with a sulfenyl halide ofFormula IV. ##STR5## wherein

Y in Formula IV represents a halogen such as chloro, bromo, or iodo.

The treatment of V, VI or VII with IV is carried out by mixing the tworeagents in the presence of a base and a solvent. Suitable bases are thetertiary amines such as triethylamine or pyridine. Alkali metal basessuch as sodium hydride or potassium tert-butoxide or organo lithiumbases such as aryl or alkyllithium also can be utilized.

Suitable solvents include methylene chloride, tetrahydrofuran or ether.In some cases, the base can also be used as the solvent, e.g., pyridine.In most cases, it is desirable to mix compounds of Formula V, VI or VIIand the desired base at a low temperature of about 5° C. to -70° C.which is held at this temperature during treatment with the appropriateamount of compounds of Formula IV. The mixture is then warmed to roomtemperature to complete the reaction. Generally, it is desirable toemploy a moderate stoichiometric excess, up to 10% of the base andcompounds of Formula IV relative to compounds of Formula V, VI or VII.Water should be excluded from the reaction mixture by using anhydrousreagents and conducting the treatment in a nitrogen atmosphere. Theproduct is isolated and purified by conventional techniques asdemonstrated in Example 1. The pyrazoline precursors of Formula V, VI,and VII are compounds that can be prepared by methods known to thoseskilled in the art. The methods of pyrazoline synthesis have beenrecently reviewed by El-Rayyes and Al-Awadi in "Synthesis" page 1028 to1042, November 1985.

Compounds of Formula V where B=H can be prepared by the followingsequence of reactions as shown in Scheme 1. ##STR6##

In another embodiment, certain compounds of Formula V wherein B is otherthan H can be prepared directly from compounds of Formula V wherein B isH by further treatment with a base and the appropriate type ofelectrophile as illustrated by Scheme 2. ##STR7##

Compounds of Formula V where B is also phenyl or substituted phenyl canbe prepared by reaction of a substituted ketone of Formula X withhydrazine as shown in Scheme 3. ##STR8##

For compounds of Formula VI, Grosscurt et al., have published thesynthesis of 3,4-diphenyl-1-phenylcarbamoyl-2-pyrazoles in Journal ofAgricultural and Food Chemistry, 27:406-409 (1979). Similar methods ofsynthesis are also presented in U.S. Pat. No. 4,633,341. Compounds ofFormula VII have been prepared using procedures indicated in PCT WO88/05046.

Sulfenyl halides of the type XSY (Formula IV) wherein X and Y are asspecified in this disclosure are known in the literature. A reviewarticle by Kule in Synthesis, 561, (1970) describes the chemistry andpreparation of the majority of sulfenyl halides utilized in thisinvention. The synthesis of N-chlorosulfenylcarbamates was described inU.S. Pat. No. 3,843,689. Other sulfenyl halides can be prepared by thegeneral procedures described in these literature examples or obviousmodifications thereof.

Compounds of Formula I (Q is other than SX) are synthesized fromcompounds of Formula VI. Reaction of compounds of Formula VI in thepresence of an acid acceptor with electrophilic carbonyl-containingreagents results in substitution on nitrogen. Strong bases known todeprotonate ureas such as potassium t-butoxide, potassium hydride andsodium hydride are the preferred acid acceptors in the process. Suitableelectrophiles include, but are not restricted to, acyl halides, acidanhydrides, carbonates, and chloroformates. The reaction sequence isnormally run in the temperature range of -10° to 25° C., but can be runat temperatures as high as 110° C. or as low as -50° C. in certaincases. Solvents which are not deprotonated under the conditions of thereaction such as tetrahydrofuran, dimethylformamide, dimethoxyethane,and diethyl ether are preferred. The electrophiles used in this processare well known to those skilled in the art and are generallycommercially available. ##STR9## wherein:

QX is selected from acyl halides, chloroformates and acid anhydrides.

The following Examples illustrate the invention.

EXAMPLE 13,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[(4-(trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)aminosulfenyl]-2H-benz[g]indazole-2-carboxamide

Step A:3,3a,4,5-Tetrahydro-N-[4-(trifluoromethyl)phenyl]-2H-benz[g]indazole-2-carboxamide

Step A:3,3a,4,5-Tetrahydro-N-[4-(trifluoromethyl)phenyl]-2H-benz[g]indazole-2-carboxamide

A mixture of 10.0 g of α-tetralone, 2.0 g of paraformaldehyde, 6.5 g ofdimethylamine hydrochloride and 1.75 ml of conc. HCl in 20 ml of ethanolwas heated at reflux for 24 h, cooled to room temperature and thenpartitioned between ether and water. The aqueous extracts were madebasic with 1N aqueous NaOH and extracted with ether. The ether extractswere dried over magnesium sulfate and concentrated to 12.3 g of a yellowoil. The residual oil was dissolved in 40 ml of n-propyl alcohol,combined with 6.7 ml of hydrazine hydrate and heated at reflux for 1 h.The reaction mixture was then concentrated under vacuum, partitionedbetween 5% aqueous NaHCO₃ and methylene chloride and dried overmagnesium sulfate. To the methylene chloride extracts were added 12.5 gof 4-trifluoromethylphenyl isocyanate and the mixture was then refluxedone hour, cooled to room temperature and concentrated to 26.1 g of abrown oil. Chromatography on silica gel followed by trituration withether afforded 11.78 g of the title compound as a tan powder, m.p.149°-151° C.

¹ H NMR (CDCl₃), δ1.9 (m,1H), 2.4 (m, 1H), 3.0 (m, 2H), 3.5 (m,2H), 4.4(m,1H), 7.3 (m,3H), 7.58 (d,2H), 7.65 (d,2H), 8.0 (d,2H), 8.3 (bs,1H).

Step B:3,3a,4,5-tetrahydro-3a-methoxycarbonyl-N-[4'-(trifluoromethyl)phenyl]-2H-benz[g]indazole-2-carboxamide

To a solution of 0.9 ml of diisopropylamine in 10 ml of THF, at -78° C.,was added 2.3 ml of 2.5M n-butyl lithium in hexane and the mixture wasstirred for 5 mins. To this solution was added a solution of 1.0 g ofthe title compound of Step A in 5 ml of THF. The reaction was warmed to0° C., recooled to -78° C. and then 0.75 ml of methyl chloroformate wasadded. The reaction mixture was then stirred for 24 h, with gradualwarming to room temperature, quenched with 0.5 ml of glacial aceticacid, and poured into a 5% solution of aqueous NaHCO₃. The mixture wasextracted with chloroform, dried over magnesium sulfate andconcentrated. Chromatography on silica gel with 30% ethyl acetate hexaneafforded 0.25 g of the title compound, m.p. 177° to 180° C.

¹ H NMR (CDCl₃), δ2.1 (m,1H), 2.7 (m,1H), 3.0 (m,2H), 3.71 (s,3H), 3.76(d, 1H), 4.58 (d,1H), 7.3 (m,3H), 7.57 (d,2H), 7.66 (d,2H), 8.0 (d,1H),8.22 (s,1H).

Step C: Ethyl (1-methylethyl)carbamate

To a solution of ethyl chloroformate (21.7 g, 0.2 mol) in 200 ml ethercooled to 0° C. was added dropwise 35.7 ml of isopropylamine withstirring and cooling. After complete addition of the amine, the reactionmixture was stirred at room temperature for an additional 0.5 hour. Thereaction mixture was filtered, and the ether solution was washed withwater, and dried over magnesium sulfate. Evaporation of the ether anddistillation of the residue in a Kugelrohr apparatus resulted in 22.6 gof the title compound B.p.: 50°-66° C. (bath temperature) at 1.5 mm Hg.

Step D: Ethyl (chlorosulfenyl)(1-methylethyl)carbamate

To a solution of ethyl (1-methylethyl)carbamate (13.1 g, 0.1 mol) in 100ml methylene chloride cooled to 0° C. was added sulfur dichloride (11.3g, 0.11 mol) in one portion. While maintaining the temperature of themixture at 0° C., pyridine (8.7 g, 0.11 mol) was added dropwise overeleven minutes. After complete addition of the pyridine the temperaturewas allowed to rise to room temperature and stirring was continued foradditional 1.5 hours. The mixture was let stand overnight. Methylenechloride was evaporated under vacuum and 100 ml hexane was added.Filteration of the pyridine hydrochloride and evaporation of hexaneresulted in an orange oil which was distilled in a Kugelrohr apparatusto give 12.5 g of the title compound Bp: 64°-80° (bath temperature) at1.4 mm Hg.

Step E:3.3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)aminosulfenyl]-2H-benz[g]indazole-2-carboxamide

To a solution of the title compound of Step B (2.0 g, 4.8 mmol) in 50 mlmethylene chloride cooled to 0° C. was added triethylamine (1.0 g, 0.01mol) and ethyl (chlorosulfenyl)(1-methylethyl)carbamate from Step D (1.4g, 7.7 mmol). The mixture was allowed to warm to room temperature andstirred for one hour. The crude mixture was purified by silica columnchromatography using ether-hexane (1:2) as eluent. The title compound(2.38 g) was obtained in about 90% purity (mp: 130°-134°). Extraction ofthe product with ether-hexane (2:1) gave 1.8 g of a highly pure materialmp: 139°-140° C.

¹ H NMR (CDCl₃); δ0.92 (t,3H), 1.26 (d,3H), 1.35 (d,3H), 1.95 (m,1H),2.7 (m,1H), 2.95 (m,2H), 3.67 (s,3H), 3.8 (m,3H), 4.5 (m,2H), 7.2(m,3H), 7.45 (d,3H), 7.65 (d,2H).

EXAMPLE 23,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-(1-methylpropoxylcarbonylsulfenyl)-2H-benz[g]indazole-2-carboxamide

Step A: (1-methylpropoxycarbonyl)sulfenyl chloride

Chlorocarboxylsulfenyl chloride (13.1 g, 0.1 mol) was mixed with2-butanol (6.7 g, 0.09 mol) and warmed to about 35° to 40° C. for onehour. Distillation resulted in the title compound (5.93 g) Bp. 70°C./0.8 mmHg. NMR spectrum was consistent with the structure.

Step B:3,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-(1-methylpropoxycarbonylsulfenyl)-2H-benz[g]indazole-2-carboxamide.

To a solution of the title compound of Step B (Example 1) (0.4 g, 0.96mmol) in 5 ml methylene chloride was added triethylamine (0.12 g) andcooled to 0° C. To this solution was added(1-methylpropoxycarbonyl)sulfenyl chloride (Step A) (0.2 g, 0.0012 mol).The mixture was stirred at room temperature for one hour. At this sagethin layer chromatography indicated only partial conversion, therefor,addition- al amounts of (1-methylpropoxycarbonyl)sulfenyl chloride (0.2g) and triethylamine (0.12 g) was added and the mixture was let standovernight. The reaction mixture was subjected to silica gel columnchromatography using hexane-ether (7:1) as eluent. The title compoundwas obtained (0.22 g) in high purity; m.p.: 125°-126° C.

¹ H NMR (CDCl₃): δ0.9 (m,3H), 1.3 (m,3H), 1.6 (m,2H), 1.9 (m,1H), 2.8(m,3H), 3.67 (s,3H), 3.8 (d,1H), 4.5 (d,1H), 5.0 (m,1H), 7.05 (m,3H),7.25 (m,1H), 7.5 (d,2H), 7.57 (d,2H).

EXAMPLE 33,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-(dibutylaminosulfenyl)-2H-benz[g]indazole-2-carboxamide

Step A: N,N'-bis-(dibutylamino)disulfide

To a solution of dibutylamine (52 g, 0.4 mol) in 200 ml hexane cooled to0° C. was added sulfur monochloride (13.5 g, 0.1 mol (dropwise withstirring over a period of 20 minutes. The reaction mixture was warmed upto room temperature and stirring was continued for 30 minutes. Thereaction mixture was filtered and hexane was evaporated to yield 30.1 gof the title compound.

Step B: Dibutylaminosulfenylchloride

To a solution of N,N'-bis-(dibutylamino)disulfide (13.2 g, 0.05 mol) in12 ml carbontetrachloride was added. Sulfuryl chloride (6.75 g, 0.05mol) was added dropwise at ambient temperature. Then heated to about 60°C. for 10 minutes, and distilled to give the title compound (7.55 g) asa yellow liquid. Bp: 80°-87° C. at 0.6 mm Hg.

Step C:3,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-(dibutylaminosulfenyl)-2H-benz[g]indazole-2-carboxamide.

To a solution of the title compound of Step B (Example 1) (0.4 g, 0.96mmol) in 8 ml methylene chloride cooled to 0° C. was added triethylamine(0.15 g) and dibutylaminosulfenylchloride (0.2 g). The reaction mixturewas warmed to room temperature and stirred for one hour. The mixture wassubjected to silica gel column chromatography using hexane-ether (6:1)as the eluent. The title compound was obtained (0.24 g) in high purity.

¹ H NMR (CDCl₃): δ0.7 to 1.7 (m,14H), 1.9 (m,1H), 2.6 to 3.1 (m, 7H),3.67 (s,3H), 3.75 (d,1H), 4.45 (d,1H), 7.1 (m,3H), 7.25 (m,1H), 7.4(,2H), 7.6 (d,2H).

EXAMPLE 47-Chloro-3,3a,4,5-tetrahydro-3a-methxoycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-[N'-(methyl)-N'-(hexoxycarbonyl)aminosulfenyl]-2H-benz[glindazole-2-carboxamide

Step A: ((2-(3-chlorophenyl)ethyl)methanesulfonate

To a 0° C. solution of 30.0 g of 3-chlorophenethyl alcohol and 15. 3mlof methane sulfonyl chloride in 150 ml of THF was added, dropwise, asolution of 28.0 ml of triethylamine in 50 ml of THF. The reaction waswarmed to room temperature, stirred overnight, and then filtered. Thefiltrate was partitioned between aqueous sodium bicarbonate and ether.The organic extracts were then dried over magnesium sulfate, filteredand concentrated under reduced pressure to afford 45.93 g of a clear,colorless oil.

Step B: 3-chlorobenzenebutanoic acid

To a mixture of 8.0 g of 60% sodium hydride in 300 ml of THF, under N₂,was added dropwise a solution of 31.0 ml of diethyl malonate in 50 ml ofTHF. Upon complete addition of the diethyl malonate, a pale yellowhomogeneous solution was obtained. To this was added a solution of 45.93g of the sulfonate from Step A and the mixture was then heated at refluxovernight. The reaction was then cooled to room temperature, poured into400 ml of 1N HCl, and extracted with ether. The ether extracts weredried over magnesium sulfate, filtered and concentrated under reducedpressure to afford 68.9 g of a yellow oil. The crude oil was dissolvedin 400 ml of methanol, 100 ml of H₂ O and 40 ml of 50% aqueous NaOH. Thereaction was stirred overnight and the methanol was then removed atreduced pressure. The crude residue was partitioned between H₂ O andether, the aqueous extracts were acidified with concentrated HCl andthen extracted several times with ether. The ether extracts were driedover magne- sium sulfate, filtered and concentrated to afford 51.7 g ofa yellow oil. The crude residue was dissolved in 200 ml of toluene andheated at reflux for 4 days under N₂ to effect decarboxylation. Afterthis time toluene was removed by concentration at reduced pressure toafford 35.72 g of a yellow oil. ¹ H NMR analysis of the crude productwas consistent with 3-chlorobenzene- butenoic acid of purity estimatedto be 80%. The crude product was used without further purificationdirectly in the next step.

Step C: 6-chloro-3,4-dihydro-1(2H)-naphthalenone

A mixture of 35.72 of the product from Step B and 50 ml of thionylchloride was heated at reflux for 2 hours and then stirred at roomtemperature for 18 hours. After this time thionyl chloride was removedat reduced pressure and the product was dissolved in carbontetrachloride and concentrated at reduced pressure. The residue wasdissolved in 150 ml of dichloroethane cooled to 0° C. and 28 g ofaluminum chloride was added portionwise over about 1 hr in approximately3 g portions. After stirring for 3 hrs the reaction was poured over amixture of ice/1N HCl and extracted three times with methylene chloride.The organic extracts were dried over magnesium sulfate and concentratedto approximately 30 g of a brown oil. Chromatography on silica gel with10% ethyl acetate/hexane afforded 17.83 g of6-chloro-3,4-dihydro-1(2H)-naphthalenone as a brown oil. ¹ H NMR wasconsistent with the structure.

Step D: 7-chloro-3,3a,4-5-tetrahydro-N-[4-(trifluoromethyl)phenyl]-2H-benz[g]-indazole-2-carboxamide

a mixture of 6-chloro-3,4-dihydro-1(2H)-naphthalenone (Step C), 2.5 g ofdimethylamine hydrochloride, 1.0 g of paraformaldehyde, 0.7 ml ofconcentrated HCl and 15 ml of ethanol was combined and heated at refluxfor 18 hrs. The reaction was then concentrated at re- duced pressure andpartitioned between H₂ O and ether. The aqueous extracts were made baicwith 1N NaOH and then extracted three times with ether. The etherextracts were dried over magnesium sulfate and concentrated to 4.64 g ofa yellow oil. This compound was dissolved in 25 ml of ethanol and 1.5 mlof hydrazine hydrate was added followed by 5 to 6 drops of 50% sodiumhydroxide. The reaction was then heated at reflux, under N₂, for 2 to 3hrs after which time it was cooled and most of the ethanol was removedby concentration at reduced pressure. The crude residue was partitionedbetween saturated aqueous sodium bicarbonate and methylene chloride. Themethylene chloride extracts were dried over magnesium sulfate andfiltered. The methylene chloride extracts were then combined with 3.5 gof 4-trifluoromethylphenyl isocyanate and stirred under N₂ overnight.The reaction was then concentrated and the crude residue triturated withether to afford 3.35 g of the title compound as a white powder, m.p.196° to 199° C. ¹ H NMR (CDCl₃) δ1.9 (m,1H), 2.2 (m,1H), 3.0 (m,2H), 3.5(m,2H), 4.43 (m,1H), 7.24 (m,2H), 7.55 (d,2H), 7.67 (d,2H), 7.92 (d,1H),8.20 (s,1H).

Step E:7-chloro-3,3a,4,5-tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-2H-benz[g]indazole-2-carboxamide

A solution of 50 ml of THF and 6.7 ml of diisopropylamine was cooledunder N₂ to -78° C. and then 17.5 ml of 2.5 m n-butyllithium in hexanewas added. After 5 min, a solution of 7.8 g of the title compound ofStep D in 15 ml of THF was added dropwise and the dark red solution thatformed was stirred at -78° C. for an additional 15 min. After this timea solution of 4.6 ml of methyl chloroformate in 10 ml of THF was addeddropwise and the red color dissipated rapidly. The reaction was warmedto room temperature and after 1 hr quenched with 5% aqueous sodiumbicarbonate. The reaction mixture was partitioned between ether and 5%aqueous sodium bicarbonate. The ether extracts were dried over magnesiumsulfate and concentrated to 14. 1 g of a yellow oily solid. The crudeproduct was triturated with ether and the resulting white precipitatewas filtered and dried to afford 5.56 g of the title compound as a whitesolid, m.p. 234° to 236° C.

¹ H NMR (CDCl₃) δ2.1 (m,1H), 2.75 (m,1H), 2.95 (m,2H), 3.71 (s,3H), 3.75(D,1H, J=6 Hz), 4.59 (D,1H, J=6 Hz), 7.25 (m,2H), 7.57 (d,2H), 7.66(d,2H), 7.94 (d,1H), 8.18 (d,1).

Step F:7-chloro-3,3a,4,5-tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-[N'-(methyl)-N'-(hexoxycarbonyl)aminosulfenyl]-2H-benz[g]indazole-2-carboxamide

To a suspension of the title compound of Step E above 2.2 g, 0.005 mol)in 25 ml methylene chloride cooled to 0° C. was added triethylamine (1.0g) and hexyl (chlorosulfenyl) (methyl)carbamate, (prepared in a mannersimilar to Example 1, Step D), (2.5 g 75% pure) dropwise at 0° C. Themixture was stirred at room temperature for additional one hour. Thereaction mixture was concentrated under high vacuum and subjected tosilica gel column chromatography using hexane-ether (1:1) as an eluent.The title compound (2.5 g) was obtained, melting point 128°-129° C. inhigh purity. ¹ H NMR (CDCl₃) δ0.87 (t,3H), 1.18 (m,8H), 1.9(m,1H), 2.8(m,3H), 3.5 (s,3H), 3.66 (s,3H), 3.7 (m,3H), 4.5 (d,1H), 7.05 (m,3H),7.35 (d,2H), 7.6 (d,2H).

Using the procedures described in Examples 1 to 4 with obviousmodifications, the compounds exemplified in Examples 5 to 28 wereprepared.

                                      TABLE A                                     __________________________________________________________________________     ##STR10##                                                                    Example                                                                            R.sub.2                                                                          Z                 m.p. °C.                                                                    .sup.1 H NMR (δ in ppm) in               __________________________________________________________________________                                   CDCl.sub.3                                      5   H  N(CH.sub.3)C(O)OC.sub.4 H.sub.9                                                                 134  1.0(t, 3H), 1.2(m, 4H),                                                       1.9(m, 1H), 2.6-3(m, 3H),                                                     3.5(s, 3H), 3.66(s, 3H),                                                      3.7(m, 2H), 3.75(d, 1H),                                                      4.45(d, 1H), 7.1(m, 3H),                                                      7.25(m, 1H), 7.35(d, 2H),                                                     7.6(d, 2H).                                     6   H  N(CH.sub.3)C(O)OC.sub.2 H.sub.5                                                                 121-123                                                                            0.88(t, 3H), 1.9(m, 1H),                                                      2.6(m, 3H), 3.5(s, 3H),                                                       3.66(s, 3H), 3.8(m, 3H),                                                      4.47(d, 1H), 7.11(m, 3H),                                                     7.25(m, 1H), 7.35(d, 2H),                                                     7.6(d, 2H).                                     7   6-F                                                                              N(CH.sub.3 )C(O)OC.sub.4 H.sub.9                                                                120  0.83(t, 3H), 1.2(m, 4H),                                                      1.85(m, 1H), 2.7(m, 2H),                                                      3.0(m, 1H), 3.5(s, 3H),                                                       3.66(s, 3H), 3.75(m, 3H),                                                     4.5(d, 1H), 7.0(m, 3H),                                                       7.35(d, 2H), 7.6(d, 3H).                        8   H  N(CH.sub.3)C(O)OcycloC.sub.6 H.sub.11                                                           175-176                                                                            0.6-1.7(m, 10H), 1.9(m, 1H),                                                  2.6-3.0(m, 3H), 3.51(s, 3H),                                                  3.65(s, 3H), 3.75(d, 1H),                                                     4.35(m, 1H), 4.45(d, 1H),                                                     7.1(m, 3H), 7.25(m, 1H),                                                      7.35(d, 2H), 7.6(d, 2H).                        9   H  N(CH.sub.3)C(O)OC.sub.8 H.sub.17                                                                144-145                                                                            0.88(t, 3H), 1.21(m, 12H),                                                    1.9(m, 1H), 2.7(m, 1H),                                                       2.9(m, 2H), 3.5(m, 3H),                                                       3.65(m, 3H), 3.75(m, 3H),                                                     4.5(d, 1H), 7.1(m, 3H),                                                       7.25(m, 1H), 7.35(d, 2H),                                                     7.6(d, 2H).                                    10   H  N(CH.sub.3)C(O)OC.sub.10 H.sub.21                                                               76-78                                                                              0.88(t, 3H), 1.25(m, 16H),                                                    1.9(m, 1H), 2.7(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                       3.66(s, 3H), 3.75(m, 3H),                                                     4.5(d, 1H), 7.15(m, 3H),                                                      7.25(m, 1H), 7.35(d, 2H),                                                     7.6(d, 2H).                                    11   6-F                                                                              N[CH(CH.sub.3).sub.2 ]C(O)C.sub.2 H.sub.5                                                       143.5                                                                              0.91(t, 3H), 1.27(d, 3H),                                                     1.35(d, 3H), 1.9(m, 1H),                                                      2.75(m, 2H), 3.05(m, 1H),                                                     3.67(s, 3H), 3.75(m, 3H),                                                     4.5(m, 2H), 7.25(m, 3H),                                                      7.45(d, 2H), 7.6(d, 2H).                       12   H  N(CH.sub.3)C(O)OC.sub.12 H.sub.25                                                               --   0.88(t, 3H), 1.26(m, 20H),                                                    1.9(m, 1H), 2.7(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                       3.66(s, 3H), 3.75(m, 3H),                                                     4.5(d,1 H), 7.1(m, 3H),                                                       7.25(m, 1H), 7.35(d, 2H),                                                     7.6(d, 2H).                                    13   H  N(CH.sub.3)C(O)OC.sub.6 H.sub.13                                                                --   0.88(t, 3H), 1.26(m, 8H),                                                     1.9(m, 1H), 2.7(m, 1H),                                                       2.9(m, 2H), 3.51(s, 3H),                                                      3.66(s, 3H), 3.75(m, 3H),                                                     4.5(d, 2H), 7.1(m, 3H),                                                       7.25(m, 1H), 7.35(d, 2H),                                                     7.6(d, 2H).                                    14   7-Cl                                                                             C(O)O-sec-C.sub.4 H.sub.9                                                                       132  0.88(t, 3H), 1.3(m, 3H),                                                      1.6(m, 2H), 1.9(m, 1H),                                                       2.6-3.0(m, 3H), 3.88(s, 3H),                                                  3.8(d, 1H), 4.5(d, 1H),                                                       5.0(m, 1H), 7.0(m, 3H),                                                       7.35(d, 2H), 7.6(d, 2H).                       15   7-Cl                                                                             N[CH(CH.sub.3).sub.2 ]C(O)OC.sub.2 H.sub.5                                                      152  0.9(t, 3H), 1.26(d, 3H),                                                      1.35(d, 3H), 1.9(m, 1H),                                                      2.7(m, 1H), 2.9(m, 2H),                                                       3.67(s, 3H), 3.8(m, 3H),                                                      4.5(m, 2H), 7.14(m, 2H),                                                      7.4(m, 3H), 7.6(d, 2H).                        16   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.2 H.sub.5                                                                 --   0.88(t, 3H), 1.9(m, 1H),                                                      2.65(m, 1H), 2.9(m, 2H),                                                      3.49(s, 3H), 3.66(s, 3H),                                                     3.8(m, 3H), 4.5(d, 1H),                                                       7.07(m, 3H), 7.35(d, 2H),                                                     7.6(d, 2H).                                    17   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.8 H.sub.17                                                                103-106                                                                            0.88(t, 3H), 1.23(m, 12H),                                                    1.9(m, 1H), 2.65(m, 1H),                                                      2.85(m, 2H), 3.5(s, 3H),                                                      3.66(s, 3H), 3.75(m, 3H),                                                     4.45(d, 1H), 7.05(m, 3H),                                                     7.35(d, 2H), 7.6(d, 2H).                       18   6-F                                                                              C(O)O-sec-C.sub.4 H.sub.9                                                                       125-126                                                                            0.9(m, 3H), 1.3(m, 5H),                                                       1.9(m, 1H), 2.75(m, 2H),                                                      3.0(m, 1H), 3.7(s, 3H),                                                       3.8(d, 1H), 4.5(d, 1H),                                                       5.0(m, 1H), 6.8(m, 1H),                                                       7.05(m, 2H), 7.45(d, 2H),                                                     7.6(d, 2H).                                    19   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.4 H.sub.9                                                                 125-127                                                                            0.82(m, 3H), 1.2(m, 4H),                                                      1.9(m, 1H), 2.65(m, 1H),                                                      2.85(m, 2H), 3.5(s, 3H),                                                      3.66(s, 3H), 3.75(m, 3H),                                                     4.45(d, 1H), 7.05(m, 3H),                                                     7.35(d, 2H), 7.6(d, 2H).                       20   7-Cl                                                                             N[CH(CH.sub.3).sub.2 ]C(O)OC.sub.4 H.sub.9                                                      --   0.84(t, 3H), 1.25(m, 10H),                                                    1.9(m, 1H), 2.65(m, 1H),                                                      3.66(s, 3H), 3.7(m, 3H),                                                      4.45(m, 2H), 7.15(m, 2H),                                                     7.4(m, 3H), 7.6(d, 2H).                        21   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.12 H.sub.25                                                               --   0.88(t, 3H), 1.2(m, 20H),                                                     1.9(m, 1H), 2.65(m, 1H),                                                      2.9(m, 2H), 3.5(s, 3H),                                                       3.67(s, 3H), 3.75(m, 3H),                                                     4.5(d, 1H), 7.05(m, 3H),                                                      7.35(d, 2H), 7.6(d, 2H).                       22   7-Cl                                                                             N(CH.sub.3)C(O)O-cycloC.sub.6 H.sub.11                                                          87-91                                                                              0.8-1.7(Broad m, 10H),                                                        2.65(m, 1H), 2.9(m, 2H),                                                      3.51(s, 3H), 3.66(s, 3H),                                                     3.75(d, 1H), 4.35(m, 1H),                                                     4.45(d, 1H), 7.05(m, 3H),                                                     7.35(d, 2H), 7.6(d, 2H).                       23   7-Cl                                                                             N(CH.sub.3)C(O)(CH.sub.2).sub.2 OC.sub.4 H.sub.9                                                --   0.9(t, 3H), 1.4(m, 4H)                                                        1.9(m, 1H), 2.7(m, 1H)                                                        2.9(m, 2H), 3.3(m, 4H)                                                        3.5(s, 3H), 3.67(s, 3H),                                                      3.9(m, 3H), 4.5(d, 1H),                                                       7.1(m, 3H), 7.4(d, 2H),                                                       7.6(d, 2H).                                    24   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.14 H.sub.29                                                               --   0.87(t, 3H), 1.26(m, 24H),                                                    1.9(m, 1H), 2.65(m, 1H),                                                      2.9(m, 2H), 3.5(s, 3H),                                                       3.68(s,3 H), 3.75(m, 3H),                                                     4.47(d, 1H), 7.05(m, 3H),                                                     7.35(d, 2H), 7.57(d, 2H).                      25   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.16 H.sub.33                                                               --   0.87(t, 3H), 1.26(m, 28H),                                                    1.9(m, 1H), 2.65(m, 1H),                                                      2.9(m, 2H), 3.5(s, 3H),                                                       3.67(s,3 H), 3.75(m, 3H),                                                     4.47(d,1 H), 7.05(m, 3H),                                                     7.35(d, 2H), 7.6(d, 2H).                       26   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.18 H.sub.37                                                               --   0.9(t, 3H), 1.26(m, 32H),                                                     1.9(m, 1H), 2.65(m, 1H),                                                      2.9(m, 2H), 3.5(s, 3H),                                                       3.67(m, 3H), 3.75(m, 3H),                                                     4.5(d, 1H), 7.05(m, 3H),                                                      7.35(d, 2H), 7.6(d, 2H).                       27   7-Cl                                                                             N(CH.sub.3)C(O)OC.sub.22 H.sub.45                                                               --   0.88(t, 3H), 1.26(m, 40H),                                                    1.9(m, 1H), 2.65(m, 1H),                                                      2.9(m, 2H), 3.5(s, 3H),                                                       3.65(m, 3H), 3.75(m, 3H),                                                     4.48(d, 1H), 7.06(m, 3H),                                                     7.35(d, 2H), 7.6(d, 2H).                       28   7-Cl                                                                             N(CH.sub.3)C(O)(CH.sub.2).sub.2 O(CH.sub.2).sub.2 OC.sub.4                    H.sub.9           --   0.91(t, 3H), 1.4(m, 4H),                                                      1.9(m, 1H), 2.7(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                       3.67(s, 3H), 3.7(m, 9H),                                                      4.0(m, 1H), 4.2(m, 1H),                                                       4.5(d, 1H), 7.6(m, 3H),                                                       7.4(d, 2H), 7.6(d, 2H).                        __________________________________________________________________________

EXAMPLE 28(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)aminothiol]-1H-pyrazole-3-carboxamide

Step A: Ethyl (chlorosulfenyl) (1-methylethyl)-carbamate

To a solution of ethyl (1-methylethyl)carbamate (13.1 g, 0.1 mol) in 100ml of methylene chloride cooled to 0° C. was added sulfur dichloride(11.3 g, 0.11 mol) in one portion. While maintaining the temperature ofthe mixture at 0° C., pyridine (8.7 g, 0.11 mol) was added dropwise overeleven minutes. After complete addition of the pyridine the temperaturewas allowed to rise to room temperature and stirring was continued foradditional 1.5 hours. The mixture was let stand overnight. Methylenechloride was evaporated under vacuum and 100 ml hexane was added.Filteration of pyridine hydrochloride and evaporation of hexane resultedin an orange oil which was distilled in a Kugelrohr apparatus to give12.5 g of the title Compound B.P.: 64°-80 ° (bath temp.)

Step B:1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N-[4-trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)-aminothio]-1H-pyrazole-3-carboxamide

To a solution of1-(4-chlorophenyl)-5-(4-fluorophenyl)4,5-dihydro-N-]4-(trifluoromethyl)phenyl]-1H-pyraole-3-carboxamide(0.95 g, 0.002 mol) in 10 ml of methylene chloride cooled to 0° C. wasadded triethylamine (0.25 g) followed by the title compound of Step A(0.5 g, 0.0025 mol). The reaction mixture was allowed to warm to roomtemperature with stirring for one hour. Methylene chloride (50 ml) wasadded and the mixture was washed with water, dried over magnesiumsulfate and filtered. The solvent was evaporated and the residue waspurified by silica gel column chromatograph using hexane:ether (2:1) asthe eluent. Obtained 1.0 g of the title compound, m.p.: 136°-137° C.,'H-NMR (CDCl₃); δ7.7 (d,2H), 7.4 (δ, 2H), 7.0 (m,6H), 6.3 (d,2H), 5.2 (dof d, 1H), 4.5 (m,1H), 3.75 (m,3H), 3.05 (d of d, 1H) 1.3 (d of d, 6H),0.87 (t,3H).

EXAMPLE 30 3,4-bis-(4-chlorophenyl)-N[4-(trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)-aminthiol]-4,5-dihydro-1H-pyrazole-1-carboxamide

To a solution of3,4-bis-(4-chlorophenyl)-N-[4-(trifluoromethyl)phenyl)]-4,5-dihydro-1H-pyrazole-1-carboxamide(0.466 g, 0.001 mol) in 5 ml of methylene chloride cooled to 0° C. wasadded 0.3 g of triethylamine and ethyl (chlorosulfenyl) (1-methylethyl)carbamate (0.5 g). The mixture was allowed to warm to room temperatureand let stand overnight. 20 ml CH₂ Cl₂ was added and the mixture waswashed with water and dried over MgSO₄ and filtered. The solvent wasevaporated under vacuum. The residue was purified by silica gel columnchromatography using CH₂ Cl₂ :Butylchloride mixture (1:1) as a primaryeluent followed by ether. The title compound was obtained in high purity(0.28 g), m.p.: 65°-68° C.

¹ H-NMR (CDCl₃), δ7.65 (d,2H), 7.5 (d,2H), 7.27 (d, 2H), 7.17 (S,4), 7.0(d,2H), 4.6-4.3 (m,3H), 3.95 (d of d, 1H), 3.8 (q,2H), 1.3 (m,6H), 0.95(T,3H).

The following additional Examples (Tables B and C) employed proceduressimilar to those described in the previous Examples 29 and 30 or in thedisclosed literature.

                                      TABLE B                                     __________________________________________________________________________     ##STR11##                                                                    Example                                                                            X               m.p. °C.                                                                    'H-NMR(δ in ppm) in CDCl.sub.3                __________________________________________________________________________    31   N[CH(CH.sub.3).sub.2 ]C(O)OC.sub.4 H.sub.9                                                    165-170                                                                            7.23(d, 2H), 7.4(d, 2H),                                                      7.0(M, 6H), 6.3(d, 2H),                                                       5.2(d of d, 1H), 4.5                                                          (M, 1H), 3.75(M, 3H),                                                         3.1(d of d, 1H), 1.4-1.1                                                      (M, 10H), .85(t, 3H)                                32   N[CH(CH.sub.3)(C.sub.2 H.sub.5)]C(O)OC.sub.2 H.sub.5                                          --   7.23(d, 2H), 7.4(d, 2H),                                                      7.0(M, 6H), 6.3(d, 2H),                                                       5.2(d of d, 1H), 4.5                                                          (M, 1H), 3.75(M, 3H),                                                         3.1(d of d, 1H), 1.8-1.1                                                      (M, 5H), 0.9(M, 6H).                                33   C(O)OCH(CH.sub.3)(C.sub.2 H.sub.5 )                                                           159-161                                                                            7.25(d, 2H), 7.55(d, 2H),                                                     7.0(M, 6H), 6.25(d, 2H),                                                      5.2(d of d, 1H), 5.0                                                          (M, 1H), 3.75(d of d,                                                         1H), 3.1(d of d, 1H),                                                         1.65(M, 2H), 1.28(d,                                                          3H), 0.9(t, 3H).                                    34   N(CH.sub.3)C(O)O(cyclo C.sub.6 H.sub.11)                                                      147-150                                                                            7.2(d, 2H), 7.4(d, 2H),                                                       7.0(M, 6H), 6.3(d, 2H),                                                       5.2(d of d, 1H), 4.3                                                          (M, 1H), 3.7(d of d, 1H),                                                     3.5(5, 3H), 3.2(d of d,                                                       1H), 1.8-0.9(M, 10H).                               __________________________________________________________________________

                                      TABLE C                                     __________________________________________________________________________     ##STR12##                                                                    EXAMPLE                                                                              Q            R.sub.3                                                                         R.sub.1                                                                          m.p. °C.                                                                    'H-NMR(δ in ppm)                          __________________________________________________________________________    35     SN(CH.sub.3)C(O)O-sec-C.sub.4 H.sub.9                                                      Cl                                                                              CF.sub.3                                                                         83-84                                                                              7.8-6.9(m, 12H),                                                              4.6-4.3(M, 3H), 4.0                                                           (M, 1H), 3.52(S, 3H),                                                         1.25(M, 2H), 1.0-0.7                                                          (M, 6H).                                        36     SC(O)O-sec-C.sub.4 H.sub.9                                                                 Cl                                                                              CF.sub.3                                                                         78-80                                                                              7.7-7.0(M, 12H), 5.0                                                          (M, 1H), 4.45(M, 2H),                                                         4.0(M, 1H), 1.6(M,                                                            2H), 1.3(d, 3H), 0.9                                                          (t, 3H).                                        37     SC(O)O-sec-C.sub.4 H.sub.9                                                                 Cl                                                                              Cl 66-69                                                                              7.4-6.9(M, 12H), 5.0                                                          (M, 1H), 4.5(M, 2H),                                                          4.0(M, 1H), 1.6(M,                                                            2H), 1.28(d, 3H), 0.9                                                         (M, 3H).                                        38     CO.sub.2 CH.sub.3                                                                          Cl                                                                              CF.sub.3                                                                         151-154                                                                            7.7-7.0(m, 12H), 4.7                                                          (d, d, 1H), 4.5(d, d, 1H),                                                    4.1(d, d, 1H), 3.86                                                           (s, 3H).                                        39     COCH.sub.3   F CF.sub.3                                                                         157-159                                                                            7.7-7.0(m, 12H), 4.7                                                          (d, d, 1H), 4.5(d, d, 1H),                                                    4.1(d, d, 1H), 3.86                                                           (s, 3H).                                        40     SN(CH(CH.sub.3).sub.2)SO.sub.2 C.sub.2 H.sub.5                                             Cl                                                                              CF.sub.3                                                                         oil  7.65(m, 2H), 7.25(m, 4H),                                                     7.05(m, 1H), 4.6-3.9                                                          (m, 3H), 3/65(m, 1H), 3.03                                                    (q, 2H), 1.36(t, 3H), 1.24                                                    (d, 6H).                                        41     COCH.sub.3   Cl                                                                              CF.sub.3                                                                         166-168                                                                            7.6-7.0(m, 12H),                                                              4.7-4.0(m, 3H),                                                               2.3(s, 3H).                                     42     COCH.sub.3   F Cl 187-190                                                                            7.5- 7.0(m, 12H),                                                             4.6(m, 1H), 4.4                                                               (m, 1H), 4.0(m, 1H),                                                          2.26(s, 3H).                                    43     COCH.sub.3   F Br 181-186                                                                            7.6-7.0(m, 12H),                                                              4.65(m, 1H),                                                                  4.4(m, 1H),                                                                   4.0(m, 1H),                                                                   2.25(s, 3H).                                    44     CO.sub.2 Me  F CF.sub.3                                                                         80-86                                                45     COPh         F CF.sub.3                                                                         176-179                                              46     COEt         Cl                                                                              CF.sub.3                                                                         169-170                                              47     C(O)C(O).sub.2 Et                                                                          Cl                                                                              CF.sub.3                                                                         166-167                                              48     CO-n-Bu      Cl                                                                              CF.sub.3                                                                         60-62                                                49     COCH.sub.3   Cl                                                                              Cl 205-206                                              50     COEt         Cl                                                                              Cl 157-158                                              51     CO.sub.2 Me  Cl                                                                              Cl 162-166                                              52     4-ClPhCO     Cl                                                                              CF.sub.3                                                                         209-211                                              53     t-BuCO       Cl                                                                              CF.sub.3                                                                         140-145                                              54     PhOCO        Cl                                                                              CF.sub.3                                                                         150-155                                              __________________________________________________________________________

EXAMPLE 55N-acetyl-3,4-bis(4-chlorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-1-carboxamide

The compound of Step D of Example 6 (0.65 g) was dissolved intetrahydrofuran (20 ml) and treated with 60% sodium hydride in oil (0.12g). After the evolution of hydrogen was complete (30 minutes), aceticanhydride (0.6 ml) was added and the mixture was stirred at roomtemperature for 16 hours. The reaction was diluted with saturatedaqueous ammonium chloride solution (15 ml) and ethyl acetate (30 ml).The organic layer was dried with magnesium sulfate and evaporated. Theresidue was subjected to chromatography on silica gel with hexanes/ethylacetate (3:1) as eluent. Addition of methanol (10 ml) to the productgave, after filtration, the title compound (0.4 g). m.p. 166° to 168° C.

NMR (CDCl₃) 7.6-7.0 (m, ArH, 12H), 4.7-4.0 (m, 3H, CH and CH₂), 2.3 (s,COCH₃, 3H).

                  TABLE 1                                                         ______________________________________                                         ##STR13##                                                                    R.sub.1                                                                              R.sub.2  B        R.sub.8                                                                             R.sub.9                                        ______________________________________                                        4-CF.sub.3                                                                           5-Cl     H        Me    OEt                                            4-CF.sub.3                                                                           5-Cl     Me       Me    OEt                                            4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    OEt                                            4-Cl   H        CO.sub.2 Me                                                                            Me    OEt                                            4-Br   H        CO.sub.2 Me                                                                            Me    OEt                                            4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    OEt                                            4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    OEt                                            4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    OEt                                            4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    OEt                                            4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    OEt                                            4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    OEt                                            4-CF.sub.3                                                                           5-Cl     Ph       Me    OEt                                            4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    OEt                                            4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    OEt                                            4-CF.sub.3                                                                           5-Cl     H        Me    O-n-Bu                                         4-CF.sub.3                                                                           4-F      H        Me    O-n-Bu                                         4-CF.sub.3                                                                           H        Me       Me    O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     Me       Me    O-n-Bu                                         4-CF.sub.3                                                                           5-Br     Me       Me    O-n-Bu                                         4-CF.sub.3                                                                           4-F      Me       Me    O-n-Bu                                         4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Cl   H        CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Br   H        CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Br   5-Cl     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Cl   5-Br     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Br   5-Br     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Cl   4-F      CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-Br   4-F      CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     Ph       Me    O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    O-n-Bu                                         4-CF.sub. 3                                                                          5-Cl     Me       Me    O-n-hexyl                                      4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Cl   H        CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Br   H        CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Br   5-Cl     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Br   5-Br     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Cl   4-F      CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-Br   4-F      CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-Cl     Ph       Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    O-n-hexyl                                      4-CF.sub.3                                                                           5-Cl     Me       Me    O-n-octyl                                      4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Cl   H        CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Br   H        CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Br   5-Cl     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Br   5-Br     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Cl   4-F      CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-Br   4-F      CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    O-n-octyl                                      4-CF.sub.3                                                                           5-Cl     Ph       Me    O-n-octyl                                      4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    O-n-octyl                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    O-n-octyl                                      4-CF.sub.3                                                                           5-Cl     Me       Me    O-n-decyl                                      4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Cl   H        CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Br   H        CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Br   5-Cl     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Br   5-Br     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Cl   4-F      CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-Br   4-F      CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    O-n-decyl                                      4-CF.sub.3                                                                           5-Cl     Ph       Me    O-n-decyl                                      4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    O-n-decyl                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    O-n-decyl                                      4-CF.sub.3                                                                           5-Cl     Me       Me    O-n-dodecyl                                    4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Cl   H        CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Br   H        CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Br   5-Cl     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Cl   5-Br     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Br   5-Br     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Cl   4-F      CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-Br   4-F      CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-Cl     Ph       Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    O-n-dodecyl                                    4-CF.sub.3                                                                           5-Cl     Me       Me    O-sec-Bu                                       4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Cl   H        CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Br   H        CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Br   5-Cl     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Cl   5-Br     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Br   5-Br     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Cl   4-F      CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-Br   4-F      CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-Cl     Ph       Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    O-sec-Bu                                       4-CF.sub.3                                                                           5-Cl     Me       Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Cl   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Br   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Br   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Cl   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Br   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Cl   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-Br   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                          4-F      CO.sub. 2 Me                                                                           Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-Cl     Ph       Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                           5-Cl     Me       Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Cl   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Br   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Br   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Cl   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Br   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Cl   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-Br   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-Cl     Ph       Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           5-Cl     Me       Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Cl   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Br   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Br   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Cl   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Br   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Cl   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-Br   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-Cl     Ph       Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                           5-Cl     Me       Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-Cl   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-Br   H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub. 2 Et                         4-Br   5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-Cl   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-Br   5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-Cl   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-Br   4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           5 CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           5-Cl     Ph       Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           H        H        Me    F                                              4-CF.sub.3                                                                           5-Cl     H        Me    F                                              4-CF.sub.3                                                                           5-Br     H        Me    F                                              4-CF.sub.3                                                                           4-F      H        Me    F                                              4-CF.sub. 3                                                                          H        Me       Me    F                                              4-CF.sub.3                                                                           5-Cl     Me       Me    F                                              4-CF.sub.3                                                                           5-Br     Me       Me    F                                              4-CF.sub.3                                                                           4-F      Me       Me    F                                              4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me    F                                              4-Cl   H        CO.sub.2 Me                                                                            Me    F                                              4-Br   H        CO.sub.2 Me                                                                            Me    F                                              4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me    F                                              4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    F                                              4-Cl   5-Cl     CO.sub.2 Me                                                                            Me    F                                              4-Br   5-Cl     CO.sub.2 Me                                                                            Me    F                                              4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    F                                              4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    F                                              4-Cl   5-Br     CO.sub.2 Me                                                                            Me    F                                              4-Br   5-Br     CO.sub.2 Me                                                                            Me    F                                              4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    F                                              4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    F                                              4-Cl   4-F      CO.sub.2 Me                                                                            Me    F                                              4-Br   4-F      CO.sub.2 Me                                                                            Me    F                                              4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    F                                              4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me    F                                              4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me    F                                              4-CF.sub.3                                                                           5-Cl     Ph       Me    F                                              4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  Me    F                                              4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            Me    F                                              4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    piperidino                                     4-CF.sub.3                                                                           4-F      Me       Me    piperidino                                     4-CF.sub.3                                                                           Cl       CO.sub.2 Me                                                                            Me    morpholino                                     4-OCF.sub.3                                                                          Cl       CO.sub.2 Me                                                                            Me    morpholino                                     4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    n-Pr                                           4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me    n-Pr                                           4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            Me    sec-Bu                                         4-Cl   5-Br     CO.sub.2 Me                                                                            Me    sec-Bu                                         4-Br   5-Br     CO.sub.2 Me                                                                            Me    sec-Bu                                         4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me    sec-Bu                                         4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me    4-Cl-Ph                                        4-Cl   4-F      CO.sub.2 Me                                                                            Me    4-Cl-Ph                                        4-Br   4-F      CO.sub.2 Me                                                                            Me    4-Cl-Ph                                        4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me    4-Cl-Ph                                        4-CF.sub.3                                                                           5-Cl     Me       Et    OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Et    NEt.sub.2                                      4-Cl   H        CO.sub.2 Me                                                                            Et    NEt.sub.2                                      4-Br   H        CO.sub.2 Me                                                                            Et    NEt.sub.2                                      4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Et    NEt.sub.2                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Et    2,6-di-Me-morpholino                           4-Cl   5-Cl     CO.sub.2 Me                                                                            Et    2,6-di-Me-morpholino                           4-Br   5-Cl     CO.sub.2 Me                                                                            Et    2,6-di-Me-morpholino                           4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Et    2,6-di-Me-morpholino                           4-CF.sub.3                                                                           5-Cl     Me       iPr   OEt                                            4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            iPr   OEt                                            4-Cl   H        CO.sub.2 Me                                                                            iPr   OEt                                            4-Br   H        CO.sub.2 Me                                                                            iPr   OEt                                            4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            iPr   OEt                                            4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            iPr   OEt                                            4-Cl   5-Cl     CO.sub.2 Me                                                                            iPr   OEt                                            4-Br   5-Cl     CO.sub.2 Me                                                                            iPr   OEt                                            4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            iPr   OEt                                            4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            iPr   OEt H -4-Cl 5-Br CO.sub.2 Me iPr OEt           4-Br   5-Br     CO.sub.2 Me                                                                            iPr   OEt                                            4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            iPr   OEt                                            4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            iPr   OEt                                            4-Cl   4-F      CO.sub.2 Me                                                                            iPr   OEt                                            4-Br   4-F      CO.sub.2 Me                                                                            iPr   OEt                                            4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            iPr   OEt                                            4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            iPr   OEt                                            4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            iPr   OEt                                            4-CF.sub.3                                                                           5-Cl     Ph       iPr   OEt                                            4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  iPr   OEt                                            4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            iPr   OEt                                            4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    ON(CH.sub.3)SCH.sub.e                          4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    2,3-dihydro-2,2-dimethyl-                                                     benzofuranyl oxy-7                             4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me    1-naphthoxy                                    4-CF.sub.3                                                                           5-Cl     Me       iPr   O-n-Bu                                         4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Cl   H        CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Br   H        CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Cl   5-Cl     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Br   5-Cl     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Cl   5-Br     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Br   5-Br     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Cl   4-F      CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-Br   4-F      CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            iPr   O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     Ph       iPr   O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  iPr   O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            iPr   O-n-Bu                                         4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            iPr   OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            iPr   OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            iPr   OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            iPr   OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            iPr   NMe.sub.2                                      4-Cl   H        CO.sub.2 Me                                                                            iPr   NMe.sub.2                                      4-Br   H        CO.sub.2 Me                                                                            iPr   NMe.sub.2                                      4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            iPr   NMe.sub.2                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            iPr   NEt.sub.2                                      4-Cl   5-Cl     CO.sub.2 Me                                                                            iPr   NEt.sub.2                                      4-Br   5-Cl     CO.sub.2 Me                                                                            iPr   NEt.sub.2                                      4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            iPr   NEt.sub.2                                      4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            iPr   piperidino                                     4-Cl   5-Br     CO.sub.2 Me                                                                            iPr   piperidino                                     4-Br   5-Br     CO.sub.2 Me                                                                            iPr   piperidino                                     4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            iPr   piperidino                                     4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            iPr   Et                                             4-Cl   4-F      CO.sub.2 Me                                                                            iPr   Et                                             4-Br   4-F      CO.sub.2 Me                                                                            iPr   Et                                             4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            iPr   Et                                             4-CF.sub.3                                                                           H        H        CH.sub.2 Ph                                                                         OEt                                            4-CF.sub.3                                                                           5-Cl     H        CH.sub.2 Ph                                                                         O-n-octyl                                      4-CF.sub.3                                                                           5-Br     H        CH.sub.2 Ph                                                                         OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                           H        Me       CH.sub.2 Ph                                                                         NEt.sub.2                                      4-CF.sub.3                                                                           5-Cl     Me       CH.sub.2 Ph                                                                         morpholino                                     4-CF.sub.3                                                                           5-Br     Me       CH.sub.2 Ph                                                                         4-Cl-Ph                                        4-CF.sub.3                                                                           4-F      Me       CH.sub.2 Ph                                                                         Et                                             4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         O-n-Bu                                         4-Cl   H        CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         O-iPr                                          4-Br   H        CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         NMe.sub.2                                      4-CF.sub. 3                                                                          5-Cl     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         piperidino                                     4-Cl   5-Cl     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         Ph                                             4-Br   5-Cl     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         4-NO.sub.2 -Ph                                 4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         Bu                                             4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         O-n-hexyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         O-sec-Bu                                       4-Br   5-Br     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         NMe.sub.2                                      4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         2,6-di-Me-morpholino                           4-Cl   4-F      CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         3-Br-Ph                                        4-Br   4-F      CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         4-Me-Ph                                        4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         nPr                                            4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         Me                                             4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            CH.sub.2 Ph                                                                         OEt                                            4-CF.sub.3                                                                           5-Cl     Ph       CH.sub.2 Ph                                                                         O-n-Bu                                         4-CF.sub.3                                                                           5-Cl     4-Cl-Ph  CH.sub.2 Ph                                                                         O-n-octyl                                      4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            CH.sub.2 Ph                                                                         OCH.sub.2 CCl.sub.3                            ______________________________________                                    

                  TABLE 2                                                         ______________________________________                                         ##STR14##                                                                    R.sub.1 R.sub.2 B         R.sub.8                                                                            R.sub.9                                        ______________________________________                                        4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Cl    H       CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Br    H       CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Cl    5-Cl    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Br    5-Cl    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Cl    5-Br    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Br    5-Br    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Cl    4-F     CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-Br    4-F     CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             Me   NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    Ph        Me   NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    4-Cl-Ph   Me   NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             Me   NMe.sub.2                                      4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-Cl    H       CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-Br    H       CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-Cl    5-Cl    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-Br    5-Cl    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-Cl    5-Br    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-Br    5-Br    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             Me   NEt.sub.2                                      4-Cl    4-F     CO.sub.2 Me                                                                             Me   piperidino                                     4-Br    4-F     CO.sub.2 Me                                                                             Me   piperidino                                     4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             Me   piperidino                                     4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             Me   piperidino                                     4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             Me   piperidino                                     4-CF.sub.3                                                                            5-Cl    Ph        Me   piperidino                                     4-CF.sub.3                                                                            5-Cl    4-Cl-Ph   Me   piperidino                                     4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             Me   piperidino                                     4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             Me   C.sub.2 H.sub.5                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             Me   C.sub.2 H.sub.5                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             Me   C.sub.2 H.sub.5                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             Me   C.sub.2 H.sub.5                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             Me   n-hexyl                                        4-Cl    H       CO.sub.2 Me                                                                             Me   n-hexyl                                        4-Br    H       CO.sub.2 Me                                                                             Me   n-hexyl                                        4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             Me   n-hexyl                                        4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             Me   Ph                                             4-Cl    5-Cl    CO.sub.2 Me                                                                             Me   Ph                                             4-Br    5-Cl    CO.sub.2 Me                                                                             Me   Ph                                             4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             Me   Ph                                             4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             Me   4-Cl-Ph                                        4-Cl    5-Br    CO.sub.2 Me                                                                             Me   4-Cl-Ph                                        4-Br    5-Br    CO.sub.2 Me                                                                             Me   4-Cl-Ph                                        4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             Me   4-Cl-Ph                                        4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             Me   4-Me-Ph                                        4-Cl    4-F     CO.sub.2 Me                                                                             Me   4-Me-Ph                                        4-Br    4-F     CO.sub.2 Me                                                                             Me   4-Me-Ph                                        4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             Me   4-Me-Ph                                        4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             Me   n-Bu                                           4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             Me   n-Bu                                           4-CF.sub.3                                                                            5-Cl    Ph        Me   n-Bu                                           4-CF.sub.3                                                                            5-Cl    4-Cl-Ph   Me   n-Bu                                           4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             Me   n-Bu                                           4-CF.sub.3                                                                            H       H         Et   NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    H         Et   NMe.sub.2                                      4-CF.sub.3                                                                            5-Br    H         Et   NMe.sub.2                                      4-CF.sub.3                                                                            4-F     H         Et   NMe.sub.2                                      4-CF.sub.3                                                                            H       Me        Et   NEt.sub.2                                      4-CF.sub.3                                                                            5-Cl    Me        Et   NEt.sub.2                                      4-CF.sub.3                                                                            5-Br    Me        Et   NEt.sub.2                                      4-CF.sub.3                                                                            4-F     Me        Et   NEt.sub.2                                      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             Et   morpholino                                     4-Cl    5-Cl    CO.sub.2 Me                                                                             Et   morpholino                                     4-Br    5-Cl    CO.sub.2 Me                                                                             Et   morpholino                                     4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             Et   morpholino                                     4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             Et   iPr                                            4-Cl    5-Cl    CO.sub.2 Me                                                                             Et   iPr                                            4-Br    5-Cl    CO.sub.2 Me                                                                             Et   iPr                                            4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             Et   iPr                                            4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             Et   n-Bu                                           4-Cl    5-Br    CO.sub.2 Me                                                                             Et   n-Bu                                           4-Br    5-Br    CO.sub.2 Me                                                                             Et   n-Bu                                           4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             Et   n-Bu                                           4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             Et   Ph                                             4-Cl    4-F     CO.sub.2 Me                                                                             Et   Ph                                             4-Br    4-F     CO.sub.2 Me                                                                             Et   Ph                                             4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             Et   Ph                                             4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Cl    H       CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Br    H       CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Cl    5-Cl    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Br    5-Cl    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Cl    5-Br    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Br    5-Br    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Cl    4-F     CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-Br    4-F     CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             iPr  NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    Ph        iPr  NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    4-Cl-Ph   iPr  NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             iPr  NMe.sub.2                                      4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             iPr  2,6-di-Me-morpholino                           4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             iPr  2,6-di-Me-morpholino                           4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             iPr  2,6-di-Me-morpholino                           4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             iPr  2,6-di-Me-morpholino                           4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             iPr  piperidino                                     4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             iPr  piperidino                                     4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             iPr  Et                                             4-Cl    5-Cl    CO.sub.2 Me                                                                             iPr  Et                                             4-Br    5-Cl    CO.sub.2 Me                                                                             iPr  Et                                             4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             iPr  Et                                             4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             iPr  n-Bu                                           4-Cl    5-Br    CO.sub.2 Me                                                                             iPr  n-Bu                                           4-Br    5-Br    CO.sub.2 Me                                                                             iPr  n-Bu                                           4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             iPr  n-Bu                                           4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             iPr  Ph                                             4-Cl    4-F     CO.sub.2 Me                                                                             iPr  Ph                                             4-Br    4-F     CO.sub.2 Me                                                                             iPr  Ph                                             4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             iPr  Ph                                             4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             iPr  4-Cl-Ph                                        4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             iPr  4-Cl-Ph                                        4-CF.sub.3                                                                            5-Cl    Ph        iPr  4-Cl-Ph                                        4-CF.sub.3                                                                            5-Cl    4-Cl-Ph   iPr  4-Cl-Ph                                        4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             iPr  4-Cl-Ph                                        ______________________________________                                    

                  TABLE 3                                                         ______________________________________                                         ##STR15##                                                                    R.sub.1                                                                              R.sub.2  B        R.sub.8                                                                            Y'   Y'R.sub.10                                                                           Y'R.sub.11                          ______________________________________                                        4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-Cl   H        CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-Br   H        CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-Cl   5-Cl     CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-Br   5-Cl     CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Br     CO.sub. 2 Me                                                                           tBu  S    OEt    OEt                                 4-Cl   5-Br     CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-Br   5-Br     CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-Cl   4-F      CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-Br   4-F      CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     Ph       tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     4-ClPh   tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            tBu  S    OEt    OEt                                 4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     Ph       tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub. 2 O          4-CF.sub.3                                                                           5-Cl     4-ClPh   tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Cl   H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Br   H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Cl   5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Br   5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Cl   5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Br   5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Cl   4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-Br   4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           5-Cl     Ph       tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           5-Cl     4-ClPh   tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O              4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Cl   H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Br   H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Cl   5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Br   5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Cl   5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Br   5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Cl   4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-Br   4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl     Ph       tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl     4-ClPh   tBu  S    OCH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                          H        CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Cl   H        CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Br   H        CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Cl   5-Cl     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Br   5-Cl     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Cl   5-Br     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Br   5-Br     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Cl   4-F      CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-Br   4-F      CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     Ph       iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     4-ClPh   iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            iPr  S    OEt    OEt                                 4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   H        CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   H        CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   5-Cl     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   5-Cl     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   5-Br     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   5-Br     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   4-F      CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   4-F      CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     Ph       iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     4-ClPh   iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Cl   H        CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Br   H        CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Cl   5-Cl     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Br   5-Cl     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-CF.sub. 3                                                                          5-Br     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Cl   5-Br     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Br   5-Br     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Cl   4-F      CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-Br   4-F      CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            Me   S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     Ph       Me   S    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     4-ClPh   Me   S    OEt    OEt                                 4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Cl   H        CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Br   H        CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Cl   5-Cl     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Br   5-Cl     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Cl   5-Br     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Br   5-Br     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Cl   4-F      CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-Br   4-F      CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     Ph       tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     4-ClPh   tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            tBu  O    OEt    OEt                                 4-CF.sub.3                                                                           H        CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   H        CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   H        CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          H        CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   5-Cl     CO.sub.2 Me                                                                            tBu  O    OCH.sub. 2 C(Me).sub.2 CH.sub.2 O          4-Br   5-Cl     CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          5-Cl     CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   5-Br     CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   5-Br     CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          5-Br     CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           4-F      CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Cl   4-F      CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-Br   4-F      CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-OCF.sub.3                                                                          4-F      CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-CF.sub.3                                                                             CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-F      CO.sub.2 Me                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     Ph       tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     4-ClPh   tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O           4-CF.sub.3                                                                           5-Cl     CO.sub.2 Et                                                                            tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2             ______________________________________                                                                           O                                      

                  TABLE 4                                                         ______________________________________                                         ##STR16##                                                                    R.sub.1 R.sub.2 B         R.sub.8                                                                            Y'   R.sub.10                                                                           Y'R.sub.11                           ______________________________________                                        4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Cl    H       CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Br    H       CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Cl    5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Br    5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Cl    5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Br    5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Cl    4-F     CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-Br    4-F     CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    Ph        iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    iPr  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             iPr  O    Et   OEt                                  4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Cl    H       CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Br    H       CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Cl    5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Br    5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Cl    5-Br    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Br    5-Br    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Cl    4-F     CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-Br    4-F     CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    Ph        iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    4-ClPh    iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             iPr  O    Et   O-iPr                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Cl    H       CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Br    H       CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Cl    5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Br    5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Cl    5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Br    5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Cl    4-F     CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-Br    4-F     CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             iPr  O    Et   OPh                                  4-CF.sub.3                                                                            5-Cl    Ph        iPr  O    Et   OPh                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    iPr  O    Et   OPh                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             iPr  O    Et   OPh                                  4-Br    4-F     CO.sub.2 Me                                                                             iPr  O    Ph   OEt                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             iPr  O    Ph   OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             iPr  O    Ph   OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             iPr  O    Ph   OEt                                  4-CF.sub.3                                                                            5-Cl    Ph        iPr  O    Ph   OEt                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    iPr  O    Ph   OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             iPr  O    Ph   OEt                                  4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Cl    H       CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Br    H       CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Cl    5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Br    5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Cl    5-Br    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Br    5-Br    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Cl    4-F     CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-Br    4-F     CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             tBu  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    Ph        tBu  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  O    Et   OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             tBu  O    Et   OEt                                  4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Cl    H       CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Br    H       CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Cl    5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Br    5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Cl    5-Br    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Br    5-Br    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Cl    4-F     CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-Br    4-F     CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    Ph        tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             tBu  O    Et   O-iPr                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             tBu  S    Et   OPh                                  4-Cl    H       CO.sub.2 Me                                                                             tBu  S    Ph   OEt                                  4-Br    H       CO.sub.2 Me                                                                             tBu  S    Ph   O-iPr                                4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                             tBu  S    Ph   OPh                                  4-Br    5-Br    CO.sub.2 Me                                                                             iPr  S    iPr  OEt                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             iPr  S    iPr  O-iPr                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             iPr  S    iPr  OPh                                  4-Cl    4-F     CO.sub.2 Me                                                                             iPr  S    nPr  OEt                                  4-Br    4-F     CO.sub.2 Me                                                                             iPr  S    nPr  O-iPr                                4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                             iPr  S    nPr  OPh                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                            CO.sub.2 Me                                                                             tBu  S    Me   OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             tBu  S    Me   O-iPr                                4-CF.sub.3                                                                            5-Cl    Ph        tBu  S    Me   OPh                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  S    Me   O-sec-Bu                             4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                             tBu  S    Me   O-nPr                                ______________________________________                                    

                  TABLE 5                                                         ______________________________________                                         ##STR17##                                                                    R.sub.1    R.sub.2  B          R.sub.10                                                                             R.sub.11                                ______________________________________                                        4-CF.sub.3 H        CO.sub.2 Me                                                                              Et     Et                                      4-Cl       H        CO.sub.2 Me                                                                              Et     Et                                      4-Br       H        CO.sub.2 Me                                                                              Et     Et                                      4-OCF.sub.3                                                                              H        CO.sub.2 Me                                                                              Et     Et                                      4-CF.sub.3 5-Cl     CO.sub.2 Me                                                                              Et     Et                                      4-Cl       5-Cl     CO.sub.2 Me                                                                              Et     Et                                      4-Br       5-Cl     CO.sub.2 Me                                                                              Et     Et                                      4-OCF.sub.3                                                                              5-Cl     CO.sub.2 Me                                                                              Et     Et                                      4-CF.sub.3 5-Br     CO.sub.2 Me                                                                              Et     Et                                      4-Cl       5-Br     CO.sub.2 Me                                                                              Et     Et                                      4-Br       5-Br     CO.sub.2 Me                                                                              Et     Et                                      4-OCF.sub.3                                                                              5-Br     CO.sub.2 Me                                                                              Et     Et                                      4-CF.sub.3 4-F      CO.sub.2 Me                                                                              Et     Et                                      4-Cl       4-F      CO.sub.2 Me                                                                              Et     Et                                      4-Br       4-F      CO.sub.2 Me                                                                              Et     Et                                      4-OCF.sub.3                                                                              4-F      CO.sub.2 Me                                                                              Et     Et                                      4-CF.sub.3 5-CF.sub.3                                                                             CO.sub.2 Me                                                                              Et     Et                                      4-CF.sub.3 5-F      CO.sub.2 Me                                                                              Et     Et                                      4-CF.sub.3 5-Cl     Ph         Et     Et                                      4-CF.sub.3 5-Cl     4-ClPh     Et     Et                                      4-CF.sub.3 5-Cl     CO.sub.2 Et                                                                              Et     Et                                      4-CF.sub.3 5-Cl     Ph         Ph     Ph                                      4-CF.sub.3 5-Cl     4-ClPh     Ph     Ph                                      4-CF.sub.3 5-Cl     CO.sub.2 Et                                                                              Ph     Ph                                      ______________________________________                                    

                                      TABLE 6                                     __________________________________________________________________________     ##STR18##                                                                    R.sub.1         R.sub.2   B          R.sub.8    R.sub.12                      __________________________________________________________________________    4-CF.sub.3      H         CO.sub.2 Me                                                                              nBu        nBu                           4-Cl            H         CO.sub.2 Me                                                                              nBu        nBu                           4-Br            H         CO.sub.2 Me                                                                              nBu        nBu                           4-OCF.sub.3     H         CO.sub.2 Me                                                                              nBu        nBu                           4-CF.sub.3      5-Cl      CO.sub.2 Me                                                                              nBu        nBu                           4-Cl            5-Cl      CO.sub.2 Me                                                                              nBu        nBu                           4-Br            5-Cl      CO.sub.2 Me                                                                              nBu        nBu                           4-OCF.sub.3     5-Cl      CO.sub.2 Me                                                                              nBu        nBu                           4-CF.sub.3      5-Br      CO.sub.2 Me                                                                              nBu        nBu                           4-Cl            5-Br      CO.sub.2 Me                                                                              nBu        nBu                           4-Br            5-Br      CO.sub.2 Me                                                                              nBu        nBu                           4-OCF.sub.3     5-Br      CO.sub.2 Me                                                                              nBu        nBu                           4-CF.sub.3      4-F       CO.sub.2 Me                                                                              nBu        nBu                           4-Cl            4-F       CO.sub.2 Me                                                                              nBu        nBu                           4-Br            4-F       CO.sub.2 Me                                                                              nBu        nBu                           4-OCF.sub.3     4-F       CO.sub.2 Me                                                                              nBu        nBu                           4-CF.sub.3      5-CF.sub.3                                                                              CO.sub.2 Me                                                                              nBu        nBu                           4-CF.sub.3      5-F       CO.sub.2 Me                                                                              nBu        nBu                           4-CF.sub.3      5-Cl      Ph         nBu        nBu                           4-CF.sub.3      5-Cl      4-ClPh     nBu        nBu                           4-CF.sub.3      5-Cl      CO.sub.2 Et                                                                              nBu        nBu                           4-CF.sub.3      H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Cl            H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Br            H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-OCF.sub.3     H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Cl            5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Br            5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-OCF.sub.3     5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Cl            5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Br            5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-OCF.sub.3     5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Cl            4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-Br            4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-OCF.sub.3     4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      5-CF.sub.3                                                                              CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      5-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      5-Cl      Ph         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      5-Cl      4-ClPh     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      5-Cl      CO.sub.2 Et                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                           CH.sub.2                                 4-CF.sub.3      H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                          9                                        4-Cl            H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                          2                                        4-Br            H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                          1                                        4-OCF.sub.3     H         CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                          .                                        4-CF.sub.3      5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-Cl            5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-Br            5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-OCF.sub.3     5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-Cl            5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-Br            5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-OCF.sub.3     5-Br      CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-Cl            4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-Br            4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-OCF.sub.3     4-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      5-CF.sub.3                                                                              CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      5-F       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      5-Cl      Ph         CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      5-Cl      4-ClPh     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      5-Cl      CO.sub.2 Et                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     4-CF.sub.3      H         CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Cl            H         CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Br            H         CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-OCF.sub.3     H         CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub. 3     5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Cl            5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Br            5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-OCF.sub.3     5-Cl      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      5-Br      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Cl            5-Br      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Br            5-Br      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-OCF.sub.3     5-Br      CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      4-F       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Cl            4-F       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-Br            4-F       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-OCF.sub.3     4-F       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      5-CF.sub.3                                                                              CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      5-F       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      5-Cl      Ph         CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      5-Cl      4-ClPh     CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      5-Cl      CO.sub.2 Et                                                                              CH.sub.2 CHMeOCHMeCH.sub.2               4-CF.sub.3      H         CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Cl            H         CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Br            H         CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-OCF.sub.3     H         CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      5-Cl      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Cl            5-Cl      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Br            5-Cl      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-OCF.sub.3     5-Cl      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      5-Br      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Cl            5-Br      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Br            5-Br      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-OCF.sub.3     5-Br      CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      4-F       CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Cl            4-F       CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-Br            4-F       CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-OCF.sub.3     4-F       CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      5-CF.sub.3                                                                              CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      5-F       CO.sub.2 Me                                                                              Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      5-Cl      Ph         Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      5-Cl      4-ClPh     Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      5-Cl      CO.sub.2 Et                                                                              Et         cyclo-C.sub.6 H.sub.11        4-CF.sub.3      H         CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Cl            H         CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Br            H         CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-OCF.sub.3     H         CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      5-Cl      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Cl            5-Cl      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Br            5-Cl      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-OCF.sub.3     5-Cl      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      5-Br      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Cl            5-Br      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Br            5-Br      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-OCF.sub.3     5-Br      CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      4-F       CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Cl            4-F       CO.sub. 2 Me                                                                             iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-Br            4-F       CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-OCF.sub.3     4-F       CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      5-CF.sub.3                                                                              CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      5-F       CO.sub.2 Me                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      5-Cl      Ph         iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      5-Cl      4-ClPh     iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   4-CF.sub.3      5-Cl      CO.sub.2 Et                                                                              iPr        CH.sub.2 CH.sub.2                                                             CO.sub.2 Et                   __________________________________________________________________________

                  TABLE 7                                                         ______________________________________                                         ##STR19##                                                                    R.sub.1     R.sub.2   B           R.sub.10                                    ______________________________________                                        4-CF.sub.3  H         CO.sub.2 Me tBu                                         4-Cl        H         CO.sub.2 Me tBu                                         4-Br        H         CO.sub.2 Me tBu                                         4-OCF.sub.3 H         CO.sub.2 Me tBu                                         4-CF.sub.3  5-Cl      CO.sub.2 Me tBu                                         4-Cl        5-Cl      CO.sub.2 Me tBu                                         4-Br        5-Cl      CO.sub.2 Me tBu                                         4-OCF.sub.3 5-Cl      CO.sub.2 Me tBu                                         4-CF.sub.3  5-Br      CO.sub.2 Me tBu                                         4-Cl        5-Br      CO.sub.2 Me tBu                                         4-Br        5-Br      CO.sub.2 Me tBu                                         4-OCF.sub.3 5-Br      CO.sub.2 Me tBu                                         4-CF.sub.3  4-F       CO.sub.2 Me tBu                                         4-Cl        4-F       CO.sub.2 Me tBu                                         4-Br        4-F       CO.sub.2 Me tBu                                         4-OCF.sub.3 4-F       CO.sub.2 Me tBu                                         4-CF.sub.3  5-CF.sub.3                                                                              CO.sub.2 Me tBu                                         4-CF.sub.3  5-F       CO.sub.2 Me tBu                                         4-CF.sub.3  5-Cl      Ph          tBu                                         4-CF.sub.3  5-Cl      4-ClPh      tBu                                         4-CF.sub.3  5-Cl      CO.sub.2 Et tBu                                         4-CF.sub.3  H         CO.sub.2 Me Ph                                          4-Cl        H         CO.sub.2 Me Ph                                          4-Br        H         CO.sub.2 Me Ph                                          4-OCF.sub.3 H         CO.sub.2 Me Ph                                          4-CF.sub.3  5-Cl      CO.sub.2 Me Ph                                          4-Cl        5-Cl      CO.sub.2 Me Ph                                          4-Br        5-Cl      CO.sub.2 Me Ph                                          4-OCF.sub.3 5-Cl      CO.sub.2 Me Ph                                          4-CF.sub.3  5-Br      CO.sub.2 Me Ph                                          4-Cl        5-Br      CO.sub.2 Me Ph                                          4-Br        5-Br      CO.sub.2 Me Ph                                          4-OCF.sub.3 5-Br      CO.sub.2 Me Ph                                          4-CF.sub.3  4-F       CO.sub.2 Me Ph                                          4-Cl        4-F       CO.sub.2 Me Ph                                          4-Br        4-F       CO.sub.2 Me Ph                                          4-OCF.sub.3 4-F       CO.sub.2 Me Ph                                          4-CF.sub.3  5-CF.sub.3                                                                              CO.sub.2 Me Ph                                          4-CF.sub.3  5-F       CO.sub.2 Me Ph                                          4-CF.sub.3  5-Cl      Ph          Ph                                          4-CF.sub.3  5-Cl      4-ClPh      Ph                                          4-CF.sub.3  5-Cl      CO.sub.2 Et Ph                                          4-CF.sub.3  H         CO.sub.2 Me 4-ClPh                                      4-Cl        H         CO.sub.2 Me 4-ClPh                                      4-Br        H         CO.sub.2 Me 4-ClPh                                      4-OCF.sub.3 H         CO.sub.2 Me 4-ClPh                                      4-CF.sub.3  5-Cl      CO.sub.2 Me 4-Cl Ph                                     4-Cl        5-Cl      CO.sub.2 Me 4-ClPh                                      4-Br        5-Cl      CO.sub.2 Me 4-ClPh                                      4-OCF.sub.3 5-Cl      CO.sub.2 Me 4-ClPh                                      4-CF.sub.3  5-Br      CO.sub.2 Me 4-ClPh                                      4-Cl        5-Br      CO.sub.2 Me 4-ClPh                                      4-Br        5-Br      CO.sub.2 Me 4-ClPh                                      4-OCF.sub.3 5-Br      CO.sub.2 Me 4-ClPh                                      4-CF.sub.3  4-F       CO.sub.2 Me 4-ClPh                                      4-Cl        4-F       CO.sub.2 Me 4-ClPh                                      4-Br        4-F       CO.sub.2 Me 4-ClPh                                      4-OCF.sub.3 4-F       CO.sub.2 Me 4-ClPh                                      4-CF.sub.3  5-CF.sub.3                                                                              CO.sub.2 Me 4-ClPh                                      4-CF.sub.3  5-F       CO.sub.2 Me 4-ClPh                                      ______________________________________                                    

                                      TABLE 8                                     __________________________________________________________________________     ##STR20##                                                                    R.sub.1       R.sub.2   B     V          R.sub.8  R.sub.9                     __________________________________________________________________________    4-CF.sub.3    5-Br      H     O          Me       OEt                         4-Cl          5-Br      H     O          Me       OEt                         4-Br          5-Br      H     O          Me       OEt                         4-OCF.sub.3   5-Br      H     O          Me       OEt                         4-CF.sub.3    5-Cl      H     O          Me       OEt                         4-Cl          5-Cl      H     O          Me       OEt                         4-Br          5-Cl      H     O          Me       OEt                         4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       OEt                         4-CF.sub.3    4-F       H     O          Me       OEt                         4-CF.sub.3    H         H     O          Me       OEt                         4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       OEt                         4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       OEt                         4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       OEt                         4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       OEt                         4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       OEt                         4-CF.sub.3    5-Cl      H     S          Me       OEt                         4-Cl          5-Cl      H     S          Me       OEt                         4-Br          5-Cl      H     S          Me       OEt                         4-CF.sub.3    5-Br      H     S          Me       OEt                         4-CF.sub.3    5-F       H     S          Me       OEt                         4-CF.sub.3    4-Cl      H     S          Me       OEt                         4-CF.sub.3    4-F       H     S          Me       OEt                         4-CF.sub.3    H         H     S          Me       OEt                         4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       OEt                         4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       OEt                         4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       OEt                         4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       OEt                         4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       OEt                         4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       OEt                         4-CF.sub.3    5-Br      H     O          Me       O-n-Bu                      4-Cl          5-Br      H     O          Me       O-n-Bu                      4-Br          5-Br      H     O          Me       O-n-Bu                      4-OCF.sub.3   5-Br      H     O          Me       O-n-Bu                      4-CF.sub.3    5-Cl      H     O          Me       O-n-Bu                      4-Cl          5-Cl      H     O          Me       O-n-Bu                      4-Br          5-Cl      H     O          Me       O-n-Bu                      4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       O-n-Bu                      4-CF.sub.3    4-F       H     O          Me       O-n-Bu                      4-CF.sub.3    H         H     O          Me       O-n-Bu                      4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       O-n-Bu                      4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       O-n-Bu                      4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       O-n-Bu                      4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       O-n-Bu                      4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       O-n-Bu                      4-CF.sub.3    5-Cl      H     S          Me       O-n-Bu                      4-Cl          5-Cl      H     S          Me       O-n-Bu                      4-Br          5-Cl      H     S          Me       O-n-Bu                      4-CF.sub.3    5-Br      H     S          Me       O-n-Bu                      4-CF.sub.3    5-F       H     S          Me       O-n-Bu                      4-CF.sub.3    4-Cl      H     S          Me       O-n-Bu                      4-CF.sub.3    4-F       H     S          Me       O-n-Bu                      4-CF.sub.3    H         H     S          Me       O-n-Bu                      4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       O-n-Bu                      4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       O-n-Bu                      4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       O-n-Bu                      4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       O-n-Bu                      4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       O-n-Bu                      4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       O-n-Bu                      4-CF.sub.3    5-Br      H     O          Me       O-n-hexyl                   4-Cl          5-Br      H     O          Me       O-n-hexyl                   4-Br          5-Br      H     O          Me       O-n-hexyl                   4-OCF.sub.3   5-Br      H     O          Me       O-n-hexyl                   4-CF.sub.3    5-Cl      H     O          Me       O-n-hexyl                   4-Cl          5-Cl      H     O          Me       O-n-hexyl                   4-Br          5-Cl      H     O          Me       O-n-hexyl                   4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       O-n-hexyl                   4-CF.sub.3    4-F       H     O          Me       O-n-hexyl                   4-CF.sub.3    H         H     O          Me       O-n-hexyl                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       O-n-hexyl                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       O-n-hexyl                   4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       O-n-hexyl                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       O-n-hexyl                   4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       O-n-hexyl                   4-CF.sub.3    5-Cl      H     S          Me       O-n-hexyl                   4-Cl          5-Cl      H     S          Me       O-n-hexyl                   4-Br          5-Cl      H     S          Me       O-n-hexyl                   4-CF.sub.3    5-Br      H     S          Me       O-n-hexyl                   4-CF.sub.3    5-F       H     S          Me       O-n-hexyl                   4-CF.sub.3    4-Cl      H     S          Me       O-n-hexyl                   4-CF.sub.3    4-F       H     S          Me       O-n-hexyl                   4-CF.sub.3    H         H     S          Me       O-n-hexyl                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       O-n-hexyl                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       O-n-hexyl                   4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       O-n-hexyl                   4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       O-n-hexyl                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       O-n-hexyl                   4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       O-n-hexyl                   4-CF.sub.3    5-Br      H     O          Me       O-n-octyl                   4-Cl          5-Br      H     O          Me       O-n-octyl                   4-Br          5-Br      H     O          Me       O-n-octyl                   4-OCF.sub.3   5-Br      H     O          Me       O-n-octyl                   4-CF.sub. 3   5-Cl      H     O          Me       O-n-octyl                   4-Cl          5-Cl      H     O          Me       O-n-octyl                   4-Br          5-Cl      H     O          Me       O-n-octyl                   4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       O-n-octyl                   4-CF.sub.3    4-F       H     O          Me       O-n-octyl                   4-CF.sub.3    H         H     O          Me       O-n-octyl                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       O-n-octyl                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       O-n-octyl                   4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       O-n-octyl                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       O-n-octyl                   4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       O-n-octyl                   4-CF.sub.3    5-Cl      H     S          Me       O-n-octyl                   4-Cl          5-Cl      H     S          Me       O-n-octyl                   4-Br          5-Cl      H     S          Me       O-n-octyl                   4-CF.sub.3    5-Br      H     S          Me       O-n-octyl                   4-CF.sub.3    5-F       H     S          Me       O-n-octyl                   4-CF.sub.3    4-Cl      H     S          Me       O-n-octyl                   4-CF.sub.3    4-F       H     S          Me       O-n-octyl                   4-CF.sub.3    H         H     S          Me       O-n-octyl                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       O-n-octyl                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       O-n-octyl                   4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       O-n-octyl                   4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       O-n-octyl                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       O-n-octyl                   4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       O-n-octyl                   4-CF.sub.3    5-Br      H     O          Me       O-n-decyl                   4-Cl          5-Br      H     O          Me       O-n-decyl                   4-Br          5-Br      H     O          Me       O-n-decyl                   4-OCF.sub.3   5-Br      H     O          Me       O-n-decyl                   4-CF.sub.3    5-Cl      H     O          Me       O-n-decyl                   4-Cl          5-Cl      H     O          Me       O-n-decyl                   4-Br          5-Cl      H     O          Me       O-n-decyl                   4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       O-n-decyl                   4-CF.sub.3    4-F       H     O          Me       O-n-decyl                   4-CF.sub.3    H         H     O          Me       O-n-decyl                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       O-n-decyl                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       O-n-decyl                   4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       O-n-decyl                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       O-n-decyl                   4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       O-n-decyl                   4-CF.sub.3    5-Cl      H     S          Me       O-n-decyl                   4-Cl          5-Cl      H     S          Me       O-n-decyl                   4-Br          5-Cl      H     S          Me       O-n-decyl                   4-CF.sub.3    5-Br      H     S          Me       O-n-decyl                   4-CF.sub.3    5-F       H     S          Me       O-n-decyl                   4-CF.sub.3    4-Cl      H     S          Me       O-n-decyl                   4-CF.sub.3    4-F       H     S          Me       O-n-decyl                   4-CF.sub.3    H         H     S          Me       O-n-decyl                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       O-n-decyl                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       O-n-decyl                   4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       O-n-decyl                   4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       O-n-decyl                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       O-n-decyl                   4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       O-n-decyl                   4-CF.sub.3    5-Br      H     O          Me       O-n-dodecyl                 4-Cl          5-Br      H     O          Me       O-n-dedecyl                 4-Br          5-Br      H     O          Me       O-n-dodecyl                 4-OCF.sub.3   5-Br      H     O          Me       O-n-dodecyl                 4-CF.sub.3    5-Cl      H     O          Me       O-n-dodecyl                 4-Cl          5-Cl      H     O          Me       O-n-dodecyl                 4-Br          5-Cl      H     O          Me       O-n-dodecyl                 4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       O-n-dodecyl                 4-CF.sub.3    4-F       H     O          Me       O-n-dodecyl                 4-CF.sub.3    H         H     O          Me       O-n-dodecyl                 4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       O-n-dodecyl                 4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       O-n-dodecyl                 4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       O-n-dodecyl                 4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       O-n-dodecyl                 4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       O-n-dodecyl                 4-CF.sub.3    5-Cl      H     S          Me       O-n-dodecyl                 4-Cl          5-Cl      H     S          Me       O-n-dodecyl                 4-Br          5-Cl      H     S          Me       O-n-dodecyl                 4-CF.sub.3    5-Br      H     S          Me       O-n-dodecyl                 4-CF.sub.3    5-F       H     S          Me       O-n-dodecyl                 4-CF.sub.3    4-Cl      H     S          Me       O-n-dodecyl                 4-CF.sub.3    4-F       H     S          Me       O-n-dodecyl                 4-CF.sub.3    H         H     S          Me       O-n-dodecyl                 4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       O-n-dodecyl                 4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       O-n-dodecyl                 4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       O-n-dodecyl                 4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       O-n-dodecyl                 4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       O-n-dodecyl                 4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       O-n-dodecyl                 4-CF.sub.3    5-Br      H     O          Me       O-sec-Bu                    4-Cl          5-Br      H     O          Me       O-sec-Bu                    4-Br          5-Br      H     O          Me       O-sec-Bu                    4-OCF.sub.3   5-Br      H     O          Me       O-sec-Bu                    4-CF.sub.3    5-Cl      H     O          Me       O-sec-Bu                    4-Cl          5-Cl      H     O          Me       O-sec-Bu                    4-Br          5-Cl      H     O          Me       O-sec-Bu                    4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       O-sec-Bu                    4-CF.sub.3    4-F       H     O          Me       O-sec-Bu                    4-CF.sub.3    H         H     O          Me       O-sec-Bu                    4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       O-sec-Bu                    4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       O-sec-Bu                    4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       O-sec-Bu                    4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       O-sec-Bu                    4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       O-sec-Bu                    4-CF.sub.3    5-Cl      H     S          Me       O-sec-Bu                    4-Cl          5-Cl      H     S          Me       O-sec-Bu                    4-Br          5-Cl      H     S          Me       O-sec-Bu                    4-CF.sub.3    5-Br      H     S          Me       O-sec-Bu                    4-CF.sub.3    5-F       H     S          Me       O-sec-Bu                    4-CF.sub.3    4-Cl      H     S          Me       O-sec-Bu                    4-CF.sub.3    4-F       H     S          Me       O-sec-Bu                    4-CF.sub.3    H         H     S          Me       O-sec-Bu                    4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       O-sec-Bu                    4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       O-sec-Bu                    4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       O-sec-Bu                    4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       O-sec-Bu                    4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       O-sec-Bu                    4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       O-sec-Bu                    4-CF.sub.3    5-Br      H     O          Me       O-iPr                       4-Cl          5-Br      H     O          Me       O-iPr                       4-Br          5-Br      H     O          Me       O-iPr                       4-OCF.sub.3   5-Br      H     O          Me       O-iPr                       4-CF.sub.3    5-Cl      H     O          Me       O-iPr                       4-Cl          5-Cl      H     O          Me       O-iPr                       4-Br          5-Cl      H     O          Me       O-iPr                       4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       O-iPr                       4-CF.sub.3    4-F       H     O          Me       O-iPr                       4-CF.sub.3    H         H     O          Me       O-iPr                       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       O-iPr                       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       O-iPr                       4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       O-iPr                       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       O-iPr                       4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       O-iPr                       4-CF.sub.3    5-Cl      H     S          Me       O-iPr                       4-Cl          5-Cl      H     S          Me       O-iPr                       4-Br          5-Cl      H     S          Me       O-iPr                       4-CF.sub.3    5-Br      H     S          Me       O-iPr                       4-CF.sub.3    5-F       H     S          Me       O-iPr                       4-CF.sub.3    4-Cl      H     S          Me       O-iPr                       4-CF.sub.3    4-F       H     S          Me       O-iPr                       4-CF.sub.3    H         H     S          Me       O-iPr                       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       O-iPr                       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       O-iPr                       4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       O-iPr                       4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       O-iPr                       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       O-iPr                       4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       O-iPr                       4-CF.sub.3    5-Br      H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-Cl          5-Br      H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-Br          5-Br      H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-OCF.sub.3   5-Br      H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Cl      H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-Cl          5-Cl      H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-Br          5-Cl      H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    4-F       H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    H         H     O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Cl      H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-Cl          5-Cl      H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-Br          5-Cl      H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Br      H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-F       H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    4-Cl      H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    4-F       H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    H         H     S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub. 3   H         CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CH.sub.2 OEt      4-CF.sub.3    5-Br      H     O          Me       OCH.sub.2 CCl.sub.3         4-Cl          5-Br      H     O          Me       OCH.sub.2 CCl.sub.3         4-Br          5-Br      H     O          Me       OCH.sub.2 CCl.sub.3         4-OCF.sub.3   5-Br      H     O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Cl      H     O          Me       OCH.sub.2 CCl.sub.3         4-Cl          5-Cl      H     O          Me       OCH.sub.2 CCl.sub.3         4-Br          5-Cl      H     O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    4-F       H     O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    H         H     O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Cl      H     S          Me       OCH.sub.2 CCl.sub.3         4-Cl          5-Cl      H     S          Me       OCH.sub.2 CCl.sub.3         4-Br          5-Cl      H     S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Br      H     S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-F       H     S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    4-Cl      H     S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    4-F       H     S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    H         H     S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CCl.sub.3         4-CF.sub.3    5-Br      H     O          Me       OCH.sub.2 CF.sub.3          4-Cl          5-Br      H     O          Me       OCH.sub.2 CF.sub.3          4-Br          5-Br      H     O          Me       OCH.sub.2 CF.sub.3          4-OCF.sub.3   5-Br      H     O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Cl      H     O          Me       OCH.sub.2 CF.sub.3          4-Cl          5-Cl      H     O          Me       OCH.sub.2 CF.sub.3          4-Br          5-Cl      H     O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    4-F       H     O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    H         H     O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Cl      H     S          Me       OCH.sub.2 CF.sub.3          4-Cl          5-Cl      H     S          Me       OCH.sub.2 CF.sub.3          4-Br          5-Cl      H     S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Br      H     S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-F       H     S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    4-Cl      H     S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    4-F       H     S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    H         H     S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub. 2 CF.sub.3         4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CF.sub.3          4-CF.sub.3    5-Br      H     O          Me       OCH.sub.2 CO.sub.2 Et       4-Cl          5-Br      H     O          Me       OCH.sub.2 CO.sub.2 Et       4-Br          5-Br      H     O          Me       OCH.sub.2 CO.sub.2 Et       4-OCF.sub.3   5-Br      H     O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Cl      H     O          Me       OCH.sub.2 CO.sub.2 Et       4-Cl          5-Cl      H     O          Me       OCH.sub.2 CO.sub.2 Et       4-Br          5-Cl      H     O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    4-F       H     O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    H         H     O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Cl      H     S          Me       OCH.sub.2 CO.sub.2 Et       4-Cl          5-Cl      H     S          Me       OCH.sub.2 CO.sub.2 Et       4-Br          5-Cl      H     S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Br      H     S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-F       H     S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    4-Cl      H     S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    4-F       H     S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    H         H     S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Br      H     O          Me       F                           4-Cl          5-Br      H     O          Me       F                           4-Br          5-Br      H     O          Me       F                           4-OCF.sub.3   5-Br      H     O          Me       F                           4-CF.sub.3    5-Cl      H     O          Me       F                           4-Cl          5-Cl      H     O          Me       F                           4-Br          5-Cl      H     O          Me       F                           4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       F                           4-CF.sub.3    4-F       H     O          Me       F                           4-CF.sub.3    H         H     O          Me       F                           4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       F                           4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       F                           4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       F                           4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       F                           4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       F                           4-CF.sub.3    5-Cl      H     S          Me       F                           4-Cl          5-Cl      H     S          Me       F                           4-Br          5-Cl      H     S          Me       F                           4-CF.sub.3    5-Br      H     S          Me       F                           4-CF.sub.3    5-F       H     S          Me       F                           4-CF.sub.3    4-Cl      H     S          Me       F                           4-CF.sub.3    4-F       H     S          Me       F                           4-CF.sub.3    H         H     S          Me       F                           4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       F                           4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       F                           4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       F                           4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       F                           4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       F                           4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       F                           4-CF.sub.3    5-Br      H     O          Me       NMe.sub.2                   4-Cl          5-Br      H     O          Me       NMe.sub.2                   4-Br          5-Br      H     O          Me       NMe.sub.2                   4-OCF.sub.3   5-Br      H     O          Me       NMe.sub.2                   4-CF.sub.3    5-Cl      H     O          Me       NMe.sub.2                   4-Cl          5-Cl      H     O          Me       NMe.sub.2                   4-Br          5-Cl      H     O          Me       NMe.sub.2                   4-CF.sub.3    5-CF.sub.3                                                                              H     O          Me       NMe.sub.2                   4-CF.sub.3    4-F       H     O          Me       NMe.sub.2                   4-CF.sub.3    H         H     O          Me       NMe.sub.2                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Me       NMe.sub.2                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Me       NMe.sub.2                   4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Me       NMe.sub.2                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Me       NMe.sub.2                   4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Me       NMe.sub.2                   4-CF.sub.3    5-Cl      H     S          Me       NMe.sub.2                   4-Cl          5-Cl      H     S          Me       NMe.sub.2                   4-Br          5-Cl      H     S          Me       NMe.sub.2                   4-CF.sub.3    5-Br      H     S          Me       NMe.sub.2                   4-CF.sub.3    5-F       H     S          Me       NMe.sub.2                   4-CF.sub.3    4-Cl      H     S          Me       NMe.sub.2                   4-CF.sub.3    4-F       H     S          Me       NMe.sub.2                   4-CF.sub.3    H         H     S          Me       NMe.sub.2                   4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Me       NMe.sub.2                   4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Me       NMe.sub.2                   4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Me       NMe.sub.2                   4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Me       NMe.sub.2                   4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Me       NMe.sub.2                   4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Me       NMe.sub.2                   4-CF.sub.3    5-Br      H     O          Et       O-iPr                       4-Cl          5-Br      H     O          Et       O-iPr                       4-Br          5-Br      H     O          Et       O-iPr                       4-OCF.sub.3   5-Br      H     O          Et       O-iPr                       4-CF.sub.3    5-Cl      H     O          Et       O-iPr                       4-Cl          5-Cl      H     O          Et       O-iPr                       4-Br          5-Cl      H     O          Et       O-iPr                       4-CF.sub.3    5-CF.sub.3                                                                              H     O          Et       O-iPr                       4-CF.sub.3    4-F       H     O          Et       O-iPr                       4-CF.sub.3    H         H     O          Et       O-iPr                       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          Et       O-iPr                       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          Et       O-iPr                       4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          Et       O-iPr                       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          Et       O-iPr                       4-CF.sub.3    H         CO.sub.2 Me                                                                         O          Et       O-iPr                       4-CF.sub.3    5-Cl      H     S          Et       O-iPr                       4-Cl          5-Cl      H     S          Et       O-iPr                       4-Br          5-Cl      H     S          Et       O-iPr                       4-CF.sub.3    5-Br      H     S          Et       O-iPr                       4-CF.sub.3    5-F       H     S          Et       O-iPr                       4-CF.sub.3    4-Cl      H     S          Et       O-iPr                       4-CF.sub.3    4-F       H     S          Et       O-iPr                       4-CF.sub.3    H         H     S          Et       O-iPr                       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          Et       O-iPr                       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          Et       O-iPr                       4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          Et       O-iPr                       4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          Et       O-iPr                       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          Et       O-iPr                       4-CF.sub.3    H         CO.sub.2 Me                                                                         S          Et       O-iPr                       4-CF.sub.3    5-Br      H     O          iPr      OEt                         4-Cl          5-Br      H     O          iPr      OEt                         4-Br          5-Br      H     O          iPr      OEt                         4-OCF.sub.3   5-Br      H     O          iPr      OEt                         4-CF.sub.3    5-Cl      H     O          iPr      OEt                         4-Cl          5-Cl      H     O          iPr      OEt                         4-Br          5-Cl      H     O          iPr      OEt                         4-CF.sub.3    5-CF.sub.3                                                                              H     O          iPr      OEt                         4-CF.sub.3    4-F       H     O          iPr      OEt                         4-CF.sub.3    H         H     O          iPr      OEt                         4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          iPr      OEt                         4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          iPr      OEt                         4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          iPr      OEt                         4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          iPr      OEt                         4-CF.sub.3    H         CO.sub.2 Me                                                                         O          iPr      OEt                         4-CF.sub.3    5-Cl      H     S          iPr      OEt                         4-Cl          5-Cl      H     S          iPr      OEt                         4-Br          5-Cl      H     S          iPr      OEt                         4-CF.sub.3    5-Br      H     S          iPr      OEt                         4-CF.sub.3    5-F       H     S          iPr      OEt                         4-CF.sub.3    4-Cl      H     S          iPr      OEt                         4-CF.sub.3    4-F       H     S          iPr      OEt                         4-CF.sub.3    H         H     S          iPr      OEt                         4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          iPr      OEt                         4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          iPr      OEt                         4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          iPr      OEt                         4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          iPr      OEt                         4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          iPr      OEt                         4-CF.sub.3    H         CO.sub.2 Me                                                                         S          iPr      OEt                         4-CF.sub.3    5-Br      H     O          iPr      O-nBu                       4-Cl          5-Br      H     O          iPr      O-nBu                       4-Br          5-Br      H     O          iPr      O-nBu                       4-OCF.sub.3   5-Br      H     O          iPr      O-nBu                       4-CF.sub.3    5-Cl      H     O          iPr      O-nBu                       4-Cl          5-Cl      H     O          iPr      O-nBu                       4-Br          5-Cl      H     O          iPr      O-nBu                       4-CF.sub.3    5-CF.sub.3                                                                              H     O          iPr      O-nBu                       4-CF.sub.3    4-F       H     O          iPr      O-nBu                       4-CF.sub.3    H         H     O          iPr      O-nBu                       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          iPr      O-nBu                       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          iPr      O-nBu                       4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          iPr      O-nBu                       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          iPr      O-nBu                       4-CF.sub.3    H         CO.sub.2 Me                                                                         O          iPr      O-nBu                       4-CF.sub.3    5-Cl      H     S          iPr      O-nBu                       4-Cl          5-Cl      H     S          iPr      O-nBu                       4-Br          5-Cl      H     S          iPr      O-nBu                       4-CF.sub.3    5-Br      H     S          iPr      O-nBu                       4-CF.sub.3    5-F       H     S          iPr      O-nBu                       4-CF.sub.3    4-Cl      H     S          iPr      O-nBu                       4-CF.sub.3    4-F       H     S          iPr      O-nBu                       4-CF.sub.3    H         H     S          iPr      O-nBu                       4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         S          iPr      O-nBu                       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         S          iPr      O-nBu                       4-CF.sub.3    5-F       CO.sub.2 Me                                                                         S          iPr      O-nBu                       4-CF.sub.3    4-Cl      CO.sub.2 Me                                                                         S          iPr      O-nBu                       4-CF.sub.3    4-F       CO.sub.2 Me                                                                         S          iPr      O-nBu                       4-CF.sub.3    H         CO.sub.2 Me                                                                         S          iPr      O-nBu                       4-CF.sub.3    5-Br      H     O          iPr      OCH.sub.2 CF.sub.3          4-Cl          5-Br      H     O          iPr      OCH.sub.2 CO.sub.2 Me       4-Br          5-Br      H     O          iPr      NMe.sub.2                   4-OCF.sub.2   5-Br      H     O          iPr      NEt.sub.2                   4-CF.sub.3    5-Cl      H     O          iPr      piperidino                  4-Cl          5-Cl      H     O          iPr      Et                          4-Br          5-Cl      H     O          iPr      4-Br-Ph                     4-CF.sub.3    5-CF.sub.3                                                                              H     O          CH.sub.2 Ph                                                                            OEt                         4-CF.sub.3    4-F       H     O          CH.sub.2 Ph                                                                            O-n-octyl                   4-CF.sub.3    H         H     O          CH.sub.2 Ph                                                                            OCH.sub.2 CO.sub.2 Et       4-CF.sub.3    5-Br      CO.sub.2 Me                                                                         O          CH.sub.2 Ph                                                                            F                           4-CF.sub.3    5-Cl      CO.sub.2 Me                                                                         O          CH.sub.2 Ph                                                                            NEt.sub. 2                  4-CF.sub.3    5-CF.sub.3                                                                              CO.sub.2 Me                                                                         O          CH.sub.2 Ph                                                                            morpholino                  4-CF.sub.3    4-F       CO.sub.2 Me                                                                         O          CH.sub.2 Ph                                                                            4-Cl-Ph                     4-CF.sub.3    H         CO.sub.2 Me                                                                         O          CH.sub.2 Ph                                                                            Et                          4-CF.sub.3    5-Cl      H     S          CH.sub.2 Ph                                                                            Ph                          __________________________________________________________________________

                  TABLE 9                                                         ______________________________________                                         ##STR21##                                                                    R.sub.1                                                                              R.sub.2 B        V    R.sub.8                                                                            R.sub.9                                     ______________________________________                                        4-CF.sub.3                                                                           5-Br    H        O    Me   NMe.sub.2                                   4-Cl   5-Br    H        O    Me   NMe.sub.2                                   4-Br   5-Br    H        O    Me   NMe.sub.2                                   4-OCF.sub.3                                                                          5-Br    H        O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    H        O    Me   NMe.sub.2                                   4-Cl   5-Cl    H        O    Me   NMe.sub.2                                   4-Br   5-Cl    H        O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-CF.sub.3                                                                            H        O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           4-F     H        O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           H       H        O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            O    Me   NMe.sub. 2                                  4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    H        S    Me   NMe.sub.2                                   4-Cl   5-Cl    H        S    Me   NMe.sub.2                                   4-Br   5-Cl    H        S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Br    H        S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-F     H        S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           4-Cl    H        S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           4-F     H        S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           H       H        S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-F     CO.sub.2 Me                                                                            S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           4-Cl    CO.sub.2 Me                                                                            S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            S    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Br    H        O    Me   NEt.sub.2                                   4-Cl   5-Br    H        O    Me   NEt.sub.2                                   4-Br   5-Br    H        O    Me   NEt.sub.2                                   4-OCF.sub.3                                                                          5-Br    H        O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Cl    H        O    Me   NEt.sub.2                                   4-Cl   5-Cl    H        O    Me   NEt.sub.2                                   4-Br   5-Cl    H        O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-CF.sub.3                                                                            H        O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           4-F     H        O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           H       H        O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            O    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Cl    H        S    Me   NEt.sub.2                                   4-Cl   5-Cl    H        S    Me   NEt.sub.2                                   4-Br   5-Cl    H        S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Br    H        S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-F     H        S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           4-Cl    H        S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           4-F     H        S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           H       H        S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-F     CO.sub.2 Me                                                                            S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           4-Cl    CO.sub.2 Me                                                                            S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            S    Me   NEt.sub.2                                   4-CF.sub.3                                                                           5-Br    H        O    Me   piperidino                                  4-Cl   5-Br    H        O    Me   sec-Bu                                      4-Br   5-Br    H        O    Me   n-hexyl                                     4-OCF.sub.3                                                                          5-Br    H        O    Me   Ph                                          4-CF.sub.3                                                                           5-Cl    H        O    Me   5-ClPh                                      4-Cl   5-Cl    H        O    Me   4-MePh                                      4-Br   5-Cl    H        O    Me   n-Bu                                        4-CF.sub.3                                                                           5-CF.sub.3                                                                            H        O    Et   NMe.sub.2                                   4-CF.sub.3                                                                           4-F     H        O    Et   NEt.sub.2                                   4-CF.sub.3                                                                           H       H        O    Et   morpholino                                  4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            O    Et   iPr                                         4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            O    Et   n-Bu                                        4-CF.sub.3                                                                           5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O    Et   Ph                                          4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            O    Et   4-MeOPh                                     4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            O    Me   NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    H        S    Me   NEt.sub.2                                   4-Cl   5-Cl    H        S    Me   morpholino                                  4-Br   5-Cl    H        S    Me   iPr                                         4-CF.sub.3                                                                           5-Br    H        S    Me   n-Bu                                        4-CF.sub.3                                                                           5-F     H        S    Me   Ph                                          4-CF.sub.3                                                                           4-Cl    H        S    Me   4-MeOPh                                     4-CF.sub.3                                                                           4-F     H        S    Et   piperidino                                  4-CF.sub.3                                                                           H       H        S    Et   sec-Bu                                      4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            S    Et   n-hexyl                                     4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            S    Et   Ph                                          4-CF.sub.3                                                                           5-F     CO.sub.2 Me                                                                            S    Et   4-ClPh                                      4-CF.sub.3                                                                           4-Cl    CO.sub.2 Me                                                                            S    Et   4-MePh                                      4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            S    Et   n-Bu                                        4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            S    Et   2,6-di-Me-morpholino                        4-CF.sub.3                                                                           5-Br    H        O    iPr  NMe.sub.2                                   4-Cl   5-Br    H        O    iPr  NMe.sub.2                                   4-Br   5-Br    H        O    iPr  NMe.sub.2                                   4-OCF.sub.3                                                                          5-Br    H        O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    H        O    iPr  NMe.sub.2                                   4-Cl   5-Cl    H        O    iPr  NMe.sub.2                                   4-Br   5-Cl    H        O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-CF.sub.3                                                                            H        O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           4-F     H        O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           H       H        O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            O    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    H        S    iPr  NMe.sub.2                                   4-Cl   5-Cl    H        S    iPr  NMe.sub.2                                   4-Br   5-Cl    H        S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-Br    H        S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-F     H        S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           4-Cl    H        S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           4-F     H        S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           H       H        S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                            S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                            S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           5-F     CO.sub.2 Me                                                                            S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           4-Cl    CO.sub.2 Me                                                                            S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           4-F     CO.sub.2 Me                                                                            S    iPr  NMe.sub.2                                   4-CF.sub.3                                                                           H       CO.sub.2 Me                                                                            S    iPr  NMe.sub.2                                   ______________________________________                                    

                                      TABLE 10                                    __________________________________________________________________________     ##STR22##                                                                    R.sub.1     R.sub.2 B        V     R.sub.8                                                                              Y'    Y'R.sub.10                                                                            Y'R.sub.11            __________________________________________________________________________    4-CF.sub.3                                                                          5-Br H     O  tBu S  OEt   OEt                                          4-Cl  5-Br H     O  tBu S  OEt   OEt                                          4-Br  5-Br H     O  tBu S  OEt   OEt                                          4-OCF.sub.3                                                                         5-Br H     O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-Cl H     O  tBu S  OEt   OEt                                          4-Cl  5-Cl H     O  tBu S  OEt   OEt                                          4-Br  5-Cl H     O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-CF.sub.3                                                                         H     O  tBu S  OEt   OEt                                          4-CF.sub. 3                                                                         4-F  H     O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          H    H     O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-Br CO.sub.2 Me                                                                         O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-Cl CO.sub.2 Me                                                                         O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-CF.sub.3                                                                         CO.sub.2 Me                                                                         O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          4-F  CO.sub.2 Me                                                                         O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          H    CO.sub.2 Me                                                                         O  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-Cl H     S  tBu S  OEt   OEt                                          4-Cl  5-Cl H     S  tBu S  OEt   OEt                                          4-Br  5-Cl H     S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-Br H     S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-F  H     S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          4-Cl H     S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          4-F  H     S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          H    H     S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-Cl CO.sub.2 Me                                                                         S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-Br CO.sub.2 Me                                                                         S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          5-F  CO.sub.2 Me                                                                         S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          4-Cl CO.sub.2 Me                                                                         S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          4-F  CO.sub.2 Me                                                                         S  tBu S  OEt   OEt                                          4-CF.sub.3                                                                          H    CO.sub.2 Me                                                                         S  tBu S  OEt   OEt                                          4-CF.sub.3  5-Br    H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Br    H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Br    H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-OCF.sub.3 5-Br    H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Cl    H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Cl    H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       H        O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Cl    H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Cl    H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-F     H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-Cl    H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       H        S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     tBu    S      OCH.sub.2 C(Me).sub.2                                                        CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-Cl        5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-Br        5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-OCF.sub.3 5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Cl    H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-Cl        5-Cl    H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-Br        5-Cl    H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  4-F     H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  H       H        O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-Cl        5-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-Br        5-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Br    H        S     tBu    S      OCH.sub.2 CH.sub.2                                                           CH.sub.2 O                    4-CF.sub.3  5-F     H        S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  4-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  4-F     H        S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  H       H        S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  4-F     CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2                                                            CH.sub.2 O                    4-CF.sub.3  5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-Cl        5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-Br        5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-OCF.sub.3 5-Br    H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Cl    H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-Cl        5-Cl    H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-Br        5-Cl    H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-CF.sub.3                                                                            H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  4-F     H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  H       H        O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  H       CO.sub.2 Me                                                                            O     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-Cl        5-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-Br        5-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Br    H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-F     H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  4-Cl    H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  4-F     H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  H       H        S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  4-F     CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  H       CO.sub.2 Me                                                                            S     tBu    S     OCH.sub.2 CH.sub.2 O          4-CF.sub.3  5-Br    H        O     iPr    S     OEt     OEt                   4-Cl        5-Br    H        O     iPr    S     OEt     OEt                   4-Br        5-Br    H        O     iPr    S     OEt     OEt                   4-OCF.sub.3 5-Br    H        O     iPr    S     OEt     OEt                   4-CF.sub.3  5-Cl    H        O     iPr    S     OEt     OEt                   4-Cl        5-Cl    H        O     iPr    S     OEt     OEt                   4-Br        5-Cl    H        O     iPr    S     OEt     OEt                   4-CF.sub.3  5-CF.sub.3                                                                            H        O     iPr    S     OEt     OEt                   4-CF.sub.3  4-F     H        O     iPr    S     OEt     OEt                   4-CF.sub.3  H       H        O     iPr    S     OEt     OEt                   4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     iPr    S     OEt     OEt                   4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     iPr    S     OEt     OEt                   4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     iPr    S     OEt     OEt                   4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     iPr    S     OEt     OEt                   4-CF.sub.3  H       CO.sub.2 Me                                                                            O     iPr    S     OEt     OEt                   4-CF.sub.3  5-Cl    H        S     iPr    S     OEt     OEt                   4-Cl        5-Cl    H        S     iPr    S     OEt     OEt                   4-Br        5-Cl    H        S     iPr    S     OEt     OEt                   4-CF.sub.3  5-Br    H        S     iPr    S     OEt     OEt                   4-CF.sub.3  5-F     H        S     iPr    S     OEt     OEt                   4-CF.sub.3  4-Cl    H        S     iPr    S     OEt     OEt                   4-CF.sub.3  4-F     H        S     iPr    S     OEt     OEt                   4-CF.sub.3  H       H        S     iPr    S     OEt     OEt                   4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     iPr    S     OEt     OEt                   4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     iPr    S     OEt     OEt                   4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     iPr    S     OEt     OEt                   4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     iPr    S     OEt     OEt                   4-CF.sub.3  4-F     CO.sub.2 Me                                                                            S     iPr    S     OEt     OEt                   4-CF.sub.3  H       CO.sub.2 Me                                                                            S     iPr    S     OEt     OEt                   4-CF.sub.3  5-Br    H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Br    H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Br    H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-OCF.sub.3 5-Br    H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Cl    H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Cl    H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       H        O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            O     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    H        S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Cl    H        S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Cl    H        S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    H        S     iPr    S      OCH.sub.2 C(Me).sub.2                                                        CH.sub.2 O                    4-CF.sub.3  5-F     H        S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-Cl    H        S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     H        S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       H        S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     CO.sub.2 Me                                                                            S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            S     iPr    S     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    H        O     Me     S     OEt     OEt                   4-Cl        5-Br    H        O     Me     S     OEt     OEt                   4-Br        5-Br    H        O     Me     S     OEt     OEt                   4-OCF.sub.3 5-Br    H        O     Me     S     OEt     OEt                   4-CF.sub.3  5-Cl    H        O     Me     S     OEt     OEt                   4-Cl        5-Cl    H        O     Me     S     OEt     OEt                   4-Br        5-Cl    H        O     Me     S     OEt     OEt                   4-CF.sub.3  5-CF.sub.3                                                                            H        O     Me     S     OEt     OEt                   4-CF.sub.3  4-F     H        O     Me     S     OEt     OEt                   4-CF.sub.3  H       H        O     Me     S     OEt     OEt                   4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     Me     S     OEt     OEt                   4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     Me     S     OEt     OEt                   4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     Me     S     OEt     OEt                   4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     Me     S     OEt     OEt                   4-CF.sub.3  H       CO.sub.2 Me                                                                            O     Me     S     OEt     OEt                   4-CF.sub.3  5-Cl    H        S     Me     S     OEt     OEt                   4-Cl        5-Cl    H        S     Me     S     OEt     OEt                   4-Br        5-Cl    H        S     Me     S     OEt     OEt                   4-CF.sub.3  5-Br    H        S     Me     S     OEt     OEt                   4-CF.sub.3  5-F     H        S     Me     S     OEt     OEt                   4-CF.sub.3  4-Cl    H        S     Me     S     OEt     OEt                   4-CF.sub.3  4-F     H        S     Me     S     OEt     OEt                   4-CF.sub.3  H       H        S     Me     S     OEt     OEt                   4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     Me     S     OEt     OEt                   4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     Me     S     OEt     OEt                   4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     Me     S     OEt     OEt                   4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     Me     S     OEt     OEt                   4-CF.sub.3  4-F     CO.sub.2 Me                                                                            S     Me     S     OEt     OEt                   4-CF.sub.3  H       CO.sub.2 Me                                                                            S     Me     S     OEt     OEt                   4-CF.sub.3  5-Br    H        O     tBu    O     OEt     OEt                   4-Cl        5-Br    H        O     tBu    O     OEt     OEt                   4-Br        5-Br    H        O     tBu    O     OEt     OEt                   4-OCF.sub.3 5-Br    H        O     tBu    O     OEt     OEt                   4-CF.sub.3  5-Cl    H        O     tBu    O     OEt     OEt                   4-Cl        5-Cl    H        O     tBu    O     OEt     OEt                   4-Br        5-Cl    H        O     tBu    O     OEt     OEt                   4-CF.sub.3  5-CF.sub.3                                                                            H        O     tBu    O     OEt     OEt                   4-CF.sub.3  4-F     H        O     tBu    O     OEt     OEt                   4-CF.sub.3  H       H        O     tBu    O     OEt     OEt                   4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     tBu    O     OEt     OEt                   4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     tBu    O     OEt     OEt                   4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     tBu    O     OEt     OEt                   4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     tBu    O     OEt     OEt                   4-CF.sub. 3 H       CO.sub.2 Me                                                                            O     tBu    O     OEt     OEt                   4-CF.sub.3  5-Cl    H        S     tBu    O     OEt     OEt                   4-Cl        5-Cl    H        S     tBu    O     OEt     OEt                   4-Br        5-Cl    H        S     tBu    O     OEt     OEt                   4-CF.sub.3  5-Br    H        S     tBu    O     OEt     OEt                   4-CF.sub.3  5-F     H        S     tBu    O     OEt     OEt                   4-CF.sub.3  4-Cl    H        S     tBu    O     OEt     OEt                   4-CF.sub.3  4-F     H        S     tBu    O     OEt     OEt                   4-CF.sub.3  H       H        S     tBu    O     OEt     OEt                   4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     tBu    O     OEt     OEt                   4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     tBu    O     OEt     OEt                   4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     tBu    O     OEt     OEt                   4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     tBu    O     OEt     OEt                   4-CF.sub.3  4-F     CO.sub.2 Me                                                                            S     tBu    O     OEt     OEt                   4-CF.sub.3  H       CO.sub.2 Me                                                                            S     tBu    O     OEt     OEt                   4-CF.sub.3  5-Br    H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Br    H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Br    H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-OCF.sub. 3                                                                              5-Br    H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Cl    H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Cl    H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       H        O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-CF.sub.3                                                                            CO.sub.2 Me                                                                            O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     CO.sub.2 Me                                                                            O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            O     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Cl        5-Cl    H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-Br        5-Cl    H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-F     H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-Cl    H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-F     H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       H        S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Cl    CO.sub.2 Me                                                                            S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-Br    CO.sub.2 Me                                                                            S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  5-F     CO.sub.2 Me                                                                            S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  4-Cl    CO.sub.2 Me                                                                            S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub. 3 4-F     CO.sub.2 Me                                                                            S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    4-CF.sub.3  H       CO.sub.2 Me                                                                            S     tBu    O     OCH.sub.2 C(Me).sub.2                                                         CH.sub.2 O                    __________________________________________________________________________

                  TABLE 11                                                        ______________________________________                                         ##STR23##                                                                    R.sub.1       R.sub.2     B            V       R.sub.8  Y'      R.sub.10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    ______________________________________                                        4-CF.sub.3    5-Br        H            O       iPr      O       Et                                                                                                                                                                        4-Cl          5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-Br          5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-OCF.sub.3   5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-Cl          5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-Br          5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    5-CF.sub.3  H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    4-F         H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                    4-CF.sub.3    H           H            O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    5-Br        CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    5-Cl        CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    5-CF.sub.3  CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    4-F         CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    H           CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                  4-CF.sub.3    5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                      4-Cl          5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                4-Br          5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    5-Br        H            S       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    5-F         H            S       iPr      O       Et                                                                                                                                                                                                                                                      4-CF.sub.3    4-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                4-CF.sub.3    4-F         H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              4-CF.sub.3    H           H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                4-CF.sub.3    5-Cl        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-Cl        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-Cl          5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              4-Br          5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-OCF.sub.3   5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-Cl          5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-Br          5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-CF.sub.3  H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-F         H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    H           H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Br        CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Cl        CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-CF.sub.3  CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-F         CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    H           CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-Cl          5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-Br          5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Br        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-F         H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-F         H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    H           H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Cl        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Br        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-F         CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-Cl        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-F         CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    H           CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-OCF.sub.3   5-Br        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Cl        H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-CF.sub.3  H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           H            O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-CF.sub.3  CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           CO.sub.2 Me  O       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-Cl        H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           H            S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-Cl        CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           CO.sub.2 Me  S       iPr      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Br        H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Br        H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-OCF.sub.3   5-Br        H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Cl        H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Cl        H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-CF.sub.3  H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           H            O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        CO.sub.2 Me  O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        CO.sub.2 Me  O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-CF.sub.3  CO.sub.2 Me  O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           CO.sub.2 Me  O       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Cl        H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Cl        H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-Cl        H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           H            S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        CO.sub.2 Me  S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        CO.sub.2 Me  S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         CO.sub.2 Me  S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-Cl        CO.sub.2 Me  S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           CO.sub.2 Me  S       iPr      O       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Br        H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Br        H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-OCF.sub.3   5-Br        H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Cl        H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Cl        H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-CF.sub.3  H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           H            O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        CO.sub.2 Me  O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        CO.sub.2 Me  O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-CF.sub.3  CO.sub.2 Me  O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           CO.sub.2 Me  O       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Cl        H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Cl        H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-Cl        H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           H            S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        CO.sub.2 Me  S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        CO.sub.2 Me  S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         CO.sub.2 Me  S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-Cl        CO.sub.2 Me  S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           CO.sub.2 Me  S       tBu      O       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Cl          5-Br        H            O       iPr      S       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-Br          5-Br        H            O       iPr      S       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-OCF.sub.3   5-Br        H            O       iPr      S       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Cl        H            O       iPr      S       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-Cl          5-Cl        H            O       iPr      S       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-Br          5-Cl        H            O       tBu      S       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-CF.sub.3  H            O       tBu      S       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-F         H            O       tBu      S       Et                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    H           H            O       tBu      S       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub. 3   5-Br        CO.sub.2 Me  O       tBu      S       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    5-Cl        CO.sub.2 Me  O       tBu      S       Ph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-Br        H            S       iPr      S       iPr                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           4-CF.sub.3    5-F         H            S       iPr      S       iPr                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       4-CF.sub.3    4-Cl        H            S       iPr      S       iPr                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           4-CF.sub.3    4-F         H            S       iPr      S       nPr                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           4-CF.sub.3    H           H            S       iPr      S       nPr                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       4-CF.sub.3    5-Cl        CO.sub.2 Me  S       iPr      S       nPr                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           4-CF.sub.3    5-Br        CO.sub.2 Me  S       tBu      S       Me                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    5-F         CO.sub.2 Me  S       tBu      S       Me                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4-CF.sub.3    4-Cl        CO.sub.2 Me  S       tBu      S       Me                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            4-CF.sub.3    4-F         CO.sub.2 Me  S       tBu      S       Me                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  4-CF.sub.3    H           CO.sub.2 Me  S       tBu      S       Me                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ______________________________________                                    

                  TABLE 12                                                        ______________________________________                                         ##STR24##                                                                    R.sub.1   R.sub.2   B        V     R.sub.10                                                                           R.sub.11                              ______________________________________                                        4-CF.sub.3                                                                              5-Br      H        O     Et   Et                                    4-Cl      5-Br      H        O     Et   Et                                    4-Br      5-Br      H        O     Et   Et                                    4-OCF.sub.3                                                                             5-Br      H        O     Et   Et                                    4-CF.sub.3                                                                              5-Cl      H        O     Et   Et                                    4-Cl      5-Cl      H        O     Et   Et                                    4-Br      5-Cl      H        O     Et   Et                                    4-CF.sub.3                                                                              5-CF.sub.3                                                                              H        O     Et   Et                                    4-CF.sub.3                                                                              4-F       H        O     Et   Et                                    4-CF.sub.3                                                                              H         H        O     Et   Et                                    4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            O     Et   Et                                    4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            O     Et   Et                                    4-CF.sub.3                                                                              5-CF.sub.3                                                                              CO.sub.2 Me                                                                            O     Et   Et                                    4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            O     Et   Et                                    4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            O     Et   Et                                    4-CF.sub.3                                                                              5-Cl      H        S     Et   Et                                    4-Cl      5-Cl      H        S     Et   Et                                    4-Br      5-Cl      H        S     Et   Et                                    4-CF.sub.3                                                                              5-Br      H        S     Et   Et                                    4-CF.sub.3                                                                              5-F       H        S     Et   Et                                    4-CF.sub.3                                                                              4-Cl      H        S     Et   Et                                    4-CF.sub.3                                                                              4-F       H        S     Et   Et                                    4-CF.sub.3                                                                              H         H        S     Et   Et                                    4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            S     Et   Et                                    4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            S     Et   Et                                    4-CF.sub.3                                                                              5-F       CO.sub.2 Me                                                                            S     Et   Et                                    4-CF.sub.3                                                                              4-Cl      CO.sub.2 Me                                                                            S     Et   Et                                    4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            S     Et   Et                                    4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            S     Et   Et                                    ______________________________________                                    

                  TABLE 13                                                        ______________________________________                                         ##STR25##                                                                    R.sub.1          R.sub.2       B             V        R.sub.8   R.sub.12      ______________________________________                                        4-CF.sub.3       5-Br          H             O        nBu       nBu           4-Cl             5-Br          H             O        nBu       nBu           4-Br             5-Br          H             O        nBu       nBu           4-OCF.sub.3      5-Br          H             O        nBu       nBu           4-CF.sub.3       5-Cl          H             O        nBu       nBu           4-Cl             5-Cl          H             O        nBu       nBu           4-Br             5-Cl          H             O        nBu       nBu           4-CF.sub.3       5-CF.sub.3    H             O        nBu       nBu           4-CF.sub.3       4-F           H             O        nBu       nBu           4-CF.sub.3       H             H             O        nBu       nBu           4-CF.sub.3       5-Br          CO.sub.2 Me   O        nBu       nBu           4-CF.sub.3       5-Cl          CO.sub.2 Me   O        nBu       nBu           4-CF.sub.3       5-CF.sub.3    CO.sub.2 Me   O        nBu       nBu           4-CF.sub.3       4-F           CO.sub.2 Me   O        nBu       nBu           4-CF.sub.3       H             CO.sub.2 Me   O        nBu       nBu           4-CF.sub.3       5-Cl          H             S        nBu       nBu           4-Cl             5-Cl          H             S        nBu       nBu           4-Br             5-Cl          H             S        nBu       nBu           4-CF.sub.3       5-Br          H             S        nBu       nBu           4-CF.sub.3       5-F           H             S        nBu       nBu           4-CF.sub.3       4-Cl          H             S        nBu       nBu           4-CF.sub.3       4-F           H             S        nBu       nBu           4-CF.sub.3       H             H             S        nBu       nBu           4-CF.sub.3       5-Cl          CO.sub.2 Me   S        nBu       nBu           4-CF.sub.3       5-Br          CO.sub.2 Me   S        nBu       nBu           4-CF.sub.3       5-F           CO.sub.2 Me   S        nBu       nBu           4-CF.sub.3       4-Cl          CO.sub.2 Me   S        nBu       nBu           4-CF.sub.3       4-F           CO.sub.2 Me   S        nBu       nBu           4-CF.sub.3       H             CO.sub.2 Me   S        nBu       nBu           4-CF.sub.3       5-Br          H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-Cl             5-Br          H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-Br             5-Br          H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-OCF.sub.3      5-Br          H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub. 3      5-Cl          H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-Cl             5-Cl          H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-Br             5-Cl          H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-CF.sub.3    H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       4-F           H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       H             H             O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-Br          CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-Cl          CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-CF.sub.3    CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       4-F           CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       H             CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-Cl          H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-Cl             5-Cl          H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-Br             5-Cl          H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-Br          H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-F           H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       4-Cl          H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       4-F           H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       H             H             S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-Cl          CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-Br          CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-F           CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       4-Cl          CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             CH.sub. 2 CH.sub.2                                                            CH.sub.2                4-CF.sub.3       4-F           CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       H             CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             CH.sub.2 CH.sub.2                                                             CH.sub.2                4-CF.sub.3       5-Br          H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-Cl             5-Br          H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-Br             5-Br          H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-OCF.sub.3      5-Br          H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Cl          H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-Cl             5-Cl          H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-Br             5-Cl          H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-CF.sub.3    H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       4-F           H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       H             H             O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Br          CO.sub.2 Me   O        CH.sub. 2 CH.sub.2                                                            OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Cl          CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-CF.sub.3    CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       4-F           CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       H             CO.sub.2 Me   O        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Cl          H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-Cl             5-Cl          H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-Br             5-Cl          H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Br          H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-F           H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       4-Cl          H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       4-F           H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       H             H             S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Cl          CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Br          CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-F           CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       4-Cl          CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       4-F           CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       H             CO.sub.2 Me   S        CH.sub.2 CH.sub.2                                                             OCH.sub.2 CH.sub.2      4-CF.sub.3       5-Br          H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-Cl             5-Br          H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-Br             5-Br          H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-OCF.sub.3      5-Br          H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-Cl          H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-Cl             5-Cl          H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-Br             5-Cl          H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-CF.sub.3    H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       4-F           H             O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       H             H             O        CH.sub.                                                                       2 CHMeOCHMeCH.sub.2                                                           .                       4-CF.sub.3       5-Br          CO.sub.2 Me   O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-Cl          CO.sub.2 Me   O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-CF.sub.3    CO.sub.2 Me   O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       4-F           CO.sub.2 Me   O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       H             CO.sub.2 Me   O        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-Cl          H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-Cl             5-Cl          H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-Br             5-Cl          H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-Br          H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-F           H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       4-Cl          H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       4-F           H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       H             H             S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-Cl          CO.sub.2 Me   S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-Br          CO.sub.2 Me   S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-F           CO.sub.2 Me   S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       4-Cl          CO.sub.2 Me   S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       4-F           CO.sub.2 Me   S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       H             CO.sub.2 Me   S        CH.sub.2 CHMeOCHMeCH                                                          .sub.2                  4-CF.sub.3       5-Br          H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-Cl             5-Br          H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-Br             5-Br          H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-OCF.sub.3      5-Br          H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Cl          H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-Cl             5-Cl          H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-Br             5-Cl          H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-CF.sub.3    H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       4-F           H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       H             H             O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Br          CO.sub.2 Me   O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Cl          CO.sub.2 Me   O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-CF.sub.3    CO.sub.2 Me   O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       4-F           CO.sub.2 Me   O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       H             CO.sub.2 Me   O        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Cl          H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-Cl             5-Cl          H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-Br             5-Cl          H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Br          H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-F           H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       4-Cl          H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       4-F           H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       H             H             S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Cl          CO.sub.2 Me   S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Br          CO.sub.2 Me   S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-F           CO.sub.2 Me   S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       4-Cl          CO.sub.2 Me   S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       4-F           CO.sub.2 Me   S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       H             CO.sub.2 Me   S        Et        cyclo-C.su                                                                    b.6                                                                           H.sub.11      4-CF.sub.3       5-Br          H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-Cl             5-Br          H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-Br             5-Br          H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-OCF.sub.3      5-Br          H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-Cl          H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-Cl             5-Cl          H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-Br             5-Cl          H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-CF.sub.3    H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       4-F           H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       H             H             O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-Br          CO.sub.2 Me   O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-Cl          CO.sub.2 Me   O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-CF.sub.3    CO.sub.2 Me   O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       4-F           CO.sub.2 Me   O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       H             CO.sub.2 Me   O        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-Cl          H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-Cl             5-Cl          H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-Br             5-Cl          H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-Br          H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-F           H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       4-Cl          H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       4-F           H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       H             H             S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-Cl          CO.sub.2 Me   S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-Br          CO.sub.2 Me   S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       5-F           CO.sub.2 Me   S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       4-Cl          CO.sub.2 Me   S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       4-F           CO.sub.2 Me   S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            4-CF.sub.3       H             CO.sub.2 Me   S        iPr       CH.sub.2                                                                      CH.sub.2                                                                      CO.sub.2                                                                      Et            ______________________________________                                    

                  TABLE 14                                                        ______________________________________                                         ##STR26##                                                                    R.sub.1   R.sub.2   B        V      R.sub.10                                  ______________________________________                                        4-CF.sub.3                                                                              5-Br      H        O      tBu                                       4-Cl      5-Br      H        O      tBu                                       4-Br      5-Br      H        O      tBu                                       4-OCF.sub.3                                                                             5-Br      H        O      tBu                                       4-CF.sub.3                                                                              5-Cl      H        O      tBu                                       4-Cl      5-Cl      H        O      tBu                                       4-Br      5-Cl      H        O      tBu                                       4-CF.sub.3                                                                              5-CF.sub.3                                                                              H        O      tBu                                       4-CF.sub.3                                                                              4-F       H        O      tBu                                       4-CF.sub.3                                                                              H         H        O      tBu                                       4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            O      tBu                                       4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            O      tBu                                       4-CF.sub.3                                                                              5-CF.sub.3                                                                              CO.sub.2 Me                                                                            O      tBu                                       4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            O      tBu                                       4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            O      tBu                                       4-CF.sub.3                                                                              5-Cl      H        S      tBu                                       4-Cl      5-Cl      H        S      tBu                                       4-Br      5-Cl      H        S      tBu                                       4-CF.sub.3                                                                              5-Br      H        S      tBu                                       4-CF.sub.3                                                                              5-F       H        S      tBu                                       4-CF.sub.3                                                                              4-Cl      H        S      tBu                                       4-CF.sub.3                                                                              4-F       H        S      tBu                                       4-CF.sub.3                                                                              H         H        S      tBu                                       4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            S      tBu                                       4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            S      tBu                                       4-CF.sub.3                                                                              5-F       CO.sub.2 Me                                                                            S      tBu                                       4-CF.sub.3                                                                              4-Cl      CO.sub.2 Me                                                                            S      tBu                                       4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            S      tBu                                       4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            S      tBu                                       4-Br      5-Cl      H        S      sec-Bu                                    4-CF.sub.3                                                                              5-Br      H        S      sec-Bu                                    4-CF.sub.3                                                                              5-F       H        S      sec-Bu                                    4-CF.sub.3                                                                              4-Cl      H        S      sec-Bu                                    4-CF.sub.3                                                                              4-F       H        S      sec-Bu                                    4-CF.sub.3                                                                              H         H        S      sec-Bu                                    4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            S      sec-Bu                                    4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            S      sec-Bu                                    4-CF.sub.3                                                                              5-F       CO.sub.2 Me                                                                            S      sec-Bu                                    4-CF.sub.3                                                                              4-Cl      CO.sub.2 Me                                                                            S      sec-Bu                                    4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            S      sec-Bu                                    4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            S      sec-Bu                                    4-CF.sub.3                                                                              5-Br      H        O      Ph                                        4-Cl      5-Br      H        O      Ph                                        4-Br      5-Br      H        O      Ph                                        4-OCF.sub.3                                                                             5-Br      H        O      Ph                                        4-CF.sub.3                                                                              5-Cl      H        O      Ph                                        4-Cl      5-Cl      H        O      Ph                                        4-Br      5-Cl      H        O      Ph                                        4-CF.sub.3                                                                              5-CF.sub.3                                                                              H        O      Ph                                        4-CF.sub.3                                                                              4-F       H        O      Ph                                        4-CF.sub.3                                                                              H         H        O      Ph                                        4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            O      Ph                                        4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            O      Ph                                        4-CF.sub.3                                                                              5-CF.sub.3                                                                              CO.sub.2 Me                                                                            O      Ph                                        4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            O      Ph                                        4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            O      Ph                                        4-CF.sub.3                                                                              5-Cl      H        S      Ph                                        4-Cl      5-Cl      H        S      Ph                                        4-Br      5-Cl      H        S      Ph                                        4-CF.sub.3                                                                              5-Br      H        S      Ph                                        4-CF.sub.3                                                                              5-F       H        S      Ph                                        4-CF.sub.3                                                                              4-Cl      H        S      Ph                                        4-CF.sub.3                                                                              4-F       H        S      Ph                                        4-CF.sub.3                                                                              H         H        S      Ph                                        4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            S      Ph                                        4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            S      Ph                                        4-CF.sub.3                                                                              5-F       CO.sub.2 Me                                                                            S      Ph                                        4-CF.sub.3                                                                              4-Cl      CO.sub.2 Me                                                                            S      Ph                                        4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            S      Ph                                        4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            S      Ph                                        4-CF.sub.3                                                                              5-Br      H        O      4-ClPh                                    4-Cl      5-Br      H        O      4-ClPh                                    4-Br      5-Br      H        O      4-ClPh                                    4-OCF.sub.3                                                                             5-Br      H        O      4-ClPh                                    4-CF.sub.3                                                                              5-Cl      H        O      4-ClPh                                    4-Cl      5-Cl      H        O      4-ClPh                                    4-Br      5-Cl      H        O      4-ClPh                                    4-CF.sub.3                                                                              5-CF.sub.3                                                                              H        O      4-ClPh                                    4-CF.sub.3                                                                              4-F       H        O      4-ClPh                                    4-CF.sub.3                                                                              H         H        O      4-ClPh                                    4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            O      4-ClPh                                    4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            O      4-ClPh                                    4-CF.sub.3                                                                              5-CF.sub.3                                                                              CO.sub.2 Me                                                                            O      4-ClPh                                    4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            O      4-ClPh                                    4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            O      4-ClPh                                    4-CF.sub.3                                                                              5-Cl      H        S      4-ClPh                                    4-Cl      5-Cl      H        S      4-ClPh                                    4-Br      5-Cl      H        S      4-ClPh                                    4-CF.sub.3                                                                              5-Br      H        S      4-ClPh                                    4-CF.sub.3                                                                              5-F       H        S      4-ClPh                                    4-CF.sub.3                                                                              4-Cl      H        S      4-ClPh                                    4-CF.sub.3                                                                              4-F       H        S      4-ClPh                                    4-CF.sub.3                                                                              H         H        S      4-ClPh                                    4-CF.sub.3                                                                              5-Cl      CO.sub.2 Me                                                                            S      4-ClPh                                    4-CF.sub.3                                                                              5-Br      CO.sub.2 Me                                                                            S      4-ClPh                                    4-CF.sub.3                                                                              5-F       CO.sub.2 Me                                                                            S      4-ClPh                                    4-CF.sub.3                                                                              4-Cl      CO.sub.2 Me                                                                            S      4-ClPh                                    4-CF.sub.3                                                                              4-F       CO.sub.2 Me                                                                            S      4-ClPh                                    4-CF.sub.3                                                                              H         CO.sub.2 Me                                                                            S      4-ClPh                                    ______________________________________                                    

                  TABLE 15                                                        ______________________________________                                         ##STR27##                                                                    R.sub.1        R.sub.2    R.sub.13.sup.a                                                                              R.sub.13.sup.b                                                                         V        R.sub.8 R.sub.9     ______________________________________                                        4-CF.sub.3     5-F        Me            Me       S        Me      OEt         4-CF.sub.3     5-Cl       Me            Me       S        Me      OEt         4-CF.sub.3     4-F        Me            Me       S        Me      OEt         4-CF.sub.3     5-Br       Ph            H        O        Me      OEt         4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Me      OEt         4-CF.sub.3     5-Br       Me            Me       O        Me      OEt         4-CF.sub.3     5-Cl       Me            Me       O        Me      OEt         4-CF.sub.3     5-F        Me            Me       S        Me      O-nBu       4-CF.sub.3     5-Cl       Me            Me       S        Me      O-nBu       4-CF.sub.3     4-F        Me            Me       S        Me      O-nBu       4-CF.sub.3     5-Br       Ph            H        O        Me      O-nBu       4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Me      O-nBu       4-CF.sub.3     5-Br       Me            Me       O        Me      O-nBu       4-CF.sub.3     5-Cl       Me            Me       O        Me      O-nBu       4-CF.sub.3     5-F        Me            Me       S        Me      O-nHexyl                                                                      N           4-CF.sub.3     5-Cl       Me            Me       S        Me      O-nHexyl                                                                      O           4-CF.sub.3     4-F        Me            Me       S        Me      O-nHexyl                                                                      Z           4-CF.sub.3     5-Br       Ph            H        O        Me      O-nHexyl                                                                      1           4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Me      O-nHexyl                                                                      1           4-CF.sub.3     5-Br       Me            Me       O        Me      O-nHexyl                                                                      5           4-CF.sub.3     5-Cl       Me            Me       O        Me      O-nHexyl                                                                      .           4-CF.sub.3     5-F        Me            Me       S        Me      O-sec-Bu                                                                      s           4-CF.sub.3     5-Cl       Me            Me       S        Me      O-sec-Bu                                                                      u           4-CF.sub.3     4-F        Me            Me       S        Me      O-sec-Bu                                                                      p           4-CF.sub.3     5-Br       Ph            H        O        Me      O-sec-Bu                                                                      .           4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Me      O-sec-Bu                                                                      +           4-CF.sub.3     5-Br       Me            Me       O        Me      O-sec-Bu                                                                      Z           4-CF.sub.3     5-Cl       Me            Me       O        Me      O-sec-Bu                                                                      1           4-CF.sub.3     5-F        Me            Me       S        Me      O-iPr       4-CF.sub.3     5-Cl       Me            Me       S        Me      O-iPr       4-CF.sub.3     4-F        Me            Me       S        Me      O-iPr       4-CF.sub.3     5-Br       Ph            H        O        Me      O-iPr       4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Me      O-iPr       4-CF.sub.3     5-Br       Me            Me       O        Me      O-iPr       4-CF.sub.3     5-Cl       Me            Me       O        Me      O-iPr       4-CF.sub.3     5-F        Me            Me       S        Me      OCH.sub.                                                                      2                                                                             CH.sub.2                                                                       OEt        4-CF.sub.3     5-Cl       Me            Me       S        Me      OCH.sub.                                                                      2                                                                             CH.sub.2                                                                       OEt        4-CF.sub.3     4-F        Me            Me       S        Me      OCH.sub.                                                                      2                                                                             CH.sub.2                                                                       OEt        4-CF.sub.3     5-Br       Ph            H        O        Me      OCH.sub.                                                                      2                                                                             CH.sub.2                                                                       OEt        4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Me      OCH.sub.                                                                      2                                                                             CH.sub.2                                                                       OEt        4-CF.sub.3     5-Br       Me            Me       O        Me      OCH.sub.                                                                      2                                                                             CH.sub.2                                                                       OEt        4-CF.sub.3     5-Cl       Me            Me       O        Me      OCH.sub.                                                                      2                                                                             CH.sub.2                                                                       OEt        4-CF.sub.3     5-F        Me            Me       S        Me      F           4-CF.sub.3     5-Cl       Me            Me       S        Me      F           4-CF.sub.3     4-F        Me            Me       S        Me      F           4-CF.sub.3     5-Br       Ph            H        O        Me      F           4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Me      F           4-CF.sub.3     5-Br       Me            Me       O        Me      F           4-CF.sub.3     5-Cl       Me            Me       O        Me      F           4-CF.sub.3     5-F        Me            Me       S        Me      NMe.sub.                                                                      2           4-CF.sub.3     5-Cl       Me            Me       S        Me      NMe.sub.                                                                      2           4-CF.sub.3     4-F        Me            Me       S        Me      NMe.sub.                                                                      2           4-CF.sub.3     5-Br       Ph            H        O        Me      NMe.sub.                                                                      2           4-CF.sub. 3    5-Br       CO.sub.2 Me   H        O        Me      NMe.sub.                                                                      2           4-CF.sub.3     5-Br       Me            Me       O        Me      NMe.sub.                                                                      2           4-CF.sub.3     5-Cl       Me            Me       O        Me      NMe.sub.                                                                      2           4-CF.sub.3     5-F        Me            Me       S        Et      O-iPr       4-CF.sub.3     5-Cl       Me            Me       S        Et      O-iPr       4-CF.sub.3     4-F        Me            Me       S        Et      O-iPr       4-CF.sub.3     5-Br       Ph            H        O        Et      O-iPr       4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        Et      O-iPr       4-CF.sub.3     5-Br       Me            Me       O        Et      O-iPr       4-CF.sub.3     5-Cl       Me            Me       O        Et      O-iPr       4-CF.sub.3     5-F        Me            Me       S        iPr     OEt         4-CF.sub.3     5-Cl       Me            Me       S        iPr     OEt         4-CF.sub.3     4-F        Me            Me       S        iPr     OEt         4-CF.sub.3     5-Br       Ph            H        O        iPr     OEt         4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        iPr     OEt         4-CF.sub.3     5-Br       Me            Me       O        iPr     OEt         4-CF.sub.3     5-Cl       Me            Me       O        iPr     OEt         4-CF.sub.3     5-F        Me            Me       S        iPr     OCH.sub.                                                                      2                                                                             CF.sub.3                                                                      .           4-CF.sub.3     5-Cl       Me            Me       S        iPr     OCH.sub.                                                                      2                                                                             CF.sub.3                                                                      u           4-CF.sub.3     4-F        Me            Me       S        iPr     OCH.sub.                                                                      2                                                                             CF.sub.3                                                                      .           4-CF.sub.3     5-Br       Ph            H        O        iPr     OCH.sub.                                                                      2                                                                             CF.sub.3                                                                      Z           4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        iPr     OCH.sub.                                                                      2                                                                             CF.sub.                                                                       3           4-CF.sub.3     5-Br       Me            Me       O        iPr     OCH.sub.                                                                      2                                                                             CF.sub.3                                                                      .           4-CF.sub.3     5-Cl       Me            Me       O        iPr     OCH.sub.                                                                      2                                                                             CF.sub.3                                                                      u           4-CF.sub.3     5-F        Me            Me       S        iPr     OCH.sub.                                                                      2                                                                             CO.sub.2                                                                       Me         4-CF.sub.3     5-Cl       Me            Me       S        iPr     OCH.sub.                                                                      2                                                                             CO.sub.2                                                                       Me         4-CF.sub.3     4-F        Me            Me       S        iPr     OCH.sub.                                                                      2                                                                             CO.sub.2                                                                       Me         4-CF.sub.3     5-Br       Ph            H        O        iPr     OCH.sub.                                                                      2                                                                             CO.sub.2                                                                       Me         4-CF.sub.3     5-Br       CO.sub.2 Me   H        O        iPr     OCH.sub.                                                                      2                                                                             CO.sub.2                                                                       Me         4-CF.sub.3     5-Br       Me            Me       O        iPr     OCH.sub.                                                                      2                                                                             CO.sub.2                                                                       Me         4-CF.sub.3     5-Cl       Me            Me       O        iPr     OCH.sub.                                                                      2                                                                             CO.sub.2    ______________________________________                                                                                                          Me                                                                            +       

                                      TABLE 16                                    __________________________________________________________________________     ##STR28##                                                                    R.sub.1           R.sub.2   R.sub.3     R.sub.8 R.sub.9                       __________________________________________________________________________    4-CF.sub.3        4-Cl      H           Me      OEt                           4-Cl              4-Cl      H           Me      OEt                           4-Br              4-Cl      H           Me      OEt                           4-OCF.sub.3       4-Cl      H           Me      OEt                           4-OCF.sub.2 H     4-Cl      H           Me      OEt                           3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-Cl      H           Me      OEt                           4-CF.sub.3        4-F       H           Me      OEt                           4-Cl              4-F       H           Me      OEt                           4-Br              4-F       H           Me      OEt                           4-OCF.sub.3       4-F       H           Me      OEt                           4-OCF.sub.2 H     4-F       H           Me      OEt                           3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-F       H           Me      OEt                           4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Me      OEt                           4-Cl              4-OCF.sub.2 H                                                                           H           Me      OEt                           4-Br              4-OCF.sub.2 H                                                                           H           Me      OEt                           4-OCF.sub. 3      4-OCF.sub.2 H                                                                           H           Me      OEt                           4-OCF.sub.2 H     4-OCF.sub.2 H                                                                           H           Me      OEt                           3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-OCF.sub.2 H                                                                           H           Me      OEt                           4-CF.sub.3        4-Br      H           Me      OEt                           4-CF.sub.3        4-Cl      4-Cl        Me      OEt                           4-Cl              4-Cl      4-Cl        Me      OEt                           4-Br              4-Cl      4-Cl        Me      OEt                           4-OCF.sub.3       4-Cl      4-Cl        Me      OEt                           4-OCF.sub.2 H     4-Cl      4-Cl        Me      OEt                           3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-Cl      4-Cl        Me      OEt                           4-CF.sub.3        4-F       4-Cl        Me      OEt                           4-OCF.sub.3       4-F       4-Cl        Me      OEt                           4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        Me      OEt                           4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        Me      OEt                           4-CF.sub.3        4-Cl      4-CN        Me      OEt                           4-Cl              4-Cl      4-CN        Me      OEt                           4-OCF.sub.3       4-Cl      4-CN        Me      OEt                           4-CF.sub.3        4-F       4-CN        Me      OEt                           4-OCF.sub.3       4-F       4-CN        Me      OEt                           4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             Me      OEt                           4-CF.sub.3        4-Cl      H           Me      O-n-Bu                        4-OCF.sub.3       4-Cl      H           Me      O-n-Bu                        4-CF.sub.3        4-F       H           Me      O-n-Bu                        4-OCF.sub.3       4-F       H           Me      O-n-Bu                        3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-F       H           Me      O-n-Bu                        4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Me      O-n-Bu                        4-Cl              4-OCF.sub.2 H                                                                           H           Me      O-n-Bu                        4-Br              4-OCF.sub.2 H                                                                           H           Me      O-n-Bu                        4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           Me      O-n-Bu                        4-CF.sub. 3       4-Br      H           Me      O-n-Bu                        4-CF.sub.3        4-Cl      4-Cl        Me      O-n-Bu                        4-Cl              4-Cl      4-Cl        Me      O-n-Bu                        4-Br              4-Cl      4-Cl        Me      O-n-Bu                        4-OCF.sub.3       4-Cl      4-Cl        Me      O-n-Bu                        4-CF.sub.3        4-F       4-Cl        Me      O-n-Bu                        4-OCF.sub.3       4-F       4-Cl        Me      O-n-Bu                        4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        Me      O-n-Bu                        4-Cl              4-OCF.sub.2 H                                                                           4-Cl        Me      O-n-Bu                        4-Br              4-OCF.sub.2 H                                                                           4-Cl        Me      O-n-Bu                        4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        Me      O-n-Bu                        4-CF.sub.3        4-Cl      4-CN        Me      O-n-Bu                        4-OCF.sub.3       4-Cl      4-CN        Me      O-n-Bu                        4-CF.sub.3        4-F       4-CN        Me      O-n-Bu                        4-OCF.sub.3       4-F       4-CN        Me      O-n-Bu                        4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             Me      O-n-Bu                        4-CF.sub.3        4-OMe     4-Cl        Me      O-n-Bu                        4-Cl              4-OPh     4-Cl        Me      O-n-Bu                        4-Br              4-SCF.sub.2 H                                                                           4-Cl        Me      O-n-Bu                        4-OCF.sub.3       4-NO.sub.2                                                                              4-Cl        Me      O-n-Bu                        4-OCF.sub.2 H     4-SMe     4-Cl        Me      O-n-Bu                        3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-SO.sub.2 Me                                                                           4-Cl        Me      O-n-Bu                        4-CF.sub.3        4-CN      4-Cl        Me      O-n-Bu                        4-Cl              3-Cl      4-Cl        Me      O-n-Bu                        4-Br              3-F       4-Cl        Me      O-n-Bu                        4-OCF.sub.3       4-Me      4-Cl        Me      O-n-Bu                        4-OCF.sub.2 H     4-allyl   4-Cl        Me      O-n-Bu                        3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-CF.sub.3                                                                              4-Cl        Me      O-n-Bu                        4-CF.sub.3        4-Cl      4-CO.sub.2 Et                                                                             Me      O-n-Bu                        4-Cl              4-Cl      4-OMe       Me      O-n-Bu                        4-Br              4-Cl      4-SCF.sub.2 CF.sub.2 H                                                                    Me      O-n-Bu                        4-OCF.sub.3       4-Cl      4-OCF.sub.2 CF.sub.2 H                                                                    Me      O-n-Bu                        4-OCF.sub.2 H     4-Cl      4-OPh       Me      O-n-Bu                        3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-CF.sub.3                                                                              4-CF.sub.3  Me      O-n-Bu                        4-CF.sub.3        4-Cl      4-CF.sub.3  Me      O-n-Bu                        4-Cl              4-Cl      4-Me        Me      O-n-Bu                        4-Br              4-Cl      3-Cl        Me      O-n-Bu                        4-OCF.sub.3       4-Cl      3-Br        Me      O-n-Bu                        4-OCF.sub.2 H     4-Cl      4-NO.sub.2  Me      O-n-Bu                        4-CF.sub.3        4-Cl      H           Me      O-n-hexyl                     4-CF.sub.3        4-F       H           Me      O-n-hexyl                     4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Me      O-n-hexyl                     4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           Me      O-n-octyl                     4-CF.sub.3        4-Br      H           Me      O-n-octyl                     4-CF.sub.3        4-Cl      4-Cl        Me      O-n-octyl                     4-Cl              4-Cl      4-Cl        Me      O-n-octyl                     4-Br              4-Cl      4-Cl        Me      O-n-octyl                     4-OCF.sub.3       4-Cl      4-Cl        Me      O-n-octyl                     4-CF.sub.3        4-F       4-Cl        Me      O-n-decyl                     4-Cl              4-F       4-Cl        Me      O-n-decyl                     4-OCF.sub.3       4-F       4-Cl        Me      O-n-decyl                     4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        Me      O-n-decyl                     4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        Me      O-n-decyl                     4-CF.sub.3        4-Cl      4-CN        Me      O-n-decyl                     4-Cl              4-Cl      4-CN        Me      O-n-decyl                     4-Br              4-Cl      4-CN        Me      O-n-decyl                     4-OCF.sub.3       4-Cl      4-CN        Me      O-n-dodecyl                   4-CF.sub.3        4-F       4-CN        Me      O-n-dodecyl                   4-OCF.sub.3       4-F       4-CN        Me      O-n-dodecyl                   4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             Me      O-n-dodecyl                   4-CF.sub.3        4-Cl      H           Me      O-sec-Bu                      4-Cl              4-Cl      H           Me      O-sec-Bu                      4-OCF.sub.3       4-Cl      H           Me      O-sec-Bu                      4-CF.sub.3        4-F       H           Me      O-sec-Bu                      4-OCF.sub.3       4-F       H           Me      O-sec-Bu                      4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Me      O-sec-Bu                      4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           Me      O-sec-Bu                      4-CF.sub.3        4-Br      H           Me      O-sec-Bu                      4-CF.sub.3        4-Cl      4-Cl        Me      O-sec-Bu                      4-Cl              4-Cl      4-Cl        Me      O-sec-Bu                      4-Br              4-Cl      4-Cl        Me      O-sec-Bu                      4-OCF.sub.3       4-Cl      4-Cl        Me      O-sec-Bu                      4-CF.sub.3        4-F       4-Cl        Me      O-sec-Bu                      4-Cl              4-F       4-Cl        Me      O-sec-Bu                      4-OCF.sub.3       4-F       4-Cl        Me      O-sec-Bu                      4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        Me      O-sec-Bu                      4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        Me      O-sec-Bu                      4-CF.sub.3        4-Cl      4-CN        Me      O-sec-Bu                      4-Cl              4-Cl      4-CN        Me      O-sec-Bu                      4-OCF.sub.3       4-Cl      4-CN        Me      O-sec-Bu                      4-CF.sub.3        4-F       4-CN        Me      O-sec-Bu                      4-OCF.sub.3       4-F       4-CN        Me      O-sec-Bu                      4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             Me      O-sec-Bu                      4-CF.sub.3        4-CN      4-Cl        Me      O-sec-Bu                      4-Cl              3-Cl      4-Cl        Me      O-sec-Bu                      4-Br              3-F       4-Cl        Me      O-sec-Bu                      4-OCF.sub.3       4-Me      4-Cl        Me      O-sec-Bu                      4-CF.sub.3        4-Cl      4-CO.sub.2 Et                                                                             Me      O-sec-Bu                      4-Cl              4-Cl      4-OMe       Me      O-sec-Bu                      4-Br              4-Cl      4-SCF.sub.2 CF.sub.2 H                                                                    Me      O-sec-Bu                      4-OCF.sub.3       4-Cl      4-OCF.sub.2 CF.sub.2 H                                                                    Me      O-sec-Bu                      4-OCF.sub.2       4-Cl      4-OPh       Me      O-sec-Bu                      3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-Cl      4-CF.sub.3  Me      O-sec-Bu                      4-CF.sub.3        4-Cl      4-CF.sub.3  Me      O-sec-Bu                      4-Cl              4-Cl      4-Me        Me      O-sec-Bu                      4-Br              4-Cl      3-Cl        Me      O-sec-Bu                      4-OCF.sub.3       4-Cl      3-Br        Me      O-sec-Bu                      4-OCF.sub.2 H     4-Cl      4-NO.sub.2  Me      O-sec-Bu                      4-CF.sub.3        4-Cl      H           Me      O-iPr                         4-OCF.sub.3       4-Cl      H           Me      O-iPr                         4-CF.sub.3        4-F       H           Me      O-iPr                         4-OCF.sub.3       4-F       H           Me      O-iPr                         4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Me      O-iPr                         4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           Me      O-iPr                         4-CF.sub.3        4-Br      H           Me      O-iPr                         4-OCF.sub.3       4-Br      H           Me      O-iPr                         4-CF.sub.3        4-Cl      4-Cl        Me      O-iPr                         4-OCF.sub.3       4-Cl      4-Cl        Me      O-iPr                         4-CF.sub.3        4-F       4-Cl        Me      O-iPr                         4-OCF.sub.3       4-F       4-Cl        Me      O-iPr                         4-CF.sub.3        4-Cl      4-CN        Me      O-iPr                         4-OCF.sub.3       4-Cl      4-CN        Me      O-iPr                         4-CF.sub.3        4-F       4-CN        Me      O-iPr                         4-OCF.sub.3       4-F       4-CN        Me      O-iPr                         4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             Me      O-iPr                         4-CF.sub.3        4-Cl      H           Me      OCH.sub.2 CH.sub.2 OEt        4-CF.sub.3        4-F       H           Me      OCH.sub.2 CH.sub.2 OEt        4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Me      OCH.sub.2 CH.sub.2 OEt        4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           Me      OCH.sub.2 CCl.sub.3           4-CF.sub.3        4-Br      H           Me      OCH.sub.2 CCl.sub.3           4-CF.sub. 3       4-Cl      4-Cl        Me      OCH.sub.2 CCl.sub.3           4-Cl              4-Cl      4-Cl        Me      OCH.sub.2 CCl.sub.3           4-OCF.sub.3       4-Cl      4-Cl        Me      OCH.sub.2 CCl.sub.3           4-CF.sub.3        4-F       4-Cl        Me      OCH.sub.2 CF.sub.3            4-OCF.sub.3       4-F       4-Cl        Me      OCH.sub.2 CF.sub.3            4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        Me      OCH.sub.2 CF.sub.3            4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        Me      OCH.sub.2 CF.sub.3            4-CF.sub.3        4-Cl      4-CN        Me      OCH.sub.2 CF.sub.3            4-OCF.sub.3       4-Cl      4-CN        Me      OCH.sub.2 CO.sub.2 Et         4-CF.sub.3        4-F       4-CN        Me      OCH.sub.2 CO.sub.2 Et         4-OCF.sub.3       4-F       4-CN        Me      OCH.sub.2 CO.sub.2 Et         4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             Me      OCH.sub.2 CO.sub.2 Et         4-CF.sub.3        4-Cl      H           Me      F                             4-Cl              4-Cl      H           Me      F                             4-OCF.sub.3       4-Cl      H           Me      F                             4-CF.sub.3        4-F       H           Me      F                             4-OCF.sub.3       4-F       H           Me      F                             4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Me      F                             4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           Me      NMe.sub.2                     4-CF.sub.3        4-Br      H           Me      NMe.sub.2                     4-CF.sub.3        4-Cl      4-Cl        Me      NMe.sub.2                     4-Cl              4-Cl      4-Cl        Me      NMe.sub.2                     4-OCF.sub.3       4-Cl      4-Cl        Me      NME.sub.2                     4-CF.sub.3        4-F       4-Cl        Me      NEt.sub.2                     4-OCF.sub.3       4-F       4-Cl        Me      NEt.sub.2                     4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        Me      piperidino                    4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        Me      morpholino                    4-CF.sub.3        4-Cl      4-CN        Me      n-Pr                          4-OCF.sub.3       4-Cl      4-CN        Me      n-Pr                          4-CF.sub.3        4-F       4-CN        Me      Sec-Bu                        4-OCF.sub.3       4-F       4-CN        Me      4-ClPh                        4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             Me      Ph                            4-CF.sub.3        4-Cl      H           Et      O-iPr                         4-Cl              4-Cl      H           Et      O-iPr                         4-OCF.sub.3       4-Cl      H           Et      O-iPr                         4-CF.sub.3        4-F       H           Et      O-iPr                         4-OCF.sub.3       4-F       H           Et      O-iPr                         4-CF.sub.3        4-OCF.sub.2 H                                                                           H           Et      O-iPr                         4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           Et      O-iPr                         4-CF.sub.3        4-Br      H           Et      O-iPr                         4-CF.sub.3        4-Cl      4-Cl        Et      O-iPr                         4-OCF.sub.3       4-Cl      4-Cl        Et      O-iPr                         4-CF.sub.3        4-F       4-Cl        Et      OEt                           4-OCF.sub.3       4-F       4-Cl        Et      OEt                           4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        Et      OCH.sub.2 CCl.sub.3           4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        Et      NEt.sub.2                     4-CF.sub.3        4-Cl      4-CN        Et      2,6-di-Me-morpholino          4-OCF.sub.3       4-Cl      4-CN        Et      2,6-di-Me-morpholino          4-CF.sub.3        4-F       4-CN        Et      iPr                           4-OCF.sub.3       4-F       4-CN        Et      Ph                            3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-F       4-CN        Et      Ph                            4-CF.sub.3        4-Cl      H           iPr     OEt                           4-OCF.sub.3       4-Cl      H           iPr     OEt                           4-CF.sub.3        4-F       H           iPr     OEt                           4-CF.sub.3        4-OCF.sub.2 H                                                                           H           iPr     OEt                           4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           iPr     OEt                           4-CF.sub.3        4-Br      H           iPr     OEt                           4-CF.sub.3        4-Cl      4-Cl        iPr     OEt                           4-Cl              4-Cl      4-Cl        iPr     OEt                           4-Br              4-Cl      4-Cl        iPr     OEt                           4-OCF.sub.3       4-Cl      4-Cl        iPr     OEt                           4-CF.sub.3        4-F       4-Cl        iPr     OEt                           4-OCF.sub.3       4-F       4-Cl        iPr     OEt                           4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        iPr     OEt                           4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        iPr     OEt                           4-CF.sub.3        4-Cl      4-CN        iPr     OEt                           4-OCF.sub.3       4-Cl      4-CN        iPr     OEt                           4-CF.sub.3        4-F       4-CN        iPr     OEt                           4-OCF.sub.3       4-F       4-CN        iPr     OEt                           4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             iPr     OEt                           4-CF.sub.3        4-CN      4-Cl        iPr     OEt                           4-Cl              3-Cl      4-Cl        iPr     OEt                           4-Br              3-F       4-Cl        iPr     OEt                           4-OCF.sub.3       4-Me      4-Cl        iPr     OEt                           4-OCF.sub.2 H     4-o-allyl 4-Cl        iPr     OEt                           3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-CF.sub.3                                                                              4-Cl        iPr     OEt                           4-CF.sub.3        4-Cl      4-CO.sub.2 Et                                                                             iPr     OEt                           4-Cl              4-Cl      4-OMe       iPr     OEt                           4-Br              4-Cl      4-SCF.sub.2 CF.sub.2 H                                                                    iPr     OEt                           4-OCF.sub.3       4-Cl      4-OCF.sub.2 CF.sub.2 H                                                                    iPr     OEt                           4-OCF.sub.2 H     4-Cl      4-OPh       iPr     OEt                           3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-Cl      4-CF.sub.3  iPr     OEt                           4-CF.sub.3        4-Cl      4-CF.sub.3  iPr     OEt                           4-Br              4-Cl      3-Cl        iPr     OEt                           4-OCF.sub.3       4-Cl      3-Br        iPr     OEt                           4-OCF.sub.2 H     4-Cl      4-NO.sub.2  iPr     OEt                           4-CF.sub.3        4-Cl      H           iPr     O-n-Bu                        4-Cl              4-Cl      H           iPr     O-n-Bu                        4-Br              4-Cl      H           iPr     O-n-Bu                        4-OCF.sub.3       4-Cl      H           iPr     O-n-Bu                        4-CF.sub.3        4-F       H           iPr     O-n-Bu                        4-OCF.sub.3       4-F       H           iPr     O-n-Bu                        4-CF.sub.3        4-OCF.sub.2 H                                                                           H           iPr     O-n-Bu                        4-OCF.sub.3       4-OCF.sub.2 H                                                                           H           iPr     O-n-Bu                        4-CF.sub.3        4-Br      H           iPr     O-n-Bu                        4-CF.sub.3        4-Cl      4-Cl        iPr     O-n-Bu                        4-Br              4-Cl      4-Cl        iPr     O-n-Bu                        4-OCF.sub.3       4-Cl      4-Cl        iPr     O-n-Bu                        4-CF.sub.3        4-F       4-Cl        iPr     OCH.sub.2 CF.sub.3            4-OCF.sub.3       4-F       4-Cl        iPr     OCH.sub.2 CF.sub.3            4-CF.sub.3        4-OCF.sub.2 H                                                                           4-Cl        iPr     OCH.sub.2 CO.sub.2 Me         4-OCF.sub.3       4-OCF.sub.2 H                                                                           4-Cl        iPr     NMe.sub.2                     4-CF.sub.3        4-Cl      4-CN        iPr     NEt.sub.2                     4-OCF.sub.3       4-Cl      4-CN        iPr     NEt.sub.2                     4-CF.sub.3        4-F       4-CN        iPr     piperidino                    4-OCF.sub.3       4-F       4-CN        iPr     Et                            4-CF.sub.3        4-Cl      4-CO.sub.2 Me                                                                             iPr     Ph                            3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-Cl      4-CO.sub.2 Me                                                                             iPr     Ph                            4-CF.sub.3        4-Cl      H           CH.sub.2 Ph                                                                           OEt                           4-CF.sub.3        4-OCF.sub.2 H                                                                           H           CH.sub.2 Ph                                                                           piperidino                    4-CF.sub.3        4-Br      H           CH Ph   OCH.sub.2 CH.sub. 2 OEt       4-CF.sub.3        4-Cl      4-Cl        CH.sub.2 Ph                                                                           Me                            __________________________________________________________________________

                                      TABLE 17                                    __________________________________________________________________________     ##STR29##                                                                    R.sub.1            R.sub.2   R.sub.3   R.sub.8 R.sub.9                        __________________________________________________________________________    4-CF.sub.3         4-Cl      H         Me      NMe.sub.2                      4-OCF.sub.3        4-Cl      H         Me      NMe.sub.2                      4-CF.sub.3         4-F       H         Me      NMe.sub.2                      4-OCF.sub.3        4-F       H         Me      NMe.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           H         Me      NMe.sub.2                      4-OCF.sub.3        4-OCF.sub.2 H                                                                           H         Me      NMe.sub.2                      4-CF.sub.3         4-Cl      4-Cl      Me      NMe.sub.2                      4-Cl               4-Cl      4-Cl      Me      NMe.sub.2                      4-Br               4-Cl      4-Cl      Me      NMe.sub.2                      4-OCF.sub.3        4-Cl      4-Cl      Me      NMe.sub.2                      4-CF.sub.3         4-F       4-Cl      Me      NMe.sub.2                      4-OCF.sub.3        4-F       4-Cl      Me      NMe.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           4-Cl      Me      NMe.sub.2                      4-OCF.sub.3        4-OCF.sub.2 H                                                                           4-Cl      Me      NMe.sub.2                      4-CF.sub.3         4-Cl      4-CN      Me      NMe.sub.2                      4-Cl               4-Cl      4-CN      Me      NMe.sub.2                      4-Br               4-Cl      4-CN      Me      NMe.sub.2                      4-OCF.sub.3        4-Cl      4-CN      Me      NMe.sub.2                      4-CF.sub.3         4-F       4-CN      Me      NMe.sub.2                      4-OCF.sub.3        4-F       4-CN      Me      NMe.sub.2                      4-CF.sub.3         4-Cl      4-CO.sub.2 Me                                                                           Me      NMe.sub.2                      4-CF.sub.3         4-Cl      H         Me      NEt.sub.2                      3,4-CH.sub.2 C(Me).sub.2 O                                                                       4-Cl      H         Me      NEt.sub.2                      4-CF.sub.3         4-F       H         Me      NEt.sub.2                      4-OCF.sub.3        4-F       H         Me      NEt.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           H         Me      NEt.sub.2                      4-OCF.sub.3        4-OCF.sub.2 H                                                                           H         Me      NEt.sub.2                      4-CF.sub.3         4-Br      H         Me      NEt.sub.2                      3,4-CH.sub.2 C(Me).sub.2 O                                                                       4-Br      H         Me      NEt.sub.2                      4-CF.sub.3         4-Cl      4-Cl      Me      NEt.sub.2                      4-Cl               4-Cl      4-Cl      Me      NEt.sub.2                      4-Br               4-Cl      4-Cl      Me      NEt.sub.2                      4-OCF.sub.3        4-Cl      4-Cl      Me      NEt.sub.2                      4-CF.sub.3         4-F       4-Cl      Me      NEt.sub.2                      4-OCF.sub.3        4-F       4-Cl      Me      NEt.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           4-Cl      Me      NEt.sub.2                      4-OCF.sub.3        4-OCF.sub.2 H                                                                           4-Cl      Me      NEt.sub.2                      4-OCF.sub.2 H      4-OCF.sub.2 H                                                                           4-Cl      Me      NEt.sub.2                      3,4-CH.sub.2 C(Me).sub.2 O                                                                       4-OCF.sub.2 H                                                                           4-Cl      Me      NEt.sub.2                      4-CF.sub. 3        4-Cl      4-CN      Me      NEt.sub.2                      4-OCF.sub.3        4-Cl      4-CN      Me      NEt.sub.2                      4-CF.sub.3         4-F       4-CN      Me      NEt.sub.2                      4-OCF.sub.3        4-F       4-CN      Me      NEt.sub.2                      4-CF.sub.3         4-Cl      4-CO.sub.2 Me                                                                           Me      NEt.sub.2                      4-CF.sub.3         4-Cl      H         Me      piperidino                     4-OCF.sub.3        4-Cl      H         Me      piperidino                     4-CF.sub.3         4-F       H         Me      Sec-Bu                         4-OCF.sub.3        4-F       H         Me      n-hexyl                        4-CF.sub.3         4-OCF.sub.2 H                                                                           H         Me      Ph                             4-OCF.sub.3        4-OCF.sub.2 H                                                                           H         Me      Ph                             4-CF.sub.3         4-Br      H         Me      4-ClPh                         4-Cl               4-Br      H         Me      4-ClPh                         4-CF.sub.3         4-Cl      4-Cl      Me      n-Bu                           4-Cl               4-Cl      4-Cl      Me      n-Bu                           4-Br               4-Cl      4-Cl      Me      n-Bu                           4-OCF.sub.3        4-Cl      4-Cl      Me      n-Bu                           4-CF.sub.3         4-F       4-Cl      Et      NMe.sub.2                      4-OCF.sub.3        4-F       4-Cl      Et      NMe.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           4-Cl      Et      NEt.sub.2                      4-OCF.sub.3        4-OCF.sub.2 H                                                                           4-Cl      Et      morpholino                     4-CF.sub.3         4-Cl      4-CN      Et      iPr                            3,4-CH.sub.2 C(Me).sub.2 O                                                                       4-Cl      4-CN      Et      n-Bu                           4-CF.sub.3         4-F       4-CN      Et      n-Bu                           4-CF.sub.3         4-Cl      4-CO.sub.2 Me                                                                           Et      4-MeOPh                        4-CF.sub.3         4-Cl      H         iPr     NMe.sub.2                      4-Cl               4-Cl      H         iPr     NMe.sub.2                      4-Br               4-Cl      H         iPr     NMe.sub.2                      4-OCF.sub.3        4-Cl      H         iPr     NMe.sub.2                      4-CF.sub.3         4-F       H         iPr     NMe.sub.2                      4-OCF.sub.3        4-F       H         iPr     NMe.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           H         iPr     NMe.sub.2                      4-OCF.sub.3        4-OCF.sub.2 H                                                                           H         iPr     NMe.sub.2                      3,4-CH.sub.2 C(Me).sub.2 O                                                                       4-OCF.sub.2 H                                                                           H         iPr     NMe.sub.2                      4-CF.sub.3         4-Br      H         iPr     NMe.sub.2                      4-CF.sub.3         4-Cl      4-Cl      iPr     NMe.sub.2                      4-Cl               4-Cl      4-Cl      iPr     NMe.sub.2                      4-Br               4-Cl      4-Cl      iPr     NMe.sub.2                      4-OCF.sub.3        4-Cl      4-Cl      iPr     NMe.sub.2                      4-CF.sub.3         4-F       4-Cl      iPr     NEt.sub.2                      4-OCF.sub.3        4-F       4-Cl      iPr     NEt.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           4-Cl      iPr     2,6-di-Me-morpholino           4-OCF.sub.3        4-OCF.sub.2 H                                                                           4-Cl      iPr     piperidino                     4-CF.sub.3         4-Cl      4-CN      iPr     Et                             4-OCF.sub.3        4-Cl      4-CN      iPr     Et                             4-CF.sub.3         4-F       4-CN      iPr     n-Bu                           4-OCF.sub.3        4-F       4-CN      iPr     Ph                             4-CF.sub.3         4-Cl      4-CO.sub.2 Me                                                                           iPr     4-ClPh                         __________________________________________________________________________

                                      TABLE 18                                    __________________________________________________________________________     ##STR30##                                                                    R.sub.1      R.sub.2  R.sub.3  R.sub.8                                                                            Y.sup.1                                                                              Y.sup.1 R.sub.10                                                                       Y.sup.1 R.sub.11          __________________________________________________________________________    4-CF.sub.3   4-Cl     H        tBu  S      OEt      OEt                       4-OCF.sub.3  4-Cl     H        tBu  S      OEt      OEt                       4-CF.sub.3   4-F      H        tBu  S      OEt      OEt                       4-OCF.sub.3  4-F      H        tBu  S      OEt      OEt                       4-CF.sub.3   4-OCF.sub.2 H                                                                          H        tBu  S      OEt      OEt                       4-OCF.sub.3  4-OCF.sub.2 H                                                                          H        tBu  S      OEt      OEt                       4-CF.sub.3   4-Br     H        tBu  S      OEt      OEt                       4-CF.sub.3   4-Cl     4-Cl     tBu  S      OEt      OEt                       4-Cl         4-Cl     4-Cl     tBu  S      OEt      OEt                       4-Br         4-Cl     4-Cl     tBu  S      OEt      OEt                       4-OCF.sub.3  4-Cl     4-Cl     tBu  S      OEt      OEt                       4-CF.sub.3   4-F      4-Cl     tBu  S      OEt      OEt                       4-OCF.sub.3  4-F      4-Cl     tBu  S      OEt      OEt                       4-CF.sub.3   4-OCF.sub.2 H                                                                          4-Cl     tBu  S      OEt      OEt                       4-Br         4-OCF.sub.2 H                                                                          4-Cl     tBu  S      OEt      OEt                       4-OCF.sub.3  4-OCF.sub.2 H                                                                          4-Cl     tBu  S      OEt      OEt                       4-CF.sub.3   4-Cl     4-CN     tBu  S      OEt      OEt                       4-OCF.sub.3  4-Cl     4-CN     tBu  S      OEt      OEt                       4-CF.sub.3   4-F      4-CN     tBu  S      OEt      OEt                       4-OCF.sub.3  4-F      4-CN     tBu  S      OEt      OEt                       4-CF.sub.3   4-Cl     4-CO.sub.2 Me                                                                          tBu  S      OEt      OEt                       4-CF.sub.3   4-Cl     H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-Cl     H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-F      H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-Cl         4-F      H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-F      H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-OCF.sub.2 H                                                                          H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-OCF.sub.2 H                                                                          H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Br     H        tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-Cl         4-Cl     4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-Br         4-Cl     4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-Cl     4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-F      4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-F      4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-OCF.sub.2 H                                                                          4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-OCF.sub.2 H                                                                          4-Cl     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     4-CN     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-Cl     4-CN     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-F      4-CN     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-F      4-CN     tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     4-CO.sub.2 Me                                                                          tBu  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     H        iPr  S      OEt      OEt                       4-Cl         4-Cl     H        iPr  S      OEt      OEt                       4-OCF.sub.3  4-Cl     H        iPr  S      OEt      OEt                       4-CF.sub.3   4-F      H        iPr  S      OEt      OEt                       4-OCF.sub.3  4-F      H        iPr  S      OEt      OEt                       4-CF.sub.3   4-OCF.sub.2 H                                                                          H        iPr  S      OEt      OEt                       4-OCF.sub.3  4-OCF.sub.2 H                                                                          H        iPr  S      OEt      OEt                       4-CF.sub.3   4-Br     H        iPr  S      OEt      OEt                       4-CF.sub.3   4-Cl     4-Cl     iPr  S      OEt      OEt                       4-OCF.sub.3  4-Cl     4-Cl     iPr  S      OEt      OEt                       4-CF.sub.3   4-F      4-Cl     iPr  S      OEt      OEt                       4-OCF.sub.3  4-F      4-Cl     iPr  S      OEt      OEt                       4-CF.sub.3   4-OCF.sub.2 H                                                                          4-Cl     iPr  S      OEt      OEt                       4-OCF.sub.3  4-OCF.sub.2 H                                                                          4-Cl     iPr  S      OEt      OEt                       4-CF.sub.3   4-Cl     4-CN     iPr  S      OEt      OEt                       4-OCF.sub.3  4-Cl     4-CN     iPr4 S      OEt      OEt                       4-CF.sub.3   4-F      4-CN     iPr  S      OEt      OEt                       4-OCF.sub.3  4-F      4-CN     iPr  S      OEt      OEt                       4-CF.sub.3   4-Cl     4-CO.sub.2 Me                                                                          iPr  S      OEt      OEt                       4-CF.sub.3   4-Cl     H        iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-Cl     H        iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-F      H        iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-F      H        iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-OCF.sub.2 H                                                                          H        iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Br     H        iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-Cl         4-Cl     4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-Br         4-Cl     4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-Cl     4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.2 H                                                                              4-Cl     4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-F      4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-Br         4-F      4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-F      4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-OCF.sub.2 H                                                                          4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-OCF.sub.2 H                                                                          4-Cl     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     4-CN     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-Cl     4-CN     iPr  S      OCH C(Me) CH O                     4-CF.sub.3   4-F      4-CN     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-OCF.sub.3  4-F      4-CN     iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     4-CO.sub.2 Me                                                                          iPr  S      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  4-CF.sub.3   4-Cl     H        tBu  S      OiPr     OiPr                      4-CF.sub.3   4-F      H        tBu  S      OiPr     OiPr                      4-CF.sub.3   4-OCF.sub.2 H                                                                          H        tBu  S      OCH.sub.2 CH.sub.2 CH.sub.2 O      4-OCF.sub.3  4-OCF.sub.2 H                                                                          H        tBu  S      OCH.sub.2 CH.sub.2 CH.sub.2 O      4-CF.sub.3   4-Br     H        tBu  S      OCH.sub.2 CH.sub.2 CH.sub.2 O      4-CF.sub.3   4-Cl     4-Cl     tBu  S      OCH.sub.2 CH.sub.2 O               4-Br         4-Cl     4-Cl     tBu  S      OCH.sub.2 CH.sub.2 O               4-OCF.sub.3  4-Cl     4-Cl     tBu  S      OCH.sub.2 CH.sub.2 O               4-CF.sub.3   4-F      4-Cl     Me   S      OEt      OEt                       4-OCF.sub.3  4-F      4-Cl     Me   S      OEt      OEt                       4-CF.sub.3   4-OCF.sub.2 H                                                                          4-Cl     Me   S      OEt      OEt                       4-Cl         4-OCF.sub.2 H                                                                          4-Cl     Me   S      OEt      OEt                       4-CF.sub.3   4-F      4-CN     tBu  O      OEt      OEt                       4-OCF.sub.3  4-F      4-CN     tBu  O      OEt      OEt                        4-CF.sub.3  4-Cl     4-CO.sub.2 Me                                                                          tBu  O      OCH.sub.2 C(Me).sub.2 CH.sub.2                                                O                                  __________________________________________________________________________

                                      TABLE 19                                    __________________________________________________________________________     ##STR31##                                                                    R.sub.1           R.sub.2  R.sub.3  R.sub.8                                                                              Y.sup.1                                                                             R.sub.10                                                                            Y.sup.1 R.sub.11       __________________________________________________________________________    4-CF.sub.3        4-Cl     H        iPr    O     Et    OEt                    4-OCF.sub.3       4-Cl     H        iPr    O     Et    OEt                    4-CF.sub.3        4-F      H        iPr    O     Et    OEt                    4-OCF.sub.3       4-F      H        iPr    O     Et    OEt                    4-CF.sub.3        4-OCF.sub.2 H                                                                          H        iPr    O     Et    OEt                    4-OCF.sub.3       4-OCF.sub.2 H                                                                          H        iPr    O     Et    OEt                    4-CF.sub.3        4-Br     H        iPr    O     Et    OEt                    4-CF.sub.3        4-Cl     4-Cl     iPr    O     Et    OEt                    4-Cl              4-Cl     4-Cl     iPr    O     Et    OEt                    4-Br              4-Cl     4-Cl     iPr    O     Et    OEt                    4-OCF.sub.3       4-Cl     4-Cl     iPr    O     Et    OEt                    4-OCF.sub.2 H     4-Cl     4-Cl     iPr    O     Et    OEt                    4-CF.sub.3        4-F      4-Cl     iPr    O     Et    OEt                    4-Cl              4-F      4-Cl     iPr    O     Et    OEt                    4-Br              4-F      4-Cl     iPr    O     Et    OEt                    4-OCF.sub.3       4-F      4-Cl     iPr    O     Et    OEt                    4-CF.sub.3        4-OCF.sub.2 H                                                                          4-Cl     iPr    O     Et    OEt                    4-OCF.sub.3       4-OCF.sub.2 H                                                                          4-Cl     iPr    O     Et    OEt                    4-CF.sub.3        4-Cl     4-CN     iPr    O     Et    OEt                    4-OCF.sub.3       4-Cl     4-CN     iPr    O     Et    OEt                    4-CF.sub.3        4-F      4-CN     iPr    O     Et    OEt                    4-OCF.sub.3       4-F      4-CN     iPr    O     Et    OEt                    4-CF.sub.3        4-Cl     4-CO.sub.2 Me                                                                          iPr    O     Et    OEt                    4-CF.sub.3        4-Cl     H        iPr    O     Et    OiPr                   4-OCF.sub.3       4-Cl     H        iPr    O     Et    OiPr                   4-CF.sub.3        4-F      H        iPr    O     Et    OiPr                   4-OCF.sub.3       4-F      H        iPr    O     Et    OiPr                   4-CF.sub.3        4-OCF.sub.2 H                                                                          H        iPr    O     Et    OiPr                   4-OCF.sub.3       4-OCF.sub.2 H                                                                          H        iPr    O     Et    OPh                    4-OCF.sub.2 H     4-OCF.sub.2 H                                                                          H        iPr    O     Et    OPh                    3,4-CH.sub.2 C(Me).sub.2 O                                                                      4-OCF.sub.2 H                                                                          H        iPr    O     Et    OPh                    4-CF.sub.3        4-Br     H        iPr    O     Et    OPh                    4-CF.sub.3        4-Cl     4-Cl     iPr    O     Et    OPh                    4-Cl              4-Cl     4-Cl     iPr    O     Et    OPh                    4-Br              4-Cl     4-Cl     iPr    O     Et    OPh                    4-OCF.sub.3       4-Cl     4-Cl     iPr    O     Et    OPh                    4-OCF.sub.2 H     4-Cl     4-Cl     iPr    O     Et    OPh                    4-CF.sub.3        4-F      4-CN     tBu    O     Et    OEt                    4-OCF.sub.3       4-F      4-CN     tBu    O     Et    OEt                    4-CF.sub.3        4-Cl     4-CO.sub.2 Me                                                                          tBu    O     Et    OEt                    4-CF.sub.3        4-Cl     H        tBu    O     Et    OiPr                   4-OCF.sub.3       4-Cl     H        tBu    O     Et    OiPr                   4-CF.sub.3        4-F      H        tBu    O     Et    OiPr                   4-OCF.sub.3       4-F      H        tBu    O     Et    OiPr                   4-CF.sub.3        4-OCF.sub.2 H                                                                          H        tBu    O     Et    OiPr                   4-OCF.sub.3       4-OCF.sub.2 H                                                                          H        Ph     O     Et    OEt                    4-CF.sub.3        4-F      H        iPr    S     Et    OEt                    4-OCF.sub.3       4-F      H        iPr    S     Ph    OEt                    4-CF.sub.3        4-OCF.sub.2 H                                                                          4-Cl     tBu    S     Et    OEt                    4-OCF.sub.3       4-OCF.sub.2 H                                                                          4-Cl     tBu    S     Ph    OEt                    4-CF.sub.3        4-F      4-CN     iPr    S     iPr   OiPr                   4-OCF.sub.3       4-F      4-CN     iPr    S     nPr   OEt                    4-CF.sub.3        4-Cl     4-CO.sub.2 Me                                                                          tBu    S     Me    OEt                    __________________________________________________________________________

                                      TABLE 20                                    __________________________________________________________________________     ##STR32##                                                                           R.sub.1         R.sub.2      R.sub.3     R.sub.9                       __________________________________________________________________________           4-CF.sub.3      4-Cl         H           CF.sub.3                             4-CF.sub.3      4-F          H           CF.sub.3                             4-CF.sub.3      4-OCF.sub.2 H                                                                              H           CF.sub.3                             4-OCF.sub.3     4-OCF.sub.2 H                                                                              H           CF.sub.3                             4-CF.sub.3      4-Br         H           CF.sub.3                             4-CF.sub.3      4-Cl         4-Cl        CF.sub.3                             4-Cl            4-Cl         4-Cl        CF.sub.3                             4-Br            4-Cl         4-Cl        CF.sub.3                             4-OCF.sub.3     4-Cl         4-Cl        CF.sub.3                             4-OCF.sub.2 H   4-Cl         4-Cl        CF.sub.3                             3,4-CH.sub.2 C(Me).sub.2 O                                                                    4-Cl         4-Cl        CF.sub.3                             4-CF.sub.3      4-F          4-Cl        CF.sub.3                             4-CF.sub.3      4-OCF.sub.2 H                                                                              4-Cl        CF.sub.3                             4-CF.sub.3      4-Cl         4-CN        CF.sub.3                             4-CF.sub.3      4-F          4-CN        CF.sub.3                             4-CF.sub.3      4-Cl         4-CO.sub.2 Me                                                                             CF.sub.3                             4-CF.sub.3      4-Cl         H           O-secBu                              4-CF.sub.3      4-F          H           O-secBu                              4-CF.sub.3      4-OCF.sub.2 H                                                                              H           O-secBu                              4-Cl            4-OCF.sub.2 H                                                                              H           O-secBu                              4-OCF.sub.3     4-OCF.sub.2 H                                                                              H           O-secBu                              4-CF.sub.3      4-Br         H           O-secBu                              4-CF.sub.3      4-Cl         4-Cl        O-secBu                              4-Cl            4-Cl         4-Cl        O-secBu                              4-Br            4-Cl         4-Cl        O-secBu                              4-OCF.sub.3     4-Cl         4-Cl        O-secBu                              4-CF.sub.3      4-F          4-Cl        O-secBu                              4-Cl            4-F          4-Cl        O-secBu                              4-OCF.sub.3     4-F          4-Cl        O-secBu                              4-CF.sub.3      4-OCF.sub.2 H                                                                              4-Cl        O-secBu                              4-OCF.sub.3     4-OCF.sub.2 H                                                                              4-Cl        O-secBu                              4-CF.sub.3      4-Cl         4-CN        O-secBu                              4-CF.sub.3      4-F          4-CN        O-secBu                              4-CF.sub.3      4-Cl         4-CO.sub.2 Me                                                                             O-secBu                              4-CF.sub.3      4-Cl         H           O-n-Bu                               4-CF.sub.3      4-F          H           O-n-Bu                               4-CF.sub.3      4-OCF.sub.2 H                                                                              H           O-n-Bu                               4-Cl            4-OCF.sub.2 H                                                                              H           O-n-Bu                               4-Br            4-OCF.sub.2 H                                                                              H           O-n-Bu                               4-OCF.sub.3     4-OCF.sub.2 H                                                                              H           O-n-Bu                               4-OCF.sub.2 H   4-OCF.sub.2 H                                                                              H           O-n-Bu                               3,4-CH.sub.2 C(Me).sub.2 O                                                                    4-OCF.sub.2 H                                                                              H           O-n-Bu                               4-CF.sub.3      4-Br         H           O-n-Bu                               4-CF.sub.3      4-Cl         4-Cl        O-n-Bu                               4-Cl            4-Cl         4-Cl        O-n-Bu                               4-OCF.sub.3     4-Cl         4-Cl        O-n-Bu                               4-CF.sub.3      4-F          4-Cl        O-n-hexyl                            4-Cl            4-F          4-Cl        O-n-hexyl                            4-OCF.sub.3     4-F          4-Cl        O-n-hexyl                            4-CF.sub.3      4-OCF.sub.2 H                                                                              4-Cl        O-n-hexyl                            4-CF.sub.3      4-Cl         4-CN        O-n-hexyl                            4-CF.sub.3      4-F          4-CN        O-n-hexyl                            4-CF.sub.3      4-Cl         4-CO.sub.2 Me                                                                             O-n-hexyl                            4-CF.sub.3      4-Cl         H           OCH.sub.2 CCl.sub.3                  4-CF.sub.3      4-F          H           OCH.sub.2 CCl.sub.3                  4-CF.sub.3      4-OCF.sub.2 H                                                                              H           OCH.sub.2 CCl.sub.3                  4-Cl            4-OCF.sub.2 H                                                                              H           OCH.sub.2 CCl.sub.3                  4-OCF.sub.3     4-OCF.sub.2 H                                                                              H           OCH.sub.2 CCl.sub.3                  4-CF.sub.3      4-Br         H           OCH.sub.2 CCl.sub.3                  4-CF.sub.3      4-Cl         4-Cl        OCH.sub.2 CCl.sub.3                  4-Cl            4-Cl         4-Cl        OCH.sub.2 CCl.sub.3                  4-OCF.sub.3     4-Cl         4-Cl        OCH.sub.2 CCl.sub.3                  4-CF.sub.3      4-F          4-Cl        OCH.sub.2 CH.sub.2 OEt               4-CF.sub.3      4-OCF.sub.2 H                                                                              4-Cl        OCH.sub.2 CH.sub.2 OEt               4-CF.sub.3      4-Cl         4-CN        OCH.sub.2 CH.sub.2 OEt               4-CF.sub.3      4-F          4-CN        OCH.sub.2 CH.sub.2 OEt               4-CF.sub.3      4-Cl         4-CO.sub.2 Me                                                                             OCH.sub.2 CH.sub.2            __________________________________________________________________________                                                    OEt                       

                                      TABLE 21                                    __________________________________________________________________________     ##STR33##                                                                    R.sub.1             R.sub.2   R.sub.3    R.sub.10   R.sub.11                  __________________________________________________________________________    4-CF.sub.3          4-Cl      H          Et         Et                        4-CF.sub.3          4-F       H          Et         Et                        4-CF.sub.3          4-OCF.sub.2 H                                                                           H          Et         Et                        4-CF.sub.3          4-Br      H          Et         Et                        4-CF.sub.3          4-Cl      4-Cl       Et         Et                        4-Cl                4-Cl      4-Cl       Et         Et                        4-Br                4-Cl      4-Cl       Et         Et                        4-OCF.sub.3         4-Cl      4-Cl       Et         Et                        4-OCF.sub.2 H       4-Cl      4-Cl       Et         Et                        3,4-CH.sub.2 C(Me).sub.2 O                                                                        4-Cl      4-Cl       Et         Et                        4-CF.sub.3          4-F       4-Cl       Et         Et                        4-Cl                4-F       4-Cl       Et         Et                        4-Br                4-F       4-Cl       Et         Et                        4-OCF.sub.3         4-F       4-Cl       Et         Et                        4-OCF.sub.2 H       4-F       4-Cl       Et         Et                        3,4-CH.sub.2 C(Me).sub.2 O                                                                        4-F       4-Cl       Et         Et                        4-CF.sub.3          4-OCF.sub.2 H                                                                           4-Cl       Et         Et                        4-CF.sub.3          4-Cl      4-CN       Et         Et                        4-CF.sub.3          4-F       4-CN       Et         Et                        4-CF.sub.3          4-Cl      4-CO.sub.2 Me                                                                            Et         Et                        4-CF.sub.3          4-Cl      H          CH.sub.2 CH.sub.2                    4-CF.sub.3          4-F       H          CH.sub.2 CH.sub.2                    4-CF.sub.3          4-OCF.sub.2 H                                                                           H          CH.sub.2 CH.sub.2                    4-CF.sub.3          4-Br      H          CH.sub.2 CH.sub.2                    4-CF.sub.3          4-Cl      4-Cl       CH.sub.2 CH.sub.2                    4-Cl                4-Cl      4-Cl       CH.sub.2 CH.sub.2                    4-OCF.sub.3         4-Cl      4-Cl       CH.sub.2 CH.sub.2                    4-CF.sub.3          4-F       4-Cl       CH.sub.2 CH.sub.2 CH.sub.2           4-Cl                4-F       4-Cl       CH.sub.2 CH.sub.2 CH.sub.2           4-OCF.sub.3         4-F       4-Cl       CH.sub.2 CH.sub.2 CH.sub.2           4-CF.sub.3          4-OCF.sub.2 H                                                                           4-Cl       CH.sub.2 CH.sub.2 CH.sub.2           4-Cl                4-OCF.sub.2 H                                                                           4-Cl       CH.sub.2 CH.sub.2 CH.sub.2           4-OCF.sub.3         4-OCF.sub.2 H                                                                           4-Cl       CH.sub.2 CH.sub.2 CH.sub.2           4-CF.sub.3          4-Cl      4-CN       CH.sub.2 CH.sub.2 CH.sub.2           4-CF.sub.3          4-F       4-CN       CH.sub.2 CH.sub.2 CH.sub.2           4-CF.sub.3          4-Cl      4-CO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 CH.sub.2           4-CF.sub.3          4-Cl      H          CH.sub.2 C(Me).sub.2 CH.sub.2        4-CF.sub.3          4-F       H          CH.sub.2 C(Me).sub.2 CH.sub.2        4-CF.sub.3          4-OCF.sub.2 H                                                                           H          CH.sub.2 C(Me).sub.2 CH.sub.2        4-CF.sub.3          4-Br      H          CH.sub.2 C(Me).sub.2 CH.sub.2        4-CF.sub.3          4-Cl      4-Cl       CH.sub.2 C(Me).sub.2 CH.sub.2        4-Cl                4-Cl      4-Cl       CH.sub.2 C(Me).sub.2 CH.sub.2        4-Br                4-Cl      4-Cl       CH.sub.2 C(Me).sub.2 CH.sub.2        4-OCF.sub.3         4-Cl      4-Cl       CH.sub.2 C(Me).sub.2 CH.sub.2        4-OCF.sub.2 H       4-Cl      4-Cl       CH.sub.2 C(Me).sub.2 CH.sub.2        3,4-CH.sub.2 C(Me).sub.2 O                                                                        4-Cl      4-Cl       CH.sub.2 C(Me).sub.2 CH.sub.2        4-CF.sub.3          4-F       4-Cl       Ph         Ph                        4-CF.sub.3          4-OCF.sub.2 H                                                                           4-Cl       Ph         Ph                        4-CF.sub.3          4-Cl      4-CN       Ph         Ph                        4-CF.sub.3          4-F       4-CN       Ph         Ph                        4-CF.sub.3          4-Cl      4-CO.sub.2 Me                                                                            Ph         Ph                        __________________________________________________________________________

                                      TABLE 22                                    __________________________________________________________________________     ##STR34##                                                                    R.sub.1            R.sub.2   R.sub.3   R.sub.8  R.sub.12                      __________________________________________________________________________    4-CF.sub.3         4-Cl      H         nBu      nBu                           4-Cl               4-Cl      H         nBu      nBu                           4-OCF.sub.3        4-Cl      H         nBu      nBu                           4-CF.sub.3         4-F       H         nBu      nBu                           4-CF.sub.3         4-OCF.sub.2 H                                                                           H         nBu      nBu                           4-OCF.sub.3        4-OCF.sub.2 H                                                                           H         nBu      nBu                           4-CF.sub.3         4-Br      H         nBu      nBu                           4-CF.sub.3         4-Cl      4-Cl      nBu      nBu                           4-Cl               4-Cl      4-Cl      nBu      nBu                           4-Br               4-Cl      4-Cl      nBu      nBu                           4-OCF.sub.3        4-Cl      4-Cl      nBu      nBu                           4-CF.sub.3         4-F       4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2 CH.sub.2                      4-CF.sub.3         4-OCF.sub.2 H                                                                           4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2 CH.sub.2                      4-CF.sub.3         4-Cl      4-CN      CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2 CH.sub.2                      4-CF.sub.3         4-F       4-CN      CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2 CH.sub.2                      4-CF.sub.3         4-Cl      4-CO.sub.2 Me                                                                           CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2 CH.sub.2                      4-CF.sub.3         4-Cl      H         CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-OCF.sub.3        4-Cl      H         CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-CF.sub.3         4-F       H         CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-OCF.sub.3        4-F       H         CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-CF.sub.3         4-OCF.sub.2 H                                                                           H         CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-OCF.sub.3        4-OCF.sub.2 H                                                                           H         CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-CF.sub.3         4-Br      H         CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-CF.sub.3         4-Cl      4-Cl      CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-Cl               4-Cl      4-Cl      CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-Br               4-Cl      4-Cl      CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-OCF.sub.3        4-Cl      4-Cl      CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2                               4-CF.sub.3         4-F       4-Cl      CH.sub.2 CHMeOCHMeCH.sub.2             4-CF.sub.3         4-OCF.sub.2 H                                                                           4-Cl      CH.sub.2 CHMeOCHMeCH.sub.2             4-CF.sub.3         4-Cl      4-CN      CH.sub.2 CHMeOCHMeCH.sub.2             4-CF.sub.3         4-F       4-CN      CH.sub.2 CHMeOCHMeCH.sub.2             4-CF.sub.3         4-Cl      4-CO.sub.2 Me                                                                           CH.sub.2 CHMeOCHMeCH.sub.2             4-CF.sub.3         4-Cl      H         Et       cyclo-C.sub.6 H.sub.11        4-CF.sub.3         4-F       H         Et       cyclo-C.sub.6 H.sub.11        4-CF.sub.3         4-OCF.sub.2 H                                                                           H         Et       cyclo-C.sub.6 H.sub.11        4-CF.sub.3         4-Br      H         Et       cyclo-C.sub.6 H.sub.11        4-CF.sub.3         4-Cl      4-Cl      Et       cyclo-C.sub.6 H.sub.11        4-Cl               4-Cl      4-Cl      Et       cyclo-C.sub.6 H.sub.11        4-Br               4-Cl      4-Cl      Et       cyclo-C.sub.6 H.sub.11        4-OCF.sub.3        4-Cl      4-Cl      Et       cyclo-C.sub.6 H.sub.11        4-CF.sub.3         4-F       4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-Cl               4-F       4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-OCF.sub.3        4-F       4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-CF.sub.3         4-OCF.sub.2 H                                                                           4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-Cl               4-OCF.sub.2 H                                                                           4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-Br               4-OCF.sub.2 H                                                                           4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-OCF.sub.3        4-OCF.sub.2 H                                                                           4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-OCF.sub.2 H      4-OCF.sub.2 H                                                                           4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   3,4-CH.sub.2 C(Me).sub.2 O                                                                       4-OCF.sub.2 H                                                                           4-Cl      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-CF.sub.3         4-Cl      4-CN      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-Cl               4-Cl      4-CN      iPr      CH.sub.2 CH.sub.2                                                             CO.sub.2 ET                   4-OCF.sub.3        4-Cl      4-CN      CF.sub.3 2,4-di-ClPh                   4-CF.sub.3         4-F       4-CN      CF.sub.3 2,4-di-ClPh                   4-CF.sub.3         4-Cl      4-CO.sub.2 Me                                                                           CF.sub.3 2,4-di-ClPh                   __________________________________________________________________________

                                      TABLE 23                                    __________________________________________________________________________     ##STR35##                                                                    R.sub.1      R.sub.2 R.sub.3                                                                              R.sub.10                                          __________________________________________________________________________    4-CF.sub.3   4-Cl    H      tBu                                               4-OCF.sub.3  4-Cl    H      tBu                                               4-CF.sub.3   4-F     H      tBu                                               4-CF.sub.3   4-OCF.sub.2 H                                                                         H      tBu                                               4-OCF.sub.3  4-OCF.sub.2 H                                                                         H      tBu                                               4-CF.sub.3   4-Br    H      tBu                                               4-CF.sub.3   4-Cl    4-Cl   tBu                                               4-Cl         4-Cl    4-Cl   tBu                                               4-Br         4-Cl    4-Cl   tBu                                               4-OCF.sub.3  4-Cl    4-Cl   tBu                                               4-OCF.sub.2 H                                                                              4-Cl    4-Cl   tBu                                               4-CF.sub.3   4-F     4-Cl   tBu                                               4-CF.sub.3   4-OCF.sub.2 H                                                                         4-Cl   tBu                                               4-Cl         4-OCF.sub.2 H                                                                         4-Cl   tBu                                               4-OCF.sub.3  4-OCF.sub.2 H                                                                         4-Cl   tBu                                               4-CF.sub.3   4-Cl    4-CN   tBu                                               4-CF.sub.3   4-F     4-CN   tBu                                               4-CF.sub.3   4-Cl    4-CO.sub.2 Me                                                                        tBu                                               4-CF.sub.3   4-Cl    H      sec-Bu                                            4-OCF.sub.3  4-Cl    H      sec-Bu                                            4-CF.sub.3   4-F     H      sec-Bu                                            4-OCF.sub.3  4-F     H      sec-Bu                                            4-CF.sub.3   4-OCF.sub.2 H                                                                         H      sec-Bu                                            4-Cl         4-OCF.sub.2 H                                                                         H      sec-Bu                                            4-OCF.sub.3  4-OCF.sub.2 H                                                                         H      Ph                                                4-OCF.sub.2 H                                                                              4-OCF.sub.2 H                                                                         H      Ph                                                3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-OCF.sub.2 H                                                                         H      Ph                                                4-CF.sub.3   4-Br    H      Ph                                                4-CF.sub.3   4-Cl    4-Cl   Ph                                                4-Cl         4-Cl    4-Cl   Ph                                                4-Br         4-Cl    4-Cl   Ph                                                4-OCF.sub.3  4-Cl    4-Cl   Ph                                                4-OCF.sub.2 H                                                                              4-Cl    4-Cl   Ph                                                3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-Cl    4-Cl   Ph                                                4-CF.sub.3   4-F     4-Cl   4-ClPh                                            4-Cl         4-F     4-Cl   4-ClPh                                            4-Br         4-F     4-Cl   4-ClPh                                            4-OCF.sub.3  4-F     4-Cl   4-ClPh                                            4-OCF.sub.2 H                                                                              4-F     4-Cl   4-ClPh                                            3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-F     4-Cl   4-ClPh                                            4-CF.sub.3   4-OCF.sub.2 H                                                                         4-Cl   4-ClPh                                            4-CF.sub.3   4-Cl    4-CN   4-ClPh                                            4-OCF.sub.3  4-Cl    4-CN   2-Me-4-t-BuPh                                     4-CF.sub.3   4-F     4-CN   2-Me-4-t-BuPh                                     4-OCF.sub.3  4-F     4-CN   2-Me-4-t-BuPh                                     4-CF.sub.3   4-Cl    4-CO.sub.2 Me                                                                        2-Me-4-t-BuPh                                     4-CF.sub.3   4-Cl    H      2-NO.sub.2Ph                                      4-OCF.sub.3  4-Cl    H      2-NO.sub.2Ph                                      4-CF.sub.3   4-F     H      2-NO.sub.2Ph                                      4-CF.sub.3   4-OCF.sub.2 H                                                                         H      2-NO.sub.2Ph                                      4-OCF.sub.3  4-OCF.sub.2 H                                                                         H      2-NO.sub.2Ph                                      4-CF.sub.3   4-Br    H      2-NO.sub.2Ph                                      4-CF.sub.3   4-Cl    4-Cl   2-NO.sub.2Ph                                      4-Cl         4-Cl    4-Cl   2-NO.sub.2Ph                                      4-Br         4-Cl    4-Cl   2-NO.sub.2Ph                                      4-OCF.sub.3  4-Cl    4-Cl   2-NO.sub.2Ph                                      4-CF.sub.3   4-F     4-Cl   2-NO.sub.2 Ph                                     4-Cl         4-F     4-Cl   2-NO.sub.2 Ph                                     4-OCF.sub.3  4-F     4-Cl   2-NO.sub.2 Ph                                     4-CF.sub.3   4-OCF.sub.2 H                                                                         4-Cl   2-NO.sub.2 Ph                                     4-OCF.sub.3  4-OCF.sub.2 H                                                                         4-Cl   2-NO.sub.2 Ph                                     4-CF.sub.3   4-Cl    4-CN   2-NO.sub.2 Ph                                     4-OCF.sub.3  4-Cl    4-CN   2-NO.sub.2 Ph                                     4-CF.sub.3   4-F     4-CN   2-NO.sub.2 Ph                                     4-CF.sub.3   4-Cl    4-CO.sub.2 Me                                                                        2-NO.sub.2 Ph                                     __________________________________________________________________________

                                      TABLE 24                                    __________________________________________________________________________     ##STR36##                                                                    R.sub.1     R.sub.2  R.sub.3                                                                             Z                                                  __________________________________________________________________________    4-CF.sub.3  4-H      4-H   CH.sub.3                                           4-CF.sub.3  4-H      4-Cl  CH.sub.3                                           4-CF.sub.3  4-H      4-F   CH.sub.3                                           4-CF.sub.3  4-F      4-H   CH.sub.3                                           4-CF.sub.3  4-F      4-Cl  CH.sub.3                                           4-CF.sub.3  4-F      4-F   CH.sub.3                                           4-CF.sub.3  4-Cl     4-H   CH.sub.3                                           4-CF.sub.3  4-Cl     4-Cl  CH.sub.3                                           4-CF.sub.3  4-Cl     4-F   CH.sub.3                                           4-CF.sub.3  4-OCHF.sub.2                                                                           4-H   CH.sub.3                                           4-CF.sub.3  4-OCHF.sub.2                                                                           4-Cl  CH.sub.3                                           4-CF.sub.3  4-OCHF.sub.2                                                                           4-F   CH.sub.3                                           4-OCF.sub.3 4-H      4-H   CH.sub.3                                           4-OCF.sub.3 4-H      4-Cl  CH.sub.3                                           4-OCF.sub.3 4-H      4-F   CH.sub.3                                           4-OCF.sub.3 4-F      4-H   CH.sub.3                                           4-OCF.sub.3 4-F      4-Cl  CH.sub.3                                           4-OCF.sub.3 4-F      4-F   CH.sub.3                                           4-OCF.sub.3 4-Cl     4-H   CH.sub.3                                           4-OCF.sub.3 4-Cl     4-Cl  CH.sub.3                                           4-OCF.sub.3 4-Cl     4-F   CH.sub.3                                           4-Cl        4-H      4-H   CH.sub.3                                           4-Cl        4-H      4-Cl  CH.sub.3                                           4-Cl        4-H      4-F   CH.sub.3                                           4-Cl        4-Cl     4-H   CH.sub.3                                           4-Cl        4-Cl     4-Cl  CH.sub.3                                           4-Cl        4-Cl     4-F   CH.sub.3                                           4-Cl        4-F      4-H   CH.sub.3                                           4-Cl        4-F      4-Cl  CH.sub.3                                           4-Cl        4-F      4-F   CH.sub.3                                           4-Br        4-H      4-H   CH.sub.3                                           4-Br        4-H      4-F   CH.sub.3                                           4-Br        4-H      4-Cl  CH.sub.3                                           4-Br        4-Cl     4-H   CH.sub.3                                           4-Br        4-Cl     4-F   CH.sub.3                                           4-Br        4-Cl     4-Cl  CH.sub.3                                           4-Br        4-F      4-H   CH.sub.3                                           4-Br        4-F      4-F   CH.sub.3                                           4-Br        4-F      4-Cl  CH.sub.3                                           4-OCHF.sub.2                                                                              4-H      4-H   CH.sub.3                                           4-OCHF.sub.2                                                                              4-H      4-F   CH.sub.3                                           4-OCHF.sub.2                                                                              4-H      4-Cl  CH.sub.3                                           4-OCHF.sub.2                                                                              4-F      4-H   CH.sub.3                                           4-OCHF.sub.2                                                                              4-F      4-F   CH.sub.3                                           4-OCHF.sub.2                                                                              4-F      4-Cl  CH.sub.3                                           4-OCHF.sub.2                                                                              4-Cl     4-H   CH.sub.3                                           4-OCHF.sub.2                                                                              4-Cl     4-F   CH.sub.3                                           4-OCHF.sub.2                                                                              4-Cl     4-Cl  CH.sub.3                                           4-CF.sub.3  4-H      4-H   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-H      4-Cl  CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-H      4-F   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-F      4-H   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-F      4-Cl  CH.sub.3 CH.sub.2                                  4-CF.sub. 3 4-F      4-F   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-Cl     4-H   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-Cl     4-F   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-OCHF.sub.2                                                                           4-H   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-OCHF.sub.2                                                                           4-Cl  CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-OCHF.sub.2                                                                           4-F   CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-H      4-H   CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-H      4-Cl  CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-H      4-F   CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-F      4-H   CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-F      4-Cl  CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-F      4-F   CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-Cl     4-H   CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-Cl     4-Cl  CH.sub.3 CH.sub.2                                  4-OCF.sub.3 4-Cl     4-F   CH.sub.3 CH.sub.2                                  4-Cl        4-H      4-H   CH.sub.3 CH.sub.2                                  4-Cl        4-H      4-Cl  CH.sub.3 CH.sub.2                                  4-Cl        4-H      4-F   CH.sub.3 CH.sub.2                                  4-Cl        4-Cl     4-H   CH.sub.3 CH.sub.2                                  4-Cl        4-Cl     4-Cl  CH.sub.3 CH.sub.2                                  4-Cl        4-Cl     4-F   CH.sub.3 CH.sub.2                                  4-Cl        4-F      4-H   CH.sub.3 CH.sub.2                                  4-Cl        4-F      4-Cl  CH.sub.3 CH.sub.2                                  4-Cl        4-F      4-F   CH.sub.3 CH.sub.2                                  4-CF.sub.3  4-H      4-H   C.sub.6 H.sub. 5                                   4-CF.sub.3  4-H      4-Cl  C.sub.6 H.sub.5                                    4-CF.sub.3  4-H      4-F   C.sub.6 H.sub.5                                    4-CF.sub.3  4-F      4-H   C.sub.6 H.sub.5                                    4-CF.sub.3  4-F      4-Cl  C.sub.6 H.sub.5                                    4-CF.sub.3  4-F      4-F   C.sub.6 H.sub.5                                    4-CF.sub.3  4-Cl     4-H   C.sub.6 H.sub.5                                    4-CF.sub.3  4-Cl     4-Cl  C.sub.6 H.sub.5                                    4-CF.sub.3  4-Cl     4-F   C.sub.6 H.sub.5                                    4-CF.sub.3  4-OCHF.sub.2                                                                           4-H   C.sub.6 H.sub.5                                    4-CF.sub.3  4-OCHF.sub.2                                                                           4-Cl  C.sub.6 H.sub.5                                    4-CF.sub.3  4-OCHF.sub.2                                                                           4-F   C.sub.6 H.sub.5                                    4-OCF.sub.3 4-H      4-H   C.sub.6 H.sub.5                                    4-OCF.sub.3 4-H      4-Cl  C.sub.6 H.sub.5                                    4-OCF.sub.3 4-H      4-F   C.sub.6 H.sub.5                                    4-OCF.sub.3 4-F      4-H   C.sub.6 H.sub.5                                    4-OCF.sub.3 4-F      4-Cl  C.sub.6 H.sub.5                                    4-OCF.sub.3 4-F      4-F   C.sub.6 H.sub.5                                    4-OCF.sub.3 4-Cl     4-H   C.sub.6 H.sub.5                                    4-OCF.sub.3 4-Cl     4-Cl  C.sub.6 H.sub.5                                    4-OCF.sub.3 4-Cl     4-F   C.sub.6 H.sub.5                                    4-Cl        4-H      4-H   C.sub.6 H.sub.5                                    4-Cl        4-H      4-Cl  C.sub.6 H.sub.5                                    4-Cl        4-H      4-F   C.sub.6 H.sub.5                                    4-Cl        4-F      4-H   C.sub.6 H.sub.5                                    4-Cl        4-F      4-Cl  C.sub.6 H.sub.5                                    4-Cl        4-F      4-F   C.sub.6 H.sub.5                                    4-CF.sub.3  4-H      4-H   CH.sub.3 O                                         4-CF.sub.3  4-H      4-Cl  CH.sub.3 O                                         4-CF.sub.3  4-H      4-F   CH.sub.3 O                                         4-CF.sub.3  4-F      4-H   CH.sub.3 O                                         4-CF.sub.3  4-F      4-Cl  CH.sub.3 O                                         4-CF.sub.3  4-F      4-F   CH.sub.3 O                                         4-CF.sub.3  4-Cl     4-H   CH.sub.3 O                                         4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 O                                         4-CF.sub.3  4-Cl     4-F   CH.sub.3 O                                         4-CF.sub.3  4-OCHF.sub.2                                                                           4-H   CH.sub.3 O                                         4-CF.sub.3  4-OCHF.sub.2                                                                           4-Cl  CH.sub.3 O                                         4-CF.sub.3  4-OCHF.sub.2                                                                           4-F   CH.sub.3 O                                         4-OCF.sub.3 4-H      4-H   CH.sub.3 O                                         4-OCF.sub.3 4-H      4-Cl  CH.sub.3 O                                         4-OCF.sub.3 4-H      4-F   CH.sub.3 O                                         4-OCF.sub.3 4-F      4-H   CH.sub.3 O                                         4-OCF.sub.3 4-F      4-Cl  CH.sub.3 O                                         4-OCF.sub.3 4-F      4-F   CH.sub.3 O                                         4-OCF.sub.3 4-Cl     4-H   CH.sub.3 O                                         4-OCF.sub.3 4-Cl     4-Cl  CH.sub.3 O                                         4-OCF.sub.3 4-Cl     4-F   CH.sub.3 O                                         4-Cl        4-H      4-H   CH.sub.3 O                                         4-Cl        4-H      4-Cl  CH.sub.3 O                                         4-Cl        4-H      4-F   CH.sub.3 O                                         4-Cl        4-Cl     4-H   CH.sub.3 O                                         4-Cl        4-Cl     4-Cl  CH.sub.3 O                                         4-Cl        4-Cl     4-F   CH.sub.3 O                                         4-Cl        4-F      4-H   CH.sub.3 O                                         4-Cl        4-F      4-Cl  CH.sub.3 O                                         4-Cl        4-F      4-F   CH.sub.3 O                                         4-CF.sub.3  4-H      4-H   H                                                  4-CF.sub.3  4-H      4-Cl  H                                                  4-CF.sub.3  4-H      4-F   H                                                  4-CF.sub.3  4-F      4-H   H                                                  4-CF.sub.3  4-F      4-Cl  H                                                  4-CF.sub.3  4-F      4-F   H                                                  4-CF.sub.3  4-Cl     4-H   H                                                  4-CF.sub.3  4-Cl     4-Cl  H                                                  4-CF.sub.3  4-Cl     4-F   H                                                  4-CF.sub.3  4-OCHF.sub.2                                                                           4-H   H                                                  4-CF.sub.3  4-OCHF.sub.2                                                                           4-Cl  H                                                  4-CF.sub.3  4-OCHF.sub.2                                                                           4-F   H                                                  4-OCF.sub.3 4-H      4-H   H                                                  4-OCF.sub.3 4-H      4-Cl  H                                                  4-OCF.sub.3 4-H      4-F   H                                                  4-OCF.sub.3 4-F      4-H   H                                                  4-OCF.sub.3 4-F      4-Cl  H                                                  4-OCF.sub.3 4-F      4-F   H                                                  4-OCF.sub.3 4-Cl     4-H   H                                                  4-OCF.sub.3 4-Cl     4-Cl  H                                                  4-OCF.sub.3 4-Cl     4-F   H                                                  4-Cl        4-H      4-H   H                                                  4-Cl        4-H      4-Cl  H                                                  4-Cl        4-H      4-F   H                                                  4-Cl        4-Cl     4-H   H                                                  4-Cl        4-Cl     4-Cl  H                                                  4-Cl        4-Cl     4-F   H                                                  4-Cl        4-F      4-H   H                                                  4-Cl        4-F      4-Cl  H                                                  4-Cl        4-F      4-F   H                                                  4-CF.sub.3  4-Cl     4-Cl  BrCH.sub.2                                         4-CF.sub.3  4-Cl     4-Cl  ClCH.sub.2                                         4-CF.sub.3  4-Cl     4-Cl  CF.sub.3                                           4-CF.sub.3  4-Cl     4-Cl  benzyl                                             4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 CH.sub.2 CH.sub.2                         4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.3                          4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.4                          4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.5                          4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.6                          4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.7                          4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.9                          4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.10                         4-CF.sub.3  4-Cl     4-Cl  Cl.sub.3 C                                         4-CF.sub.3  4-Cl     4-Cl  i-Pr                                               4-CF.sub.3  4-Cl     4-Cl  t-Bu                                               4-CF.sub.3  4-Cl     4-Cl  MeO.sub.2 C                                        4-CF.sub.3  4-Cl     4-Cl  EtO.sub.2 C                                        4-CF.sub.3  4-Cl     4-Cl  2-Cl-phenyl                                        4-CF.sub.3  4-Cl     4-Cl  3-Cl-phenyl                                        4-CF.sub.3  4-Cl     4-Cl  4-Cl-phenyl                                        4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 CH2O                                      4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.2 O                        4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.4 O                        4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.6 O                        4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.8 O                        4-CF.sub.3  4-Cl     4-Cl  CH.sub.3 (CH.sub.2).sub.10 O                       4-CF.sub.3  4-Cl     4-Cl  phenyl-O                                           4-CF.sub.3  4-Cl     4-Cl  4-Cl-phenyl-O                                      4-CF.sub.3  4-Cl     4-Cl  benzyl-O                                           4-Cl        4-Cl     4-Cl  ClCH.sub.2                                         4-Cl        4-Cl     4-Cl  CF.sub.3                                           4-Cl        4-Cl     4-Cl  benzyl                                             4-Cl        4-Cl     4-Cl  CH.sub.3 (CH.sub. 2).sub.3                         4-Cl        4-Cl     4-Cl  CH.sub.3 O.sub.2 C                                 4-Cl        4-Cl     4-Cl  CH.sub.3 CH.sub.2 O                                __________________________________________________________________________

                                      TABLE 25                                    __________________________________________________________________________     ##STR37##                                                                    R.sub.1  R.sub.2                                                                             R.sub.3 R.sub.8                                                                            R.sub.9                                           __________________________________________________________________________    4-CF.sub.3                                                                             4-Cl  H       Me   O-nBu                                             4-OCF.sub.3                                                                            4-Cl  H       Me   O-nBu                                             4-CF.sub.3                                                                             4-F   H       Me   O-nBu                                             4-OCF.sub.3                                                                            4-F   H       Me   O-nBu                                             4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       H       Me   O-nBu                                             4-CF.sub.3                                                                             4-Br  H       Me   O-nBu                                             4-CF.sub.3                                                                             4-Cl  4-Cl    Me   O-nBu                                             4-Cl     4-Cl  4-Cl    Me   O-nBu                                             4-Br     4-Cl  4-Cl    Me   O-nBu                                             4-OCF.sub.3                                                                            4-Cl  4-Cl    Me   O-nBu                                             4-CF.sub.3                                                                             4-F   4-Cl    Me   O-nBu                                             4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       4-Cl    Me   O-nBu                                             4-CF.sub.3                                                                             4-Cl  4-CN    Me   O-nBu                                             4-CF.sub.3                                                                             4-F   4-CN    Me   O-nBu                                             4-CF.sub.3                                                                             4-Cl  4-CO.sub.2 Me                                                                         Me   O-nBu                                             4-CF.sub.3                                                                             4-Cl  H       Me   O-n-hexyl                                         4-CF.sub.3                                                                             4-F   H       Me   O-n-hexyl                                         4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       H       Me   O-n-octyl                                         4-CF.sub.3                                                                             4-Br  H       Me   O-n-decyl                                         4-CF.sub.3                                                                             4-Cl  4-Cl    Me   O-n-dodecyl                                       4-Cl     4-Cl  4-Cl    Me   O-n-dodecyl                                       4-Br     4-Cl  4-Cl    Me   O-n-dodecyl                                       4-OCF.sub.3                                                                            4-Cl  4-Cl    Me   O-n-dodecyl                                       4-CF.sub.3                                                                             4-F   4-Cl    Me   O-sec-Bu                                          4-Cl     4-F   4-Cl    Me   O-sec-Bu                                          4-Br     4-F   4-Cl    Me   O-sec-Bu                                          4-OCF.sub.3                                                                            4-F   4-Cl    Me   O-sec-Bu                                          4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       4-Cl    Me   O-sec-Bu                                          4-CF.sub.3                                                                             4-Cl  4-CN    Me   O-iPr                                             4-CF.sub.3                                                                             4-F   4-CN    Me   OCH.sub.2 CH.sub.2 OEt                            4-CF.sub.3                                                                             4-Cl  4-CO.sub.2 Me                                                                         Me   OCH.sub.2 CF.sub.3                                4-CF.sub.3                                                                             4-Cl  H       Me   F                                                 4-CF.sub.3                                                                             4-F   H       Me   NMe.sub.2                                         4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       H       Me   NEt.sub.2                                         4-CF.sub.3                                                                             4-Br  H       Me   morpholino                                        4-OCF.sub.3                                                                            4-Br  H       Me   n-Pr                                              4-CF.sub.3                                                                             4-Cl  4-Cl    Me   sec-Bu                                            4-Br     4-Cl  4-Cl    Me   Ph                                                4-OCF.sub.3                                                                            4-Cl  4-Cl    Me   Ph                                                4-CF.sub.3                                                                             4-F   4-Cl    Et   O-iPr                                             4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       4-Cl    Et   O-iPr                                             4-CF.sub.3                                                                             4-Cl  4-CN    Et   OCH.sub.2 CCl.sub.3                               4-OCF.sub.3                                                                            4-Cl  4-CN    Et   NEt.sub.2                                         4-CF.sub.3                                                                             4-F   4-CN    Et   2,6-di-Me-morpholino                              4-Cl     4-F   4-CN    Et   2,6-di-Me-morpholino                              4-CF.sub.3                                                                             4-Cl  4-CO.sub.2 Me                                                                         Et   Ph                                                4-CF.sub.3                                                                             4-Cl  H       iPr  OEt                                               4-CF.sub.3                                                                             4-F   H       iPr  OEt                                               4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       H       iPr  OEt                                               4-Cl     4-OCF.sub.2 H                                                                       H       iPr  OEt                                               4-Br     4-OCF.sub.2 H                                                                       H       iPr  OEt                                               4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                       H       iPr  OEt                                               4-OCF.sub.2 H                                                                          4-OCF.sub.2 H                                                                       H       iPr  OEt                                               3,4-CH.sub.2 C(Me).sub.2 O                                                             4-OCF.sub.2 H                                                                       H       iPr  OEt                                               4-CF.sub.3                                                                             4-Br  H       iPr  OEt                                               4-CF.sub.3                                                                             4-Cl  4-Cl    iPr  OEt                                               4-OCF.sub.3                                                                            4-Cl  4-Cl    iPr  OEt                                               4-CF.sub.3                                                                             4-F   4-Cl    iPr  OEt                                               4-OCF.sub.3                                                                            4-F   4-Cl    iPr  OEt                                               4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       4-Cl    iPr  OEt                                               4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                       4-Cl    iPr  OEt                                               4-CF.sub.3                                                                             4-Cl  4-CN    iPr  OEt                                               4-OCF.sub.3                                                                            4-Cl  4-CN    iPr  OEt                                               4-CF.sub.3                                                                             4-F   4-CN    iPr  OEt                                               4-CF.sub.3                                                                             4-Cl  4-CO.sub.2 Me                                                                         iPr  OEt                                               4-OCF.sub.3                                                                            4-Cl  4-CO.sub.2 Me                                                                         iPr  OEt                                               4-CF.sub.3                                                                             4-OMe 4-Cl    iPr  OEt                                               4-Cl     4-OPh 4-Cl    iPr  OEt                                               4-Br     4-SCF.sub.2 H                                                                       4-Cl    iPr  OEt                                               4-OCF.sub.3                                                                            4-NO.sub.2                                                                          4-Cl    iPr  OEt                                               4-OCF.sub.2 H                                                                          4-SMe 4-Cl    iPr  OEt                                               3,4-CH.sub.2 C(Me).sub.2 O                                                             4-SO.sub.2 Me                                                                       4-Cl    iPr  OEt                                               4-CF.sub.3                                                                             4-CN  4-Cl    iPr  OEt                                               4-Cl     3-Cl  4-Cl    iPr  OEt                                               4-Br     3-F   4-Cl    iPr  OEt                                               4-OCF.sub.3                                                                            4-Me  4-Cl    iPr  OEt                                               4-OCF.sub.2 H                                                                          4-O-allyl                                                                           4-Cl    iPr  OEt                                               3,4-CH.sub.2 C(Me).sub.2 O                                                             4-CF.sub.3                                                                          4-Cl    iPr  OEt                                               4-CF.sub.3                                                                             4-Cl  4-CO.sub.2 Et                                                                         iPr  OEt                                               4-Cl     4-Cl  4-OMe   iPr  OEt                                               4-Br     4-Cl  4-SCF.sub.2 CF.sub.2 H                                                                iPr  OEt                                               4-OCF.sub.3                                                                            4-Cl  4-OCF.sub.2 CF.sub.2 H                                                                iPr  OEt                                               4-CF.sub.3                                                                             4-Cl  4-CF.sub.3                                                                            iPr  OEt                                               4-Cl     4-Cl  4-Me    iPr  OEt                                               4-Br     4-Cl  3-Cl    iPr  OEt                                               4-OCF.sub.3                                                                            4-Cl  3-Br    iPr  OEt                                               4-OCF.sub.2 H                                                                          4-Cl  4-NO.sub.2                                                                            iPr  OEt                                               4-CF.sub.3                                                                             4-Cl  H       iPr  O-n-Bu                                            4-CF.sub.3                                                                             4-F   H       iPr  O-n-Bu                                            4-OCF.sub.3                                                                            4-F   H       iPr  OCH.sub.2 CO.sub.2 Me                             4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       H       iPr  NMe.sub.2                                         4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                       H       iPr  piperidino                                        3,4-CH.sub.2 C(Me).sub.2 O                                                             4-OCF.sub.2 H                                                                       H       iPr  Et                                                4-CF.sub.3                                                                             4-Br  H       iPr  Et                                                4-OCF.sub.3                                                                            4-Br  H       CH.sub.2 Ph                                                                        OEt                                               4-CF.sub.3                                                                             4-Cl  4-CO.sub.2 Me                                                                         CH.sub.2 Ph                                                                        NME.sub.2                                         __________________________________________________________________________

                                      TABLE 26                                    __________________________________________________________________________     ##STR38##                                                                    R.sub.1         R.sub.2      R.sub.3   R.sub.8   R.sub.9                      __________________________________________________________________________    4-CF.sub.3      4-Cl         H         Me        NMe.sub.2                    4-CF.sub.3      4-F          H         Me        NEt.sub.2                    4-CF.sub.3      4-OCF.sub.2 H                                                                              H         Me        n-hexyl                      4-OCF.sub.3     4-OCF.sub.2 H                                                                              H         Me        Ph                           4-CF.sub.3      4-Br         H         Me        4-MePh                       4-CF.sub.3      4-Cl         4-Cl      Et        morpholino                   4-Cl            4-Cl         4-Cl      Et        iPr                          4-Br            4-Cl         4-Cl      Et        n-Bu                         4-OCF.sub.3     4-Cl         4-Cl      Et        Ph                           4-CF.sub.3      4-F          4-Cl      iPr       NMe.sub.2                    4-CF.sub.3      4-OCF.sub.2 H                                                                              4-Cl      iPr       piperidino                   4-Cl            4-OCF.sub.2 H                                                                              4-Cl      iPr       Et                           4-Br            4-OCF.sub.2 H                                                                              4-Cl      iPr       n-Bu                         4-OCF.sub.3     4-OCF.sub.2 H                                                                              4-Cl      iPr       Ph                           4-OCF.sub.2 H   4-OCF.sub. 2 H                                                                             4-Cl      iPr       4-ClPh                       __________________________________________________________________________

                                      TABLE 27                                    __________________________________________________________________________     ##STR39##                                                                    R.sub.1  R.sub.2                                                                             R.sub.3                                                                             R.sub.8 Y.sup.1                                                                     Y.sup.1 R.sub.10                                                                    Y.sup.1 R.sub.11                             __________________________________________________________________________    4-CF.sub.3                                                                             4-Cl  H     tBu S OEt   OEt                                          4-Cl     4-Cl  H     tBu S OEt   OEt                                          4-Br     4-Cl  H     tBu S OEt   OEt                                          4-OCF.sub.3                                                                            4-Cl  H     tBu S OEt   OEt                                          4-OCF.sub.2 H                                                                          4-Cl  H     tBu S OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                             4-Cl  H     tBu S OEt   OEt                                          4-CF.sub.3                                                                             4-F   H     tBu S OEt   OEt                                          4-Cl     4-F   H     tBu S OEt   OEt                                          4-Br     4-F   H     tBu S OEt   OEt                                          4-OCF    4-F   H     tBu S OCH.sub. 2 C(Me).sub.2 CH.sub.2 O                  4-OCF.sub.2 H                                                                          4-F   H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                             4-F   H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Cl     4-OCF.sub.2 H                                                                       H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Br     4-OCF.sub.2 H                                                                       H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                       H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.2 H                                                                          4-OCF.sub.2 H                                                                       H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                             4-OCF.sub.2 H                                                                       H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-CF.sub.3                                                                             4-Br  H     tBu S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Cl     4-Br  H     iPrS  OEt   OEt                                          4-Br     4-Br  H     iPrS  OEt   OEt                                          4-OCF.sub.3                                                                            4-Br  H     iPrS  OEt   OEt                                          4-OCF.sub.2 H                                                                          4-Br  H     iPrS  OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                             4-Br  H     iPrS  OEt   OEt                                          4-CF.sub.3                                                                             4-Cl  4-Cl  iPrS  OEt   OEt                                          4-Cl     4-Cl  4-Cl  iPrS  OEt   OEt                                          4-Br     4-Cl  4-Cl  iPrS  OEt   OEt                                          4-OCF.sub.3                                                                            4-Cl  4-Cl  iPrS  OEt   OEt                                          4-OCF.sub.2 H                                                                          4-Cl  4-Cl  iPrS  OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                             4-Cl  4-Cl  iPrS  OEt   OEt                                          4-CF.sub.3                                                                             4-F   4-Cl  iPrS  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Cl     4-F   4-Cl  iPrS  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Br     4-F   4-Cl  iPrS  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.3                                                                            4-F   4-Cl  iPrS  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.2 H                                                                          4-F   4-Cl  iPrS  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                             4-F   4-Cl  iPrS  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                       4-Cl  tBu S OiPr  OiPr                                         4-Cl     4-OCF.sub.2 H                                                                       4-Cl  tBu S OiPr  OiPr                                         4-Br     4-OCF.sub.2 H                                                                       4-Cl  tBu S OiPr  OiPr                                         4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                       4-Cl  tBu S OiPr  OiPr                                         4-OCF.sub.2 H                                                                          4-OCF.sub.2 H                                                                       4-Cl  tBu S OiPr  OiPr                                         3,4-CH.sub.2 C(Me).sub.2 O                                                             4-OCF.sub.2 H                                                                       4-Cl  tBu S OiPr  OiPr                                         4-CF.sub.3                                                                             4-Cl  4-CN   tBu S                                                                              OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-Cl     4-Cl  4-CN  tBu S OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-Br     4-Cl  4-CN  tBu S OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-OCF.sub.3                                                                            4-Cl  4-CN  tBu S OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-OCF.sub.2 H                                                                          4-Cl  4-CN  tBu S OCH.sub.2 CH.sub.2 CH.sub.2 O                      3,4-CH.sub.2 C(Me).sub.2 O                                                             4-Cl  4-CN  tBu S OCH.sub.2 CH.sub.2 O                               4-CF.sub.3                                                                             4-F   4-CN  tBu S OCH.sub.2 CH.sub.2 O                               4-Cl     4-F   4-CN  tBu S OCH.sub.2 CH.sub.2 O                               4-Br     4-F   4-CN  tBu S OCH.sub.2 CH.sub.2 O                               4-OCF.sub.3                                                                            4-F   4-CN  MeS   OEt   OEt                                          4-OCF.sub.2 H                                                                          4-F   4-CN  MeS   OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                             4-F   4-CN  MeS   OEt   OEt                                          4-Br     4-Cl  4-CO.sub.2 Me                                                                       tBu O OEt   OEt                                          4-OCF.sub.3                                                                            4-Cl  4-CO.sub.2 Me                                                                       tBu O OEt   OEt                                          4-OCF.sub.2 H                                                                          4-Cl  4-CO.sub.2 Me                                                                       tBu O OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                             4-Cl  4-CO.sub.2 Me                                                                       tBu O OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   __________________________________________________________________________

                                      TABLE 28                                    __________________________________________________________________________     ##STR40##                                                                    R.sub.1                                                                             R.sub.2                                                                              R.sub.3                                                                             R.sub.8                                                                            Y.sup.1                                                                           R.sub.10                                                                           Y.sup.1 R.sub.11                             __________________________________________________________________________    4-CF.sub.3                                                                          4-Cl   H     iPr  O   Et   OEt                                          4-Cl  4-Cl   H     iPr  O   Et   OEt                                          4-OCF.sub.3                                                                         4-Cl   H     iPr  O   Et   OEt                                          4-CF.sub.3                                                                          4-F    H     iPr  O   Et   O-iPr                                        4-OCF 4-F    H     iPr  O   Et   O-iPr                                        4-CF.sub.3                                                                          4-OCF.sub.2 H                                                                        H     iPr  O   Et   O-iPr                                        4-OCF.sub.3                                                                         4-OCF.sub.2 H                                                                        H     iPr  O   Et   OPh                                          4-CF.sub.3                                                                          4-Br   H     iPr  O   Et   OPh                                          4-CF.sub.3                                                                          4-Cl   4-Cl  iPr  O   Ph   OEt                                          4-Cl  4-Cl   4-Cl  iPr  O   Ph   OEt                                          4-Br  4-Cl   4-Cl  iPr  O   Ph   OEt                                          4-OCF.sub.3                                                                         4-Cl   4-Cl  iPr  O   Ph   OEt                                          4-CF.sub.3                                                                          4-F    4-Cl  tBu  O   Et   OEt                                          4-OCF.sub.3                                                                         4-F    4-Cl  tBu  O   Et   OEt                                          4-CF.sub.3                                                                          4-OCF.sub.2 H                                                                        4-Cl  tBu  O   Et   O-iPr                                        4-OCF.sub.3                                                                         4-OCF.sub.2 H                                                                        4-Cl  tBu  O   Et   O-iPr                                        4-CF.sub.3                                                                          4-Cl   4-CN  Ph   O   Et   OEt                                          4-OCF.sub.3                                                                         4-Cl   4-CN  Ph   O   Et   OEt                                          4-CF.sub.3                                                                          4-F    4-CN  iPr  S   Ph   O-iPr                                        4-OCF.sub.3                                                                         4-F    4-CN  tBu  S   Et   OEt                                          __________________________________________________________________________

                  TABLE 29                                                        ______________________________________                                         ##STR41##                                                                    R.sub.1   R.sub.2    R.sub.3   R.sub.9                                        ______________________________________                                        4-CF.sub.3                                                                              4-Cl       H         CF.sub.3                                       4-CF.sub.3                                                                              4-F        H         CF.sub.3                                       4-OCF.sub.3                                                                             4-F        H         O-sec-Bu                                       4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                            H         O-sec-Bu                                       4-Br      4-OCF.sub.2 H                                                                            H         O-sec-Bu                                       4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                            H         O-sec-Bu                                       4-CF.sub.3                                                                              4-Br       H         O-n-Bu                                         4-CF.sub.3                                                                              4-Cl       4-Cl      O-n-Bu                                         4-Cl      4-Cl       4-Cl      O-n-Bu                                         4-Br      4-Cl       4-Cl      O-n-Bu                                         4-OCF.sub.3                                                                             4-Cl       4-Cl      O-n-Bu                                         4-CF.sub.3                                                                              4-F        4-Cl      O-n-hexyl                                      4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                            4-Cl      O-n-hexyl                                      4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                            4-Cl      O-n-hexyl                                      4-CF.sub.3                                                                              4-Cl       4-CN      OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                             4-Cl       4-CN      OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                              4-F        4-CN      OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                              4-Cl       4-CO.sub.2 Me                                                                           OCH.sub.2 CH.sub.2 OEt                         ______________________________________                                    

                  TABLE 30                                                        ______________________________________                                         ##STR42##                                                                    R.sub.1 R.sub.2   R.sub.3   R.sub.10                                                                              R.sub.11                                  ______________________________________                                        4-CF.sub.3                                                                            4-Cl      H         Et      Et                                        4-CF.sub.3                                                                            4-F       H         Et      Et                                        4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           H         Et      Et                                        4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           H         CH.sub.2 CH.sub.2                                 4-CF.sub.3                                                                            4-Br      H         CH.sub.2 CH.sub.2                                 4-CF.sub.3                                                                            4-Cl      4-Cl      CH.sub.2 CH.sub.2                                 4-Cl    4-Cl      4-Cl      CH.sub.2 CH.sub.2                                 4-OCF.sub.3                                                                           4-Cl      4-Cl      CH.sub.2 CH.sub.2                                 4-CF.sub.3                                                                            4-F       4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                        4-OCF.sub.3                                                                           4-F       4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                        4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                        4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           4-Cl      CH.sub.2 C(Me).sub.2 CH.sub.2                     4-CF.sub.3                                                                            4-Cl      4-CN      CH.sub.2 C(Me).sub.2 CH.sub.2                     4-OCF.sub.3                                                                           4-Cl      4-CN      CH.sub.2 C(Me).sub.2 CH.sub.2                     4-CF.sub.3                                                                            4-F       4-CN      Ph      Ph                                        4-CF.sub.3                                                                            4-Cl      4-CO.sub.2 Me                                                                           Ph      Ph                                        ______________________________________                                    

                  TABLE 31                                                        ______________________________________                                         ##STR43##                                                                    R.sub.1                                                                              R.sub.2  R.sub.3  R.sub.8                                                                              R.sub.12                                      ______________________________________                                        4-CF.sub.3                                                                           4-Cl     H        nBu    nBu                                           4-CF.sub.3                                                                           4-F      H        nBu    nBu                                           4-CF.sub.3                                                                           4-OCF.sub.2 H                                                                          H        nBu    nBu                                           4-OCF.sub.3                                                                          4-OCF.sub.2 H                                                                          H        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                           4-Br     H        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                           4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Cl   4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-OCF.sub.3                                                                          4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                           4-F      4-Cl     CH.sub. 2 CH(Me)OCH(Me)CH                            4-OCF.sub.3                                                                          4-F      4-Cl     CH.sub.2 CH(Me)OCH(Me)CH                             4-CF.sub.3                                                                           4-OCF.sub.2 H                                                                          4-Cl     Et     cyclo-C.sub.6 H.sub.11                        4-OCF.sub.3                                                                          4-OCF.sub.2 H                                                                          4-Cl     Et     cyclo-C.sub.6 H.sub.11                        4-CF.sub.3                                                                           4-Cl     4-CN     Et     cyclo-C.sub.6 H.sub.11                        4-CF.sub.3                                                                           4-F      4-CN     iPr    CH.sub.2 CH.sub.2 CO.sub.2 Et                 4-CF.sub.3                                                                           4-Cl     4-CO.sub.2 Me                                                                          CF.sub.3                                                                             2,4-di-ClPh                                   ______________________________________                                    

                  TABLE 32                                                        ______________________________________                                         ##STR44##                                                                    R.sub.1   R.sub.2   R.sub.3   R.sub.10                                        ______________________________________                                        4-CF.sub.3                                                                              4-Cl      H         tBu                                             4-CF.sub.3                                                                              4-F       H         tBu                                             4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H         sec-Bu                                          4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           H         sec-Bu                                          4-CF.sub.3                                                                              4-Br      H         sec-Bu                                          4-CF.sub.3                                                                              4-Cl      4-Cl      Ph                                              4-Cl      4-Cl      4-Cl      Ph                                              4-OCF.sub.3                                                                             4-Cl      4-Cl      Ph                                              4-CF.sub.3                                                                              4-F       4-Cl      4-ClPh                                          4-Cl      4-F       4-Cl      4-ClPh                                          4-OCF.sub.3                                                                             4-F       4-Cl      4-ClPh                                          4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl      4-ClPh                                          4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           4-Cl      2-Me-4-t-BuPh                                   4-CF.sub.3                                                                              4-Cl      4-CN      2-Me-4-t-BuPh                                   4-CF.sub.3                                                                              4-F       4-CN      2-NO.sub.2Ph                                    4-CF.sub.3                                                                              4-Cl      4-CO.sub.2 Me                                                                           2-NO.sub.2Ph                                    ______________________________________                                    

FORMULATION AND USE

The compounds of this invention will generally be used in formulationwith a carrier comprising a liquid or solid diluent or an organicsolvent. Useful formulations of the compounds of this invention areprepared in conventional ways. They include dusts, baits, traps,granules, pellets, solutions, suspensions, emulsions, wettable powders,emulsifiable concentrates, dry flowables and the like. Many of these canbe applied directly. Sprayable formulations can be extended in suitablemedia and used at spray volumes of from about one to several hundredliters per hectare. High strength compositions are primarily used asintermediates for further formulation. The formulations, broadly,contain about 1% to 99% solid or liquid diluent(s). More specifically,they will contain these ingredients in the following approximateproportions:

    ______________________________________                                                  Percent by Weight                                                                Active                                                                        Ingredient                                                                              Diluent(s)                                                                              Surfactant(s)                                ______________________________________                                        Wettable Powders                                                                           25-90      0-74      0-10                                        Oil Suspensions,                                                                            1-50     40-95      0-35                                        Emulsions, Solutions                                                          (including Emulsifi-                                                          able Concentrates)                                                            Dusts         1-25     70-99     0-5                                          Granules, Baits                                                                            0.01-95    5-99      0-15                                        and Pellets                                                                   High Strength                                                                              90-99      0-10     0-2                                          Compositions                                                                  ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers," 2nd Ed., Dorland Books,Caldwell, N.J. The more absorptive diluents are preferred for wettablepowders and the denser ones for dusts. Typical liquid diluents andsolvents are described in Marsden, "Solvents Guide," 2nd Ed.,Interscience, New York, 1950. Solubility under 0.1% is preferred forsuspension concentrates; solution concentrates are preferably stableagainst phase separation at 0° C. "McCurcheon's Detergents andEmulsifiers Annual," Allured Publ. Corp., Ridgewood, N.J., as well asSisely and Wood, "Encyclopedia of Surface Active Agents," Chemical Publ.Co., Inc., New York, 1964, list surfactants and recommended uses. Allformulations can contain minor amounts of additives to reduce foam,caking, corrosion, microbiological growth, etc. Preferably, ingredientsshould be approved by the U.S. Environmental Protection Agency for theuse intended.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet-milling (see, for example, U.S.Pat. No. 3,060,084). Granules and pellets can be made by spraying theactive material upon preformed granular carriers or by agglomerationtechniques. See Browning, "Agglomeration," Chemical Engineering, Dec. 4,1967, pages 147 and following, and "Perry's Chemical Engineer'sHandbook," 4th Ed., McGraw-Hill, New York, 1963, pages 8 to 59 andfollowing.

Many of the compounds of the invention are most efficacious when appliedin the form of an emulsifiable concentrate mixed with a spray oil orspray oil concentrate. Although any oil can be used as a spray oil,spray oils usually have these characteristics: they are not phytotoxicto the crop sprayed, and they have appropriate viscosity. Petroleumbased oils are commonly used for spraying. In some areas, crop oils arepreferred such as the following:

    ______________________________________                                        Common Crop Oils Used as Spray Oils                                           ______________________________________                                        Corn Oil            Linseed Oil                                               Cottonseed Oil      Soybean Oil                                               Coconut Oil         Sunflower Oil                                             Rapeseed Oil        Olive Oil                                                 Peanut Oil          Palm Oil                                                  Safflower Oil       Sesame Oil                                                Mustardseed Oil     Castor Oil                                                ______________________________________                                    

The following oils also meet the criteria for a spray oil: mineral, fishand cod liver oil. Spray oil concentrates comprise a spray oil togetherwith one or more additional ingredients such as emulsifiers and wettingagents. A number of useful spray oil and spray oil concentrates can befound in "A Guide to Agricultural Spray Adjuvants Used in the UnitedStates" by Thomson, Thomson Publications California, 1986.

Examples of useful arthropodicidal formulations of compounds of thepresent invention are as follows.

EXAMPLE A Emulsifiable Concentrate

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                      20%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        blend of oil soluble sulfonates and                                                                       10%                                               polyoxyethylene ethers                                                        isophorone                  70%                                               ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speedsolution. A fine screen filter is included in packaging operation toinsure the substantial absence of extraneous undissolved material in theproduct.

EXAMPLE B Wettable Powder

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                      30%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        sodium alkylnaphthalenesulfonate                                                                           2%                                               sodium ligninsulfonate       2%                                               synthetic amorphous silica   3%                                               kaolinite                   63%                                               ______________________________________                                    

The active ingredient is mixed with the inert materials in a blender.After grinding in a hammermill, the material is reblended and siftedthrough a 5-mesh screen.

EXAMPLE C Dust

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)1-                           methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        Wettable powder of Example B                                                                              10%                                               pyrophyllite (powder)       90%                                               ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blendedand then packaged. The product is suitable for use as a dust.

EXAMPLE D Granule

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)-                                                        10%                                               (1-methylethyl)amino]thio]-N-[4-(trifluoro-                                   methyl)phenyl]amino]carbonyl]-4,5-di-hydro-1H-                                pyrazol-4-yl]benzoate.                                                        attapulgite granules (low volative                                                                        90%                                               matter, 0.71/9/30 mm; U.S.S. No.                                              25-50 sieves)                                                                 ______________________________________                                    

The active ingredient is dissolved in a volatile solvent such as acetoneand sprayed upon dedusted and pre-warmed attapulgite granules in adouble cone blender. The acetone is then driven off by heating. Thegranules are then allowed to cool and are packaged.

EXAMPLE E Emulsifiable Concentrate

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                      10%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        blend of oil soluble sulfonates                                                                            4%                                               and polyoxyethylene ethers                                                    isophorone                  86%                                               ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speedsolution. A fine screen filter is included in packaging operation toinsure the absence of any extraneous undissolved material in theproduct.

EXAMPLE F Wettable Powder

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                      80%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        sodium alkylnaphthalenesulfonate                                                                           2%                                               sodium ligninsulfonate       2%                                               synthetic amorphous silica   3%                                               kaolinite                    3%                                               ______________________________________                                    

The active ingredient is blended with the inert materials in a blender.After grinding in a hammermill, the material is reblended and siftedthrough a U.S.S. 50-mesh screen and packaged.

EXAMPLE G Dust

    ______________________________________                                        wettable powder of Example F                                                                        5%                                                      pyrophyllite (powder)                                                                              95%                                                      ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blendedand then packaged. The product is suitable for use as a dust.

EXAMPLE H Granule

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                      10%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        attapulgite granules (low volative matter,                                                                90%                                               0.71/0.30 mm; U.S.S. No. 25-50 sieves)                                        ______________________________________                                    

The active ingredient is dissolved in a suitable solvent and sprayedonto dedusted attapulgite granules in a double cone blender. Thegranules are warmed to drive off solvent, cooled and packaged.

EXAMPLE I Granule

    ______________________________________                                        wettable powder of Example F                                                                       15%                                                      gypsum               69%                                                      potassium sulfate    16%                                                      ______________________________________                                    

The ingredients are blended in a rotating mixer and water is sprayed onto accomplish granulation. When most of the material has reached thedesired range of 0.1 to 0.42 mm (U.S.S. No. 18 to 40 sieves), thegranules are removed, dried, and screened. Oversize material is crushedto produce additional material in the desired range. These granulescontain 12% active ingredient.

EXAMPLE J Solution

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                      15%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        4-butyrolactone             85%                                               ______________________________________                                    

The ingredients are combined and stirred to produce a solution suitablefor direct, low volume application.

EXAMPLE K Oil Suspension

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                      20%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                        amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                        sodium alkylnaphthalenesulfonate                                                                           4%                                               sodium ligninsulfonate       4%                                               low viscosity methyl cellulose                                                                             3%                                               attapulgite                 69%                                               ______________________________________                                    

The active ingredient is blended with the inert materials in a blender.After grinding in a hammermill to produce particles substantially allbelow 100 microns, the material is reblended and sifted through a U.S.S.50-mesh screen and packaged.

EXAMPLE L Aqueous Suspension

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)-                                                       40%                                                (1-methylethyl)amino]thio]-N-[4-(trifluoromethyl)-                            phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazol-4-                              yl]benzoate.                                                                  polyacrylic acid thickener                                                                               0.3%                                               dodecyclophenol polyethylene glycol                                                                      0.5%                                               ether                                                                         disodium phosphate         1.0%                                               monosodium phosphate       0.5%                                               polyvinyl alcohol          1.0%                                               water                     56.7%                                               ______________________________________                                    

The ingredients are blended and ground together in a sand mill toproduce particles substantially all under 5 microns in size.

EXAMPLE M Oil Suspension

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[ethoxycarbonyl)-                                                       35.0%                                               (1-methylethyl)amino]thio]-N-[4-(trifluoromethyl)-                            phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazol-4-                              yl]benzoate.                                                                  blend of polyalcohol carboxylic                                                                          6.0%                                               esters and oil soluble petroleum                                              sulfonates                                                                    xylene range solvent      59.0%                                               ______________________________________                                    

The ingredients are combined and ground together in a sand mill toproduce particles substantially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE N Emulsifiable Concentrate

    ______________________________________                                        methyl 7-chloro-2-[[N-[[[(hexyloxy)carbonyl]-methyl-                                                      5%                                                amino]-thio]-N-[4-(trifluoromethyl)-phenyl]amino]-                            carbonyl]-3,3a,4,5-tetrahydro-2H-benz[g]indazole-3a-                          carboxylate.                                                                  blend of oil soluble sulfonates                                                                           4%                                                and polyoxyethylene ethers                                                    xylene                     91%                                                ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speedsolution. A fine screen filter is included in packaging operation toinsure the absence of any extraneous undissolved material in theproduct.

EXAMPLE O Wettable Powder

    ______________________________________                                        methyl 7-chloro-2-[[N-[[[(hexyloxy)carbonyl]-methyl-                                                     30%                                                amino]-thio]-N-[4-(trifluoromethyl)-phenyl]amino]-                            carbonyl]-3,3a,4,5-tetrahydro-2H-benz[g]indazole-3a-                          carboxylate.                                                                  sodium alkylnaphthalenesulfonate                                                                          2%                                                sodium ligninsulfonate      2%                                                synthetic amorphous silica  3%                                                kaolinite                  63%                                                ______________________________________                                    

The active ingredient, warmed to reduce viscosity, is sprayed onto theinert materials in a blender. After grinding in a hammer-mill, thematerial is reblended and sifted through a 50 mesh screen.

EXAMPLE P Solution

    ______________________________________                                        methyl 7-chloro-2-[[N-[[[(hexyloxy)carbonyl]-methyl-                                                     10%                                                amino]-thio]-N-[4-(trifluoromethyl)-phenyl]amino]-                            carbonyl]- 3,3a,4,5-tetrahydro-2H-benz[g]indazole-3a-                         carboxylate.                                                                  isophorone                 90%                                                ______________________________________                                    

The ingredients are combined and stirred to produce a solution suitablefor direct, low volume application.

EXAMPLE O Bait Granules

    ______________________________________                                        methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)-                                                       3.0%                                               (1-methylethyl)amino]thio]-N-[4-(trifluoromethyl)-                            phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazol-4-                              yl]benzoate.                                                                  blend of polyethoxylated nonyl-                                                                          9.0%                                               phenols an sodium dodecylbenzene                                              benzene sulfonates                                                            ground up corn cobs       88.0%                                               ______________________________________                                    

The active ingredient and surfactant blend are dissolved in a suitablesolvent such as acetone and sprayed onto the ground corn cobs. Thegranules are then dried and packaged. Compounds of Formula I, II and/orIII can also be mixed with one or more other insecticides, fungicides,nematocides, bactericides, acaricides, or other biologically activecompounds to form a multi-component pesticide giving an even broaderspectrum of effective pesticide protection. Examples of otheragricultural protectants with which compounds of the present inventioncan be mixed or formulated are as follows.

Insecticides

3-hydroxy-N-methylcrotonamide(dimethylphosphate)ester (monocrotophos)

methylcarbamic acid, ester with 2,3-dihydro-2,2-dimethyl-7-benzofuranol(carbofuran)

O-[2,4,5-trichloro-α-(chloromethyl)benzyl]ophosphoric acid,O',O'-dimethyl ester (tetrachlorvinphos)

2-mercaptosuccinic acid, diethyl ester, S-ester with thionophosphoricacid, dimethyl ester (malathion)

phosphorothioic acid, O,O-dimethyl, O-p-nitrophenyl ester (methylparathion)

methylcarbamic acid, ester with α-naphthol (carbaryl)

methyl O-(methylcarbamoyl)thiolacetohydroxamate (methomyl)

N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlordimeform)

O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidylphosphorothioate(diazinon)

octachlorocamphene (toxaphene)

O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN)(S)-a-cyano-m-phenoxybenzyl(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate(deltamethrin) Methyl

N',N'-dimethyl-N-[(methylcarbamoyl)oxy]-1-thiooxamimidate (oxamyl)

cyano(3-phenoxyphenyl)-methyl-4-chloro-a-(1-methylethyl)benzeneacetate(fenvalerate)

(3-phenoxyphenyl)methyl(±)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate(permethrin)

a-cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (cypermethrin)O-ethyl-S-(p-chlorophenyl)ethylphosphonodithioate (profenofos)

phosphorothiolothionic acid

O-ethyl-O-[4-methylthio)-phenyl]-S-n-propyl ester (sulprofos).

Additional insecticides are listed hereafter by their common names:triflumuron, diflubenzureon, methoprene, buprofezin, thiodicarb,acephate, azinphosmethyl, chlorpyrifos, dimethoate, fonophos,isofenphos, methidathio, methamidiphos, monocrotphos, phosmet,phosphamidon, phosalone, pirimicarb, phorate, profenofos, terbufos,trichlorfon, methoxychlor, bifenthrin, biphenate, cyfluthrin,fenpropathrin, fluvalinate, flucythrinate, tralomethrin, metaldehyde androtenone.

Fungicides

methyl 2-benzimidazolecarbamate (carbedazim)

tetramethylthiuram disulfide (thiuram)

n-dodecylguanidine acetate (dodine)

manganese ethylenebisdithiocarbamate (maneb)

1,4-dichloro-2,5-dimethoxybenzene (chloroneb)

methyl 1-(butylcarbamoly)-2-benzimidazolecarbamate (benomyl)

1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole(propiconazole)

2-cyano-N-ethylcarbamoy-2-methoxyiminoacetamide (cymoxanil)

1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone(triadimefon)

N-(trichloromethylthio)tetrahydrophthalimide (captan)

N-(trichloromethylthio)phthalimide (folpet)

1-[[[bis(4-fluorophenyl)][methyl]silyl]methyl]-1H-1,2,4-triazole.

Nematocides

S-methyl 1-(dimethylcarbamoyl)-N-(methylcarbamoyloxy)thioformimidate

S-methyl

1-carbamoyl-N-(methylcarbamoyloxy)thioformimidate

N-isopropylphosphoramidic acid, O-ethyl

O'-[4-(methylthio)-m-tolyl]diester (fenamiphos)

Bactericides

tribasic copper sulfate

streptomycin sulfate

Acaricides

senecioic acid, ester with 2-sec-butyl-4,6-dinitrophenol (binapacryl)

6-methyl-1,3-cithiolo[4,5-β]quinoxalin-2-one (oxythioquinox)

ethyl 4,4'-dichlorobenzilate (chlorobenzilate)1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol (dicofol)

bis(pentachloro-2,4-cyclopentadien-1-yl) (dienochlor) tricyclohexyltinhydroxide (cyhexatin)

trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxothiazolidine-3-carboxamide(hexythiazox)

amitraz

propargite

fenbutatin-oxide

Biological

Bacillus thuringiensis

Avermectin B.

Utility

The compounds of the present invention exhibit activity against a widespectrum of foliar and soil-inhabiting, livestock, household and publichealth arthropods. Those skilled in the art will recognize that not allcompounds will be equally effective against all arthropods but thecompounds of this invention display activity against economicallyimportant pest species, such as grasshoppers and cockroaches includingGerman or American roaches; thrips; hemipterans: plant bugs (Miridae)such as tarnished plant bugs, lace bugs (Tingidae), seed bugs(Lygaeidae) such as cinch bugs, stick bugs (Pentatomidae), leaf-footedbugs (Coreidae) such as squash bug, and red bugs and stainers(Pyrrocoridae) such as cotton stainer; also homopterans such aswhiteflies, aphids such as the green peach aphid, greenbug and cottonasphid, leafhoppers, spittlebugs and planthoppers such as asterleafhopper, potato leafhopper and rice planthoppers, psyllids such aspear psylla, scales (coccids and diaspidids) and mealybugs; coleopteransincluding weevils such as boll weevil and rice water weevil, grainborers, chrysomellid beetles such as Colorado potato beetle, fleabeetles and other leaf beetles, coccinellid beetles such as Mexican beanbeetle.

Activity is also shown against soil insects such as southern cornrootworm and wireworm; lepidopterous larvae including noctuids such asfall armyworm, beet armyworm, other Spodoptera spp., Heliothis spp. suchas virescens, Heliothis zea, cabbage looper, green cloverworm,velvetbean caterpillar, cotton leafworm, black cut- worm, and othernoctuid cutworms and including pyralids such as European corn borer,navel orange- worm, and stalk/stem borers and including tortiricids likecodling moth and grape berry moth as well as other lepidopterous larvaesuch as pink bollworm and diamodback moth; and dipterans such asleafminer, soil maggots, midges, and tephritid fruit flies; house fly,Musca domestica; stable fly, Stomoxys calcitrans; black blow fly,Phormia regina; face, fly, Musca autumnalis; black fly, Simulummeridionale; yellow fever mosquito, Aedes egypti; German cockroach,Blattella germanica; carpenter ants, Camponotus pennsylvanicus andeastern subterranean termite, Reticulitermes flavipes. The pest controlafforded by the compounds of the present invention is not limited,however, to these species.

The specific species, for which control is exemplified below, are: fallarmyworm, Spodoptera frugiperda; tobacco budworm, Heliothis virescens;southern corn rootworm, Diabrotica undecimpunctata howardi; asterleafhopper, Macrosteles fascifrons. The pest control afforded by thecompounds of the present invention is not limited, to these species.

Application

Arthropods are controlled in agricultural crops and animals and humansare protected by applying one or more of the compounds of thisinvention, in an effective amount, to the locus of infestation, to thearea to be protected, directly to the pests to be controlled, or totheir environment. A preferred method of application is by spraying withspray equipment that distributes the compound on the foliage, in thesoil, or to the plant part that is infested or needs to be protected.Alternatively, granular formulations of these compounds can be appliedto soil or foliage or, optionally, incorporated into the soil. Eitheraerial or ground application can be used. Because of the diversity ofbehavior patterns and habitats of the animal and human health species,many different methods of application are employed. These include directand residual sprays, baits, ear tags, soil treatment and many others.

The pyrazoline compound(s) of this invention can be applied directly,but most often application will be of a formulation comprising one ormore compounds of this invention, in an agriculturally suitable carrieror diluent. A most preferred method of application involves spraying awater dispersion or refined oil solution of the compounds. Thecompound(s) can also be incorporated into baits which are consumed or indevices such as traps and the like that entice the arthropod to ingestor otherwise contact the toxicant compound(s).

the rate of application of Formula I, II or III compounds required foreffective control will depend on such factors as the species ofarthropod to be controlled, the pest's life stage, its size, itslocation, the host crop, time of year of application, ambient moisture,temperature conditions, and the like. In general, application rates of0.01 to 2 kg of active ingredient per hectare are sufficient to provideseffective control in large scale field operations under normalcircumstances, but as little as 0.001 kg/hectare may be sufficient or asmuch as 8 kg/hectare may be required for agricultural use, or 0.1 mg/ft²to 20 mg/ft² for home use, depending upon the factors listed above.

The following Examples demonstrate the control efficacy of compounds ofFormulae I, II and III on specific arthropod pests wherein Compounds 1through 55 are depicted in the Examples and Tables A, B and C andsummarized in Table D, respectively.

                  TABLE D                                                         ______________________________________                                        CMPD   R.sub.1                                                                              R.sub.2                                                                              R.sub.3                                                  ______________________________________                                         ##STR45##                                                                                              X                                                   1      CF.sub.3                                                                             H           N(CH[CH.sub.3 ].sub.2)CO.sub.2 Et                   2      CF.sub.3                                                                             H           CO.sub.2  .sub.-s-Bu                                3      CF.sub.3                                                                             H           N(n-Bu).sub.2                                       4      CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2  -n-hexyl                       5      CF.sub.3                                                                             H           N(CH.sub.3)CO.sub.2  -n-Bu                          6      CF.sub.3                                                                             H           N(CH.sub.3)CO.sub.2 Et                              7      CF.sub.3                                                                             4-F         N(CH.sub.3)CO.sub.2  -n-Bu                          8      CF.sub.3                                                                             H           N(CH.sub.3)CO.sub.2 cyclohexyl                      9      CF.sub.3                                                                             H           N(CH.sub.3)CO.sub.2  -n-octyl                       10     CF.sub.3                                                                             H           N(CH.sub.3)CO.sub.2  -n-decyl                       11     CF.sub.3                                                                             4-F         N[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                   12     CF.sub.3                                                                             H           N(CH.sub.3)CO.sub.2  -n-dodecyl                     13     CF.sub.3                                                                             H           N(CH.sub.3)CO.sub.2  -n-hexyl                       14     CF.sub.3                                                                             5-Cl        CO.sub.2  .sub.-s-Bu                                15     CF.sub.3                                                                             5-Cl        N[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                   16     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 Et                              17     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2  -n-octyl                       18     CF.sub.3                                                                             4-F         CO.sub.2  .sub.-s-Bu                                19     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2  -n-Bu                          20     CF.sub.3                                                                             5-Cl        N[CH.sub.3 (CH.sub.3).sub.2 ]CO.sub.2  -n-Bu        21     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2  -n-dodecyl                     22     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 cyclohexyl                      23     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 (CH.sub.2).sub.2 OBu            24     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 C.sub.14 H.sub.29               25     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 C.sub.16 H.sub.33               26     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 C.sub.18 H.sub.37               27     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 C.sub.22 H.sub.45               28     CF.sub.3                                                                             5-Cl        N(CH.sub.3)CO.sub.2 (CH.sub.2).sub.2 O(CH.sub.2)                              .sub.2 OBu                                           ##STR46##                                                                                              Y                                                   29     CF.sub.3                                                                             4-Cl   4-F  N[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                   31     CF.sub.3                                                                             4-Cl   4-F  N[CH(CH.sub.3).sub.2 ]CO.sub.2 Bu                   32     CF.sub.3                                                                             4-Cl   4-F  N[CH(CH.sub.3)CH.sub.2 CH.sub.3 ]CO.sub.2 Et        33     CF.sub.3                                                                             4-Cl   4-F  CO.sub.2  .sub.-s-Bu                                34     CF.sub.3                                                                             4-Cl   4-F  N(CH.sub.3)CO.sub.2 cyclohexyl                       ##STR47##                                                                                              Q                                                   30     CF.sub.3                                                                             4-Cl   4-Cl SN[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                  35     CF.sub.3                                                                             4-Cl   4-Cl SN(CH.sub.3)CO.sub.2  .sub.-s-Bu                    36     CF.sub.3                                                                             4-Cl   4-Cl SCO.sub.2  .sub.-s-Bu                               37     Cl     4-Cl   4-Cl SCO.sub.2  .sub.-s-Bu                               38     CF.sub.3                                                                             4-Cl   4-Cl CO.sub.2 CH.sub.3                                   39     CF.sub.3                                                                             4-Cl   4-F  COCH.sub.3                                          40     CF.sub.3                                                                             4-Cl   4-Cl SN[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                  41     CF.sub.3                                                                             4-Cl   4-Cl COCH.sub.3                                          42     4-Cl   4-Cl   4-F  COCH.sub.3                                          43     Br     4-Cl   4-F  COCH.sub.3                                          44     CF.sub.3                                                                             4-Cl   4-F  CO.sub.2 CH.sub.3                                   45     CF.sub.3                                                                             4-Cl   4-F  COPh                                                46     CF.sub.3                                                                             4-Cl   4-Cl COCH.sub.2 CH.sub.3                                 47     CF.sub.3                                                                             4-Cl   4-Cl COCOCH.sub.2 CH.sub.3                               48     CF.sub.3                                                                             4-Cl   4-Cl CO -n-Bu                                            49     Cl     4-Cl   4-Cl COCH.sub.3                                          50     Cl     4-Cl   4-Cl COCH.sub.2 CH.sub.3                                 51     Cl     4-Cl   4-Cl CO.sub.2 CH.sub.3                                   52     CF.sub.3                                                                             4-Cl   4-Cl CO-4-ClPh                                           53     CF.sub.3                                                                             4-Cl   4-Cl CO .sub.-t-Bu                                       54     CF.sub.3                                                                             4-Cl   4-Cl CO.sub.2 Ph                                         ______________________________________                                    

EXAMPLE 56 Fall Armyworm

Test units, each consisting of an 8-ounce plastic cup containing a layerof wheat germ diet, approx. 0.5 cm thick, were prepared. Tenthird-instar larvae of fall armyworm (Spodoptera frugiperda) were placedinto each cup. Solutions of each of the test compounds(acetone/distilled water 75/25 solvent) were sprayed onto the cups, asingle solution per set of three cups. Spraying was accomplished bypassing the cups, on a conveyor belt, directly beneath a flat fanhydraulic nozzle which discharged the spray at a rate of 0.5 pounds ofactive ingredient per acre (about 0.55 kg/ha) at 30 p.s.i. The cups werethen covered and held at 27° C. and 50% relative humidity for 72 hours,after which time mortality readings were taken.

Of the compounds tested on fall armyworm, the following resulted ingreater than or equal to 80% mortality: 1, 2, 4, 5, 6, 6, 9, 10, 11, 12,13, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33,35, 36, 38, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, and 54.

EXAMPLE 57 Tobacco Budworm

The test procedure of Example 56 was repeated for efficacy againstthird-instar larvae of the tobacco budworm (Heliothis virescens) exceptthat mortality was assessed at 48 hours. Of the compounds tested ontobacco budworm, the following resulted in greater than or equal to 80%mortality: 2, 4, 7, 11, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28,29, 30, 31, 32, 33, 35, 36, 38, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51,52, 53 and 54.

EXAMPLE 58 European Corn Borer

Test units, each consisting of an 8-ounce plastic cup containing aone-inch square of wheat germ/soyflour diet, were prepared. Fivethird-instar larvae of the European corn borer (Ostrinia nubilalis) wereplaced into each cup. Sets of three test units were sprayed as describedin Example 56 with individual solutions of the test compounds. The cupswere then covered and held at 27° C. and 50% relative humidity for 48hours, after which time mortality readings were taken. Of the compoundstested on European corn borer, the following resulted in greater than orequal to 80% mortality: no testing.

EXAMPLE 59 Southern Corn Rootworm

Test units, each consisting of an 8-ounce plastic containing 1 sproutedcorn (Zea mays) see, were prepared. Sets of three test units weresprayed as described in Example 56 with individual solutions of the testcompounds. After the spray on the cups had dried, five third-instarlarvae of the southern corn rootworm (Diabrotica undecimpunctatahowardi) were placed into each cup. A moistened dental wick was insertedinto each cup to prevent drying and the cups were then covered. The cupswere then held at 27° C. and 50% relative humidity for 48 hours, afterwhich time mortality readings were taken.

Of the compounds tested on southern corn rootworm, the followingresulted in greater than or equal to 80% mortality: 1, 2, 3, 4, 5, 6, 9,10, 11, 13, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31,32, 35, 36, 38, 41, 42, 44, 45, 47, 48, 49 and 51.

EXAMPLE 60 Aster Leafhopper

Test units were prepared from a series of 12-ounce cups, each containingoat (Avena sativa) seedlings in a 1-inch layer of sterilized soil. Setsof three test units were sprayed as described in Example 56 withindividual solutions of the below-listed compounds. After the oats haddried from the spraying, between 10 and 15 adult aster leafhoppers(Mascrosteles fascifroms) were aspirated into each of the cups. The cupswere held at 27° C. and 50% relative humidity for 48 hours, after whichtime mortality readings were taken.

Of the compounds tested on aster leafhopper, the following resulted ingreater than or equal to 80% mortality: 1, 2, 3, 4, 5, 6, 8, 9, 10, 11,12, 13, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28, 30, 31, 35, 36, 38,41, 42, 43, 44, 45, 47, 49, 50 and 51.

EXAMPLE 61 Boll Weevil

Five adult boll weevils (Anthonomus grandis) were placed into each of aseries of 9-ounce cups. The test procedure employed was then otherwisethe same as in Example 56 with three cups per treatment. Mortalityreadings were taken 48 hours after treatment.

Of the compounds tested on boll weevil, the following resulted ingreater than or equal to 80% mortality: 16, 21, 22, 23, 24, 25, 26, 27,28, 30, 35, 36, 38, 41, 42, 43, 44, 46, 48, 49, 50, 51, 52 and 54.

What is claimed is:
 1. A compound of the formula: ##STR48## wherein A isa 1, 2 or 3-atom bridge comprising 0 to 3 carbon atoms, 0 to 1 oxygenatoms, NR₆, or S(O)q, wherein each carbon individually can besubstituted with 1 to 2 substituents selected from 1 to 2 halogen, C₁ toC₆ alkyl, C₂ to C₄ alkoxycarbonyl or phenyl optionally substituted with1 to 3 substituents independently selected from W and one of the carbonatoms can be combined into the group C(O) or C(S);B is H, C₁ to C₆alkyl, C₄ to C₇ cycloalkyl alkyl, C₃ to C₆ cycloalkyl optionallysubstituted with 1 to 2 halogens or 1 to 2 CH₃ ; C₁ to C₆ haloalkyl, C₂to C₆ alkenyl, C₂ to C₆ haloalkeny, C₂ to C₆ alkynyl, OR₇, C₂ to C₆alkoxyalkyl, C₂ to C₆ cyanoalkyl, C₃ to C₈ alkoxycarbonylalkyl, CO₂ R₄,C(O)R₄, C(O)NR₄ R₅, C(S)NR₄ R₅, C(S)R₄, C(S)SR₄, phenyl, phenylsubstituted by (R₁₄)p, benzyl, or benzyl substituted with 1 to 3substituents independently selected from W; J is H, C₁ to C₄ alkyl orphenyl optionally substituted with W; K is H or CH₃ ; q is 0, 1 or 2;R₁, R₂, and R₁₄ are independently selected from R₄, halogen, CN, N₃,SCN, NO₂, OR₄, SR₄, S(O)R₄, S(O)₂ R₄, OC(O)R₄, OS(O)₂ R₄, CO₂ R₄,C(O)R₄, C(O)NR₄ R₅, S(O)₂ NR₄ R₅, NR₄ R₅, NR₅ C(O)R₄, OC(O)NHR₄, NR₅C(O)NHR₄ and NR₅ S(O)₂ R₄ ; or when m, n or p is 2, R₁, R₂, or R₁₄ canindependently be taken together as OCH₂ O, OCH₂ CH₂ O or CH₂ CH₂ O, toform a 5 or 6-membered ring, each of which can be independentlysubstituted with 1 to 4 halogen atoms or 1 to 2 methyl groups; R₄ isselected from H, C₁ to C₆ alkyl, C₃ to C₆ cycloalkyl, C₃ to C₈alkoxycarbonylalkyl, C₃ to C₆ alkenyl, C₃ to C₆ alkynyl, C₁ to C₆haloalkyl, C₃ to C₆ haloalkenyl, C₁ to C₆ alkyl substituted with CN, CO₂CH₃, CO₂ CH₂ CH₃, OCH₃, OCH₂ CH₃, SCH₃, SCH₂ CH₃ or NO₂, or R₄ is phenylor benzyl, either optionally substituted with W; or R₄ and R₅ can betaken together as (CH₂)₄, (CH₂)₅ or CH₂ CH₂ OCH₂ CH₂ ; R₅ is selectedfrom H, C₁ to C₄ alkyl, C₃ to C₄ alkenyl, C₃ to C₄ alkynyl or C₁ to C₄haloalkyl; m, n and p are independently 1 to 3; W is halogen, CN, NO₂,C₁ to C₂ alkyl, C₁ to C₂ haloalkyl, C₁ to C₂ alkoxy, C₁ to C₂haloalkoxy, C₁ to C₂ alkylthio, C₁ to C₂ haloalkylthio, C₁ to C₂alkylsulfonyl or C₁ to C₂ haloalkylsulfonyl; R₆ is H, C₁ to C₄ alkyl, C₁to C₄ haloalkyl, C₂ to C₄ alkenyl, C₂ to C₄ haloalkenyl, phenyloptionally substituted with W or benzyl optionally substituted with W;R₇ is H, C₁ to C₄ alkyl, C₂ to C₄ alkenyl, C₂ to C₄ alkynyl, C₂ to C₄alkylcarbonyl, C₂ to C₄ alkoxycarbonyl or C₁ -C₄ alkylsulfonyl; Z is SX;X is ##STR49## R₈ and R₁₂ are independently C₁ to C₆ alkyl, C₁ to C₆haloalkyl, C₃ to C₆ cycloalkyl, C₄ to C₇ cycloalkylalkyl, phenyloptionally substituted by 1 to 2 substituents selected from W, benzyloptionally substituted by 1 to 2 substituents independently selectedfrom W, phenethyl optionally substituted by 1 to 2 substituentsindependently selected from W, C₂ to C₆ cyanoalkyl, C₂ to C₆alkoxyalkyl, C₃ to C₈ alkoxycarbonylalkyl, C₄ to C₈dialkylaminocarbonylalkyl; or R₈ and R₁₂ can be taken together as(CH₂)₄, (CH₂)₅ or (CH₂)₂ O(CH₂)₂, R₉ is F, C₁ to C₂₂ alkyl, C₃ to C₆cycloalkyl, C₃ to C₆ cycloalkoxy, C₂ to C₈ dialkylamino, C₁ to C₆haloalkyl, phenyl or phenoxy either optionally substituted by 1 to 2substituents independently selected from W; C₁ to C₂₂ alkoxy, C₁ to C₄alkoxy substituted by cyano, nitro, C₂ to C₄ alkoxy, C₄ to C₈alkoxyalkoxy, C₁ to C₂ alkylthio, C₂ to C₃ alkoxycarbonyl, C₃ to C₅dialkylaminocarbonyl, phenyl or 1 to 6 halogens; or R₉ is morpholino,piperidino or pyrrolidino, 1-naphthoxy,2,2-dimethyl-2,3-dihydrobenzofuranoxy-7 or ON═C(CH₃)SCH₃ ; R₁₀ and R₁₁are independently C₁ to C₄ alkyl, C₂ to C₄ haloalkyl or phenyloptionally substituted by 1 to 2 substituents independently selectedfrom W; or R₁₀ and R₁₁ can be taken together as (CH₂)₂, (CH₂)₃ or CH₂C(CH₃)₂ CH₂ ; Y' is S or O; and a is 0 to
 2. 2. A compound according toclaim 1 wherein:R₁, R₂, and R₁₄ are independently R₄, CO₂ R₄, halogen,CN, NO₂, OR₄, SR₄, S(O)R₄, S(O)₂ R₄ or NR₄ R₅, or when m, n or p is 2;R₁, R₂, or R₁₄ can be taken together as OCH₂ O, OCH₂ CH₂ O or CH₂ CH₂ O,each of which can be substituted with 1 to 4 halogen atoms or 1 to 2methyl groups; R₄ is C₁ to C₂ alkyl, C₃ to C₄ alkenyl, C₁ to C₂haloalkyl, C₃ to C₄ haloalkenyl or phenyl optionally substituted withhalogen; R₅ is H or C₁ to C₂ alkyl; X is X₁, X₂, X₃, or X₄ ; R₈ and R₁₂are independently C₁ to C₆ alkyl, C₁ to C₆ haloalkyl, C₅ to C₆cycloalkyl, C₃ to C₈ alkoxycarbonylalkyl, phenyl, benzyl or phenethyl,each optionally independently substituted with W; or R₈ and R₁₂ can betaken together as (CH₂)₄, (CH₂)₅ or (CH₂)₂ O(CH₂)₂ ; R₁₀ and R₁₁ areindependently C₁ to C₃ alkyl or phenyl; a is 2; Formula III is ##STR50##X' is O or S; t is 0, 1 or 2; V is O, S(O)_(q), or NR₆ ; Z' is O or NR₆; R₁₃ is H, halogen, C₁ to C₆ alkyl, C₂ to C₄ alkoxycarbonyl, phenyl orphenyl substituted by 1 to 3 substituents independently selected from W;and g is 0, 1 or
 2. 3. A compound according to claim 2 wherein:R₁ ishalogen, CN, NO₂, OCF₂ H, OCF₃, OCH₂ CF₃, OCF₂ CF₂ H, CF₃ or when m is 2then R₁ may be taken together as CH₂ C(CH₃)₂ O or CF₂ CF₂ O to form a 5membered ring; R₂ is H, halogen, CN, NO₂, OCH₃, OCF₂ H, OCH₂ CF₃, OCF₃,SCH₃, SCF₂ H, SCF₃, CF₃, OCF₂ CF₂ H or phenoxy; R₁₄ is R₂ or CO₂ R₄ ; Xis X₁, X₂ or X₃ ; R₈ is C₁ to C₄ alkyl, CF₃, cyclohexyl, phenyloptionally substituted with W or benzyl optionally substituted by W; R₉is F, C₁ to C₂₂ alkyl, C₁ to C₆ haloalkyl, phenyl or phenoxy optionallysubstituted by W; C₁ to C₂₂ alkoxy, dimethylamino or C₁ to C₄ alkoxysubstituted with NO₂, C₂ to C₄ alkoxy or 1 to 6 halogens; m, n or p areindependently 1 to 2 and one substituent is in the 4-position and B isH, C₁ -C₄ alkyl, CO₂ R₄, --C(O)R₄ or phenyl optionally substituted by(R₁₄)p.
 4. A compound according to claim 3 wherein:X is X₁ ; R₈ is C₁ toC₄ alkyl; R₉ is C₁ to C₂₂ alkoxy; Formula III is III-1 or III-2; V is Oor CH₂ ; t is 1; and R₁₃ is H.
 5. A compound according to claim 3wherein:X is X₂ ; R₈ is C₁ to C₄ alkyl or phenyl optionally substitutedwith CH₃ or Cl; and R₉ is C₁ to C₆ alkyl, C₁ to C₆ haloalkyl,dimethylamino or phenyl optionally substituted with CH₃ or Cl.
 6. Acompound according to claim 3:methyl7-chloro-3,3a,4,5-tetrahydro-2-[[N-[[N-methyl-N-[octadecyloxy)carbonyl]amino]thio]-N-[4-(trifluoromethyl)-phenyl]amino]carbonyl]-2H-benzindazole-3a-carboxylate.7. An arthropodicidal composition comprising an arthropodicidallyeffective amount of a compound according to any one of claims 1 to 5 or6 and a carrier therefor.
 8. A method for controlling arthropodscomprising applying to them or their environment an arthropodicallyeffective amount of a compound according to any one of claims 1 to 5 or6.